Synovial Membrane
Response of the rheumatoid synovial membrane to exogenous immunization
... The secondary immune response to tetanus toxoid in 14 patients with rheumatoid arthritis (RA) has been studied in suspension cultures of peripheral blood lymphocytes (PBL) and synovial membrane obtained at ...
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Matrix Metalloproteinase dependent turnover of cartilage, synovial membrane, and connective tissue is elevated in rats with collagen induced arthritis
... In this study we used newly developed biochemical mar- kers based on neo-epitopes of type I, II, and III collagen degradation (C1M [20], C2M [21], C3M [22]) and forma- tion (P1NP [23], P2NP(unpublished), ...
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Synovial membrane protein expression differs between juvenile idiopathic arthritis subtypes in early disease
... suggesting a process of serial post translational modifica- tions. ITA2B contains five N-linked glycosylation points [24]. Furthermore, intense ITA2B immunostaining was observed around blood vessels in the oligoarticular ...
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CD4+CD25+/highCD127low/ regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints—analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood
... the synovial membrane (SM) as the main site of mononuclear cell ...to synovial inflammation ...the synovial fluid (SF) of RA joints ...analysed synovial biopsies and suggested a much ...
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Synovial membrane mesenchymal stem cells: past life, current situation, and application in bone and joint diseases
... into synovial joint cavity through synovial ves- sels, however which is only found in animal ...and synovial cells ex- press lamellar bodies, so it is supported that SM-MSCs may come from ...
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Tumour necrosis factor activates the mitogen activated protein kinases p38α and ERK in the synovial membrane in vivo
... the synovial membrane, indicating that the intracellular effects of TNF can be ...the synovial membrane, such as the MAPKs, and thereby reduces inflammatory response in the tissue exposed to ...
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<p>Increase in Tryptase and Its Role in the Synovial Membrane of Overweight and Obese Patients with Osteoarthritis of the Knee</p>
... positive synovial macrophages in cultured SM cells derived from RA ...in synovial macrophages and fi ...to synovial in fl ammation through activation of synovial fi broblasts and macrophages in ...
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Original Article Immunohistochemical detection of cartilage intermediate layer protein 1 in the synovial membrane of patients with knee complaints
... the synovial membranes. Synovial membrane samples were collected from 30 patients, who formed a subset of an extensive osteoarthritis (OA) study and who had undergone knee arthroscopy due to knee ...
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Identification of intra group, inter individual, and gene specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane
... Introduction Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease characterized by overexpression of pro-inflammatory/pro-destructive genes and other activating genes (for example, ...
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Suppression of the inflammatory response by disease inducible interleukin 10 gene therapy in a three dimensional micromass model of the human synovial membrane
... The synovial micromass membrane contains FLS and MLS In previous studies that used the synovial micromass model, primary FLS were used that had been cultured for multiple ...of synovial cell ...
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Binding immunoglobulin protein resolves rheumatoid synovitis: a xenogeneic study using rheumatoid arthritis synovial membrane transplants in SCID mice
... Biologic therapies have been successfully used in the therapy of RA over the past decade but a significant number of patients fail to respond to their treatment [3]. BiP, however, has a different mechanism of action from ...
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Effects over time of two platelet gel supernatants on growth factor, cytokine and hyaluronan concentrations in normal synovial membrane explants challenged with lipopolysaccharide
... in synovial fluid to determine which of the two concentrations of the PRG supernatants could re- flect a near or similar apparently healthy molecular syn- ovial fluid environment in the culture media of the SME ...
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Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis
... Using the same number of exosomes, iMSC-Exos exerted a superior therapeutic effect compared with SMMSC-Exos in the mouse OA model. Cartilage treated by SMMSC-Exos showed moderate surface irregularity, superficial ...
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The vif gene is essential for efficient replication of caprine arthritis encephalitis virus in goat synovial membrane cells and affects the late steps of the virus replication cycle.
... Complex retrovirus genomes contain a variable number of accessory genes, among which is the vif gene. We investigated in vitro the role of the vif gene of caprine arthritis encephalitis virus (CAEV) by studying the ...
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Original Article Elevated chemerin levels in synovial fluid and synovial membrane from patients with knee osteoarthritis
... the synovial fluid and synovial membrane levels of chemerin were positively correlated with the Ayral score of ...the synovial membrane level of chemerin and the Ayral ...the ...
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T Cells and T-Cell Cytokine Transcripts in the Synovial Membrane in Patients with Osteoarthritis
... Osteoarthritis (OA), although a heterogeneous disease, is generally believed by rheumatologists to be primarily a disease of biomechanical alteration (18). However, apart from the relatively rare type of erosive ...
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The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy
... ovial membrane) and classified it as follows: grade 1, no synovitis; grade 2, focal synovitis at the labral tear; grade 3, diffuse synovitis in the area surrounding the ...the synovial membrane from ...
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Original Article IL-17 expression in synovial fluid and synovial membrane in patients with knee osteoarthritis
... Tissue specimens of synovial membrane were collected during arthroscopic surgery. The specimens were washed twice with normal saline within one hour of surgery and then cut into approximately 0.5 cm × 0.5 ...
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Decreased Expression of the CD3ζ Chain in T Cells Infiltrating the Synovial Membrane of Patients with Osteoarthritis
... Osteoarthritis (OA) is a heterogeneous disease (3). Rheu- matologists generally consider OA to be a noninflammatory disease (3), although patients with OA often exhibit inflamma- tory infiltrates in the synovial ...
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Synovial membrane immunohistology in early untreated rheumatoid arthritis reveals high expression of catabolic bone markers that is modulated by methotrexate
... Methods: In this study, 15 patients with newly diagnosed RA (median symptom duration 7 months) were started on methotrexate (MTX) 20 mg weekly. Synovial biopsies were obtained by needle arthroscopy at baseline and ...
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