Systemic administration
Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies
... Another type of drug recently developed for osteopor- osis treatment is strontium (Sr) ranelate (SRAN) [14–16]. This drug is a salt consisting of two atoms of stable stron- tium (Sr 2+ ) and an organic acid (Ranelic ...
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Effect of nonsurgical periodontal treatment in conjunction with either systemic administration of amoxicillin and metronidazole or additional photodynamic therapy on the concentration of matrix metalloproteinases 8 and 9 in gingival crevicular fluid in patients with aggressive periodontitis
... The systemic administration of amoxicillin and metronidazole in conjunction with mechanical debridement (SRP) has been shown to be a successful method to reduce or eliminate ...of systemic ...
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Dexamethasone uptake in the murine organ of Corti with transtympanic versus systemic administration
... After systemic and transtympanic injection, a decreasing basal-apical gradient of steroid uptake was present within hair cells which has not been previously characterized (Figure ...after systemic ...
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Shifts in the balance of brain tryptophan metabolism due to age and systemic administration of lipopolysaccharide
... levels. Systemic LPS ad- ministration is known to increase both brain [48] and peripheral [49] IDO ...by systemic LPS injection in these studies may have originated from outside of the ...the ...
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Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation
... peripheral administration of orexin A by a subcutaneous osmotic pump improved the survival of mice to lipopolysaccharide (LPS)-induced endotoxin shock, decreasing the levels of multiple proinflammatory cytokines ...
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Systemic administration of ciliary neurotrophic factor induces cachexia in rodents
... Ciliary neurotrophic factor (CNTF) has previously been shown to promote the survival of several classes of neurons and glial. We report here that in addition to its effects on the nervous system, CNTF can induce potent ...
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The Effects of Local Fetal Brain Extract Administration on the Electromyogram of Crushed Sciatic Nerve in Rat
... that lead to cell death [10]. This motoneuronal death is characteristic of apoptosis, similar to that of neurons after trophic factor withdrawal [11]. The discovery and characterization of NGF led to the neurotrophic ...
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Biological Effects of Nanoparticles on Macrophage Polarization in the Tumor Microenvironment
... following systemic administration, there is considerable interest in identifying nanoparticle effects on TAM polarization, evaluating nanoparticle-induced TAM polarization effects on cancer treatment using ...
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Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice
... study, systemic administration of poncirin has shown to signifi- cantly increased the expression of Nrf2 and induction of HO-1, highlighting its importance in reducing the inflammatory pain through Nrf2 ...
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LIPOSOMES: AN EXCELLENT TOOL FOR DRUG DELIVERY SYSTEM
... The name liposome is derived from two Greek words: 'Lipos' meaning fat and 'Soma' meaning body. [1] Liposome was found by Alec Bangham of Babraham Institute in Cambridge, England in 1965. In 1990; drugs with liposome and ...
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Comparing the Impact of Autologous Platelet-rich Plasma and Granulocyte Colony Stimulating Factor on Pregnancy Outcome in Patients with Repeated Implantation Failure
... Presence of granulocyte colony stimulating fac- tor (GCSF) receptors in placental tissues, tropho- blastic cells and endometrial cells indicate the im- portance of this cytokine in implantation (14-16). The use of GCSF ...
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The Effects of Systemic Prescription of Amitriptyline on Orthodontic Tooth Movement Rate, Root Resorption and Alveolar Bone Remodeling in Dog
... bone formation and root resorption in dogs decreased with systemic administration of amitriptyline although this reduction was not statistically significant in comparison with the control group. This ...
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Alkali Therapy in Lactic Acidosis
... level, systemic [administration of] Carbicarb to treat severe acidosis resulted in systemic alkalinization without major changes in PaCO2 and intracellular pH in hepatocytes 16 , isolated heart ...
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Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation
... Furthermore, systemic administration of metformin significantly blocked morphine-induced microglial activation in the spinal cord and then attenuated the development of chronic morphine tolerance in ...
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Prelamin A and lamin A appear to be dispensable in the nuclear lamina
... The fact that the antisense oligonucleotide reduced prelamin A levels in cells and improved nuclear shape is exciting, raising the possibility that systemic administration of these antis[r] ...
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ANTI EDEMATOUS AND ANTIHYPERALGESIC ACTIVITIES OF ROSUVASTATIN IN INFLAMMATORY PAIN MODEL IN RATS
... difference in the pressure of the rat rhythm before and after treatment compared with the control group, d (g), in the Von Frey test (p <0, 01; single- phase ANOVA) (Fig. 4A - large chart). Rosuvastatin reaches ...
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Antinociceptive effects of lacosamide on spinal neuronal and behavioural measures of pain in a rat model of osteoarthritis
... LCM produced a significant and profound dose- dependent inhibition of many electrophysiological and be- havioural measures of nociception after spinal or systemic administration in MIA animals. These ...
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“A Review on In-Situ Nasal Gel Drug Delivery System” by Baban A. More, Harshad R. Mene, Rohit K. Pawar, Nitin S. Misal, Sagar S. Pathak, Kapil J. Shivsharan, India.
... drug administration is the oral route because of their ease of ...oral administration is not desirable when the drug undergoes significant degradation via first pass effect in ...preoral ...
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Formulation Development of Metformin Hydrochloride Sustained Release Tablets
... of administration among all the routes that have been employed for dosage ...of administration, belief that by oral administration of the drug is well ...for systemic delivery via the oral ...
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No Evidence That Therapeutic Systemic Corticosteroid Administration is Associated With Laminitis in Adult Horses Without Underlying Endocrine or Severe Systemic Disease
... corticosteroid administration (Anon 2005; Cohen & Carter 1992; Fredrick & Kehl 2000; Humber et al 1991; Lose 1980; McCluskey & Kavenagh 2004; Ryu et al 2004; Winfield et al ...severe systemic ...
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