Systems Pharmacology
A systems pharmacology approach to the adenosine A1 receptor
... of systems pharmacology. Here a systems pharmacology ap- proach is applied to adenosine receptor signalling in yeast with a view to understanding the contribution of the ligand, receptor and G ...
246
Enhancing the discovery and development of immunotherapies for cancer using quantitative and systems pharmacology: Interleukin-12 as a case study
... and systems pharmacology (QSP) has been proposed as a means to invigorate the drug discovery and development ...biological systems at increasing breadth and ...
14
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
... medicine systems pharmacology (HmSP) platform for the purpose of investigating how herbs interact with the human body from a molecular level to the organism level ...This systems/network pharmacol- ...
6
Improving nanotherapy delivery and action through image-guided systems pharmacology
... overall pharmacology of TNP is governed by an interconnected set of spatially defined and dynamic processes that benefit from a systems-level quantitative approach, and insights into the physiology have ...
30
Systems pharmacology of the amyloid cascade : unfolding oligomer modulation in Alzheimer's disease
... The extension of the systems pharmacology model to include tracer kinetic data provides additional insights into the underlying APP processing pathway. Our modelling results indicate that 49.1% of APP is ...
295
Towards personalized treatment of pain using a quantitative systems pharmacology approach
... Pain is a complex biopsychosocial phenomenon of which the intensity, location and duration depends on various underlying components. Treatment of pain is associated with considerable inter-individual variability, and as ...
7
Parsing interindividual drug variability: an emerging role for systems pharmacology
... growing appreciation that the reductionist approach to molecular-based drug design is failing because it insufficiently considers both the complexity of the interactions between a drug and the human body and the ...
21
Systems pharmacology identifies drug targets for Stargardt disease–associated retinal degeneration
... quantitative systems pharmacology have emerged that integrate systems biology and pharmacology ...Moreover, systems pharmacology promises to identify new uses of existing drugs ...
17
Systems pharmacology approach for prediction of pulmonary and systemic pharmacokinetics and receptor occupancy of inhaled drugs
... Pulmonary drug disposition after inhalation is complex involving mechanisms, such as regional drug deposition, dissolution, and mucociliary clearance. This study aimed to develop a systems pharmacology ...
11
A novel systems pharmacology model for herbal medicine injection: a case using reduning injection
... of systems pharmacology [5]. The term systems pharmacology describes a field of study that applies the systems biology and PK/PD to provide a quantitative frame-work for understanding ...
19
Quantitative systems pharmacology analysis of drug combination and scaling to humans: the interaction between noradrenaline and vasopressin in vasoconstriction
... quantitative systems pharmacology model structure provides a translational framework to mechanistically inter- pret and predict drug–drug interactions and is of significant value to rationally optimize novel ...
14
Systems pharmacology–based integration of human and mouse data for drug repurposing to treat thoracic aneurysms
... progression. Systems pharmacology approaches that consider drug targets as nodes within cellular regulatory networks can use differentially expressed genes (DEGs) to predict dysregulated SCPs that underlie ...
17
Systems Pharmacology: Defining the Interactions of Drug Combinations
... state-of-the-art systems pharmacology approaches to enable rational iden- tification of combination ...a systems level, can enable understanding of drug interactions at the molecular, cellular, phys- ...
24
Systems pharmacology and genome medicine: a future perspective
... and systems pharmacology (in ...to systems pharmacology’ as top-down and ‘systems pharmacology to genome medicine’ as ...and systems pharmacology. Systems ...
9
Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models : Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network
... resources, inadequate model documentation, and a decline in the direct submission of models to those repositories by their authors. Published models tend to be generated de novo rather than being the result of an ...
15
A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug drug interactions
... In this paper, a liver model will be presented that takes into account three major DDI mechanisms of metabolic enzymes; competitive inhibition, mechanism based inhibition MBI and inducti[r] ...
28
A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation
... One-way ANOVA (p ≤ 0.05) was used as the first thresh- old for differences across treatment groups. Then, a two-tailed Student’s t test was performed comparing the LPS and control groups and proteins that showed statis- ...
20
On the Physiology and Pharmacology of the Earthworm Gut
... Because the crop and gizzard has certain advantages as a test preparation for the assay of acetylcholine, experiments were made to determine the action of some other substances likely to[r] ...
14
EVALUATION OF STRESS IN EXPERIMENTAL PHARMACOLOGY
... Neonatal isolation stress model has be used extensively to demonstrate the effect of early lifetime stress on vulnerability to addiction 36, and response to psychostimulants by impairmen[r] ...
9
Antimalarial pharmacology and therapeutics of atovaquone
... Despite the extensive use of Atovaquone-Proguanil, there remains a considerable knowledge gap concerning its pharmacology. The rollout of generics following the expiry of the patent will undoubtedly see an ...
18