T-box transcription factor
The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis
... the T-box transcription factor, TBX3, was found to correlate with later stages of melanoma, and like AKT3, TBX3 promotes melanoma formation and invasion by, in part, directly repressing ...
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T Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration
... Cell migration is a crucial feature of organogenesis and tissue formation during embryogenesis. Likewise, in the developing brain, many classes of newly formed neurons migrate in stereotypic patterns in order to ...
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The T box transcription factor Brachyury promotes epithelial mesenchymal transition in human tumor cells
... the T-box transcription factor Brachyury induces in tumor cells epithelial-mesenchymal transition (EMT), an impor- tant step in the progression of primary tumors toward ...E-cadherin ...
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Original Article T-box transcription factor 21 expression in breast cancer and its relationship with prognosis
... as T-box transcription factor 21, is a key lineage-defining transcription factor expressed in immune ...cells. T-bet plays critical roles in the differentiation of Th1 ...
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Nickel Nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor, TBX21 (T-bet)
... and T-bet −/− mice as deter- mined by pathology scoring of H&E-stained lung ...and T-bet −/− mice (Figure 3). For example, we found that T-bet −/− mice had spontaneous eosinophil infiltration as ...
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The T-box transcription factor TBX3 drives proliferation by direct repression of the p21WAF1 cyclin-dependent kinase inhibitor
... This study provides a full characterisation of the repression of p21 by TBX3 in chondrosarcoma cells. Consistent with p21 being a direct TBX3 target gene, the TBX3 DNA binding domain (T-box) was shown to be ...
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The T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression
... of T-box proteins to a half consensus site of the E-cadherin promoter ...ger transcription factors, repress E-cadherin expression by its sequence-specific DNA binding abilities and competes with ...
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Muscle Cell Fate Choice Requires the T-Box Transcription Factor Midline in Drosophila
... Midline (Mid) is the Drosophila ortholog of vertebrate Tbx20. It is one of eight Drosophila T-box transcription factors and plays a fundamental role in cell fate choice in several differentiating ...
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<p>LncRNA <em>TBX5-AS1</em> Regulates the Tumor Progression Through the PI3K/AKT Pathway in Non-Small Cell Lung Cancer</p>
... Long non-coding RNAs (lncRNAs) are increasingly implicated as gene regulators in diverse diseases. 7–9 Notably, lncRNAs are considered to play important roles in disease progression of various tumors, such as NSCLC, ...
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Expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas
... (T-box transcription factor-4 [TBX4], heat shock protein-60 [HSP60], and Parkinson protein-7 [DJ-1]) identified in previous proteomic studies in IHCC tumors were immunohistochemically ...
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Specification of the C elegans MS blastomere by the T box factor TBX 35
... In C. elegans, many mesodermal cell types are made by descendants of the progenitor MS, born at the seven-cell stage of embryonic development. Descendants of MS contribute to body wall muscle and to the posterior half of ...
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Defective Tbx2 dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice
... of T-box 2 (Tbx2) (15), a T-box factor required for the development of the AV canal ...Hey transcription factors further establish the AV canal phenotype ...expressed ...
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Development of Natural Killer Cells Regulated by T-Box Transcription Factors
... Various transcription factors have been reported to alter NK cell development, but the definitive transcriptional program governing this process is not well ...the T-box transcription factors ...
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In vivo regulation of the zebrafish endoderm progenitor niche by T box transcription factors
... 2012). T is required for normal mesoderm formation, with notochord and posterior somites failing to differentiate in mutant mice (Dobro- volskaı¨a-Zavadskaı¨a, ...Another T-box TF, Tbx16, plays a key ...
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Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy
... FOXO3 transcription factors prevent cardiac hypertrophy by stimulating the expres- sion of atrogin-I (an E3 ubiquitin ligase) that facilitates the inhibition of calcineurin/nuclear factor of activated ...
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T box transcription factors and their roles in regulatory hierarchies in the developing heart
... a T-box binding element (TBE) and, to a lesser extent, on a Nkx2-5-binding element ...chamber factor Tbx5 from the TBE/NKE element of the Nppa gene in non-chamber myocardium, forming a repressive ...
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Regulatory integration of Hox factor activity with T box factors in limb development
... To assess the genomic target sites occupied by Tbx4 and Hoxc10 in limb buds, we performed ChIPseq for both proteins in embryonic day (E) 11.5 HL buds. We performed duplicate ChIPseq experiments for Tbx4 and Hoxc10 with ...
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Promyelocytic leukaemia protein isoform II and mild heat stress compromise human adenovirus type 5 gene expression
... other factor that affected the switch between those two phases with L1 to L5- plasmid is the loss of Ad5 DNA replication during the natural ...where transcription of RNA Polymerase III ...
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Transcriptional Control and Population Dynamics of Antiviral CD8+ T Cell Responses
... Two T-box transcription factors, T-bet and Eomesodermin (Eomes), have critical roles in the development of natural killer cells and the differentiation of CD8 + T cells in response to ...
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Characterization of clonal and regenerative perivascular stem cells in human endometrium
... Decidualization is associated with the influx of maternal natural killer cells that are present during spiral artery remodelling and eventually decrease during mid- gestation. In mice, it was shown that uNK cells are ...
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