T-box transcription factor 5
<p>LncRNA <em>TBX5-AS1</em> Regulates the Tumor Progression Through the PI3K/AKT Pathway in Non-Small Cell Lung Cancer</p>
... Long non-coding RNAs (lncRNAs) are increasingly implicated as gene regulators in diverse diseases. 7–9 Notably, lncRNAs are considered to play important roles in disease progression of various tumors, such as NSCLC, ...
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Original Article T-box transcription factor 21 expression in breast cancer and its relationship with prognosis
... as T-box transcription factor 21, is a key lineage-defining transcription factor expressed in immune ...cells. T-bet plays critical roles in the differentiation of Th1 ...
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T box transcription factors and their roles in regulatory hierarchies in the developing heart
... a T-box binding element (TBE) and, to a lesser extent, on a Nkx2-5-binding element ...chamber factor Tbx5 from the TBE/NKE element of the Nppa gene in non-chamber myocardium, forming a ...
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The T-box transcription factor TBX3 drives proliferation by direct repression of the p21WAF1 cyclin-dependent kinase inhibitor
... disrupted T-element in the initiator of the p21 promoter generated by site-directed mutagen- esis as previously described ...primer 5 ′ CATTACCAAGTCGGGAgGGgGAATGTTTCCTCC ATTTAAAG 3 ′ ...SP190A: 5 ′ ...
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The T box transcription factor Brachyury promotes epithelial mesenchymal transition in human tumor cells
... Brachyury inhibition results in loss of mesenchymal markers and reduced migration and invasion of tumor cells. The levels of Brachyury mRNA expression were analyzed by real-time PCR in various human tumor cell lines ...
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T Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration
... corresponded to the position of facial BM neurons (VII) in r4 (Fig. 1M). However, Tbx20 was not detected in the somatic motor (SM) population of abducens (VI) motor neurons (Fig. 1P, and see Fig. S1 in the supplementary ...
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The T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression
... forward 5’-GAC GCA AAA GAA CGT TCT GAC-3’ and reverse 5’- AGG ACT GCG TGG TGA TAC AG-3; Snail, forward 5’-ACT CGG TAC CAG TCT ACT ATC-3’ and reverse 5’-TGG CGC GAA TTT TTA CCC TTC-3’; Slug, ...
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Nickel Nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor, TBX21 (T-bet)
... in T-bet −/− mice that were not exposed to NiNPs, but did find spontaneously in- creased numbers of eosinophils in the BALF from T-bet −/− mice, which is characteristic of allergic ...the T-bet −/− , ...
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Muscle Cell Fate Choice Requires the T-Box Transcription Factor Midline in Drosophila
... We sought to test the above hypothesis by determining whether persistent expression in LT3 was sufficient to drive it to adopt an LT4 like morphology. We found that twi-GAL4, Mef2-GAL4, and 24B-GAL4-directed Mid at 25° ...
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The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis
... Melanoma is derived from melanocytes and while its early diagnosis and excision results in a five- year survival rate of 99%, the treatment of metastatic melanoma has been mostly ineffective, with a five- year survival ...
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Defective Tbx2 dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice
... of T-box 2 (Tbx2) (15), a T-box factor required for the development of the AV canal ...Hey transcription factors further establish the AV canal phenotype ...expressed ...
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In vivo regulation of the zebrafish endoderm progenitor niche by T box transcription factors
... T-box transcription factors T/Brachyury homolog A (Ta) and Tbx16 are essential for correct mesoderm development in ...homeodomain transcription factor Mixl1, which is absolutely ...
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Forkhead Box Transcription Factor Regulation and Lipid Accumulation by Hepatitis C Virus
... forkhead box transcription fac- tors, including FoxO1 and FoxA2, which play key roles in gluconeogenesis and  -oxidation of fatty acid, ...forkhead box transcription factors in modulating ...
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The human T transcription factor: A study of genetics and function
... posterior m esoderm (Rashbass et a l , 1991; Beddington et al., 1992; W ilson et a l , 1993; W ilson et a l , 1995). It was suggested that T affects cell m igration by regulating genes involved in cell adhesion, ...
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Expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas
... (T-box transcription factor-4 [TBX4], heat shock protein-60 [HSP60], and Parkinson protein-7 [DJ-1]) identified in previous proteomic studies in IHCC tumors were immunohistochemically ...
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HYPOXIA INDUCIBLE FACTOR AND OSMOREGULATORY MOLECULES AFFECT CELL BLEBBING; IMPLICATIONS FOR SENESCENCE AND AGEING PROCESS
... inducible factor and ageing: Ageing cellular physiology and gene expression in response to changing oxygen availability is essential for ...inducible factor (HIF) is highly conserved transcriptional ...
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Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy
... expressions of peroxisome proliferator activated recep- tor (PPAR)α, myosin heavy chain (MHC)-β, and tumor necrosis factor (TNF)-α [79]. In addition, deficiency of muscle ring-finger protein (MuRF)2, an ubiquitin ...
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MADS-Box Transcription Factor Mig1 Is Required for Infectious Growth in Magnaporthe grisea
... However, transcription factors activated by these MAP kinases are not well ...MADS-box transcription factor homologous to Saccharomyces cerevisiae ...MADS box had no effect on the ...
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Transcriptional Control and Population Dynamics of Antiviral CD8+ T Cell Responses
... negative T cells in the setting of autoimmune Autoimmune Lymphoproliferative Syndrome (ALPS) (Kinjyo et al., 2010). One consistent feature in these disparate settings is that Eomes is expressed in cells undergoing ...
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Virulence Factor NSs of Rift Valley Fever Virus Recruits the F-Box Protein FBXO3 To Degrade Subunit p62 of General Transcription Factor TFIIH
... an MOI of 5 and lysed after overnight incubation. A recombinant RVFV encoding the EGFP gene fused with a C-terminal TAP tag served as a negative control. TAP tag-purified protein complexes were analyzed by ...
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