T-cell acute lymphoblastic leukemia
Targeting IRAK1 in T-Cell acute lymphoblastic leukemia
... T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy resulting from the transformation of T-cell progenitors at various stages of ...
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Phenothiazines induce PP2A mediated apoptosis in T cell acute lymphoblastic leukemia
... T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer that is frequently associated with activating mutations in NOTCH1 and dysregulation of ...human T-ALL ...
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Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia
... and acute renal failure secondary to spontaneous tumor lysis syndrome in the setting of T-cell acute lymphoblastic ...and acute renal failure when found in conjunction with ...
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Subset derivation of T cell acute lymphoblastic leukemia in man
... blood T cells can be characterized as belonging to either the TH+2 or TH-2 T-cell ...of T cells are TH+2, whereas 80% are TH- 2 utilizing specific ...human T-cell acute ...
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Induction of human B cell antigens in non T cell acute lymphoblastic leukemia
... non-T cell acute lymphoblastic leukemia (ALL) express an antigen (B1) found on all normal B ...Non-T cell ALL lines and tumor cells isolated from patients with ...
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WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia
... T-cell acute lymphoblastic leukemia (T-ALL) is a lym- phoid malignancy caused by the oncogenic transforma- tion of immature T-cell progenitors with poor ...[1]. ...
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Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia
... T cell acute lymphoblastic leukemia (T-ALL) result from an aberrant accumulation of immature T cells bearing multiple oncogenic lesions in blood and BM ...6] T-ALL ...
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Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways
... Abstract: T-cell acute lymphoblastic leukemia (T-ALL) as a prevalent hematologic malignancy is one of the most common malignant tumors worldwide in ...inhibit T-ALL ...
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P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines
... with T cell acute lymphoblastic leukemia (T-ALL) were screened for mutations of the p53 tumor suppressor ...of T-ALL relapse patient ...B cell line (HABL) was ...
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Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia
... pediatric T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem and is thought to be associated with clonal selection during ...with T-ALL ...
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Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia
... various T-cell malignancies and appear to correlate with a relatively high intracellular concentration of ara-GTP compared to ...refractory T-cell acute lymphoblastic ...
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Mutations increased overexpression of Notch 1 in T-cell acute lymphoblastic leukemia
... T-cell acute lymphoblastic leukemia (T-ALL) which occurs mainly via the proliferation of malignant T cell clones, accounts for 15% of newly diagnosed ALL cases in ...
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SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines
... 141 leukemia/lymphoma cell lines of T-, B- and myeloid cell origin to detect SET-NUP214 positive ...A T-ALL cell line LOUCY (1/43 T cell lines tested) and an AML ...
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Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China
... [12–15]. T- ALL patients are more likely to have a worse steroid re- sponse than B-ALL patients [8, 10, ...established leukemia groups [19 – ...of T-cell receptor (TCR) and clone-specific ...
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The molecular basis of T cell acute lymphoblastic leukemia
... T cell acute lymphoblastic leukemias (T-ALLs) are aggressive hema- tologic tumors resulting from the malignant transformation of T cell ...progenitors. T-ALL ...
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Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies
... protein. T-ALL cells were treated with IRAK1/4 inhibitor, TLR1-TLR2 ligand, or DMSO, followed by the addition of cycloheximide (CHX), to inhibit protein translation over the course of 10 ...
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MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia
... pediatric T-cell acute lymphoblastic leukemias ...pediatric T-ALL, MYCN-expressing samples were found almost exclusively in the TAL1-positive ...in T-ALL cell lines ...
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Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas
... human T cell acute lymphoblastic leukemia (T-ALL) [1–3] and several murine T-ALL models, including ATM − / − thymic lymphomas [4 – ...murine T-ALLs retain at least ...
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T cell receptor delta gene rearrangements in acute lymphoblastic leukemia
... analyzed T cell receptor (TCR) delta gene rearrangement in 19 patients with T cell acute lymphoblastic leukemia (T-ALL) and 29 patients with B-precursor ...CD3- ...
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Expression of the polycomb group gene Bmi1 does not affect the prognosis of pediatric acute lymphoblastic leukemia
... course, cell profile, and ...In acute lymphoblastic leukemia, it was reported that CD90+/CD110+ cells in acute lymphoblastic T-cell leu- kemia, and ...
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