T Cell Anergy
Original Article DGKα DNA vaccine relieves airway allergic inflammation in asthma model possibly via induction of T cell anergy
... of T cell immune tolerance is thought to be a good method for treatment of ...following T-cell receptor engagement and prevent T cell hyperactiva- tion, thus playing important ...
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Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft versus host disease
... the cell culture (Figure 5d). Although IL-2 appears to reverse T cell anergy in var- ious T cell culture systems, its effect in the regulation of T cell ...
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The PPARα pathway in Vγ9Vδ2 T cell anergy
... V9V2 T cell lineage in humans and non-human primates [7, 8, ...V9V2 T cells from subjects injected with ...V9V2 T cell response to BrHPP [7, ...V9V2 T cells were then ...
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CD8<sup>+</sup> memory T-cell inflation renders compromised CD4<sup>+</sup> T-cell-dependent CD8<sup>+</sup> T-cell immunity via naïve T-cell anergy
... after T-cell transfer. (B) 90 days after T-cell transfer, blood samples from Ova-mT B6 mice were stained with PE-Ova tetramer, FITC-CD8 Ab, and PE-Cy5-Abs specific for CD44, CD62L, or IL7R, ...
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Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL 4 dependent mechanism
... NOD T cells, and that the IL-4 secreted as a consequence of this stimulation is neutralized by ...mononuclear cell infiltration was scored independently by two observers as follows: 0, normal; 1, ...
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Signaling through CD28 and CTLA 4 controls two distinct forms of T cell anergy
... on cell division. T cell receptor–coupled mitogenic signals are amplified by signals transduced through CD28 and are opposed by signals transduced through CTLA-4 (5, ...responding T cells; ...
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T cells presenting viral antigens or autoantigens induce cytotoxic T cell anergy
... CDR2 inclusion bodies. The full-length coding sequence of mouse Cdr2 was ligated into the bacterial expression vector pET-28c (EMD Millipore) to create pET28-CDR2. This plasmid was transformed into Rosetta 2 (DE3) (EMD ...
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Glycolipid antigen induces long term natural killer T cell anergy in mice
... NKT cell anergy is predominantly NKT cell autonomous and suggest that chronic stimulation with α-Gal- Cer is not required for maintenance of the anergic ...
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Genomics of rare genetic diseases—experiences from India
... B cell expansion with NF- κ B and T cell anergy; CFC: Clotting factor concentrates; CME: Continuing medical education; COL17A1: Collagen type XVII α 1; CSIR: Council of Scientific and ...
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Schistosoma mansoni worms induce anergy of T cells via selective up regulation of programmed death ligand 1 on macrophages
... of T cells to facilitate their survival within ...suppress T cell ...ⴙ T cells are ...induced T cell anergy at 4 wk, which was replaced after egg laying by T ...
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Dysregulation of Circular Antigen Specific T Cells Anergy in Autoimmune Vitiligo
... totoxic T cell (CTL) proliferation was significantly decreased after cultivation with Tregs from healthy individuals (p < ...that T cell anergy with Tregs dysfunction may participate ...
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Epitope specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL 2 and IL 15 in vitro
... tide T cell epitopes, which are recognized by both allergic and non-allergic bee venom sensitized ...epitope-specific T cell and cytokine re- sponses in PBMC of bee sting allergic patients ...
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T-Cell Receptor-Mediated Anergy of a Human Immunodeficiency Virus (HIV) gp120-Specific CD4+ Cytotoxic T-Cell Clone, Induced by a Natural HIV Type 1 Variant Peptide
... anergized T cells to heteroclitic peptides, which are essentially mutated versions of the native peptide antigen that can stim- ulate T cells more efficiently than the native peptide ...vivo-tolerized ...
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Type II NKT cell–mediated anergy induction in type I NKT cells prevents inflammatory liver disease
... Because of the paucity of known self lipid–reactive ligands for NKT cells, interactions among distinct NKT cell subsets as well as immune consequences following recognition of self glycolipids have not previously ...
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Interleukin 2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity
... immunomanipulation, using the murine model of experimental autoimmune uveoretinitis (EAU) induced by immunization with the retinal antigen interphotoreceptor retinoid binding protein (IRBP). Three feedings of 0.2 mg IRBP ...
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Human auto antiidiotypes regulating T cell mediated reactivity to tetanus toxoid
... vitro T cell blastogenic responses were ...on T cell ...antigen-specific T cell ...of T cell reactivity in vivo and in ...cutaneous anergy beyond six months, ...
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Rheumatoid arthritis synovial T cells regulate transcription of several genes associated with antigen induced anergy
... that T cells are more numerous in RA than in ReA synovium ...are T-cell ...three anergy-related transcripts that demonstrated reduced transcription in RA compared with ...RA T cells to ...
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Regulation of autoreactive B cells during innate immune responses
... experienced B cells. We recently identified a tolerance mechanism that selectively represses Ig secretion by autoreactive B cells during innate immune responses. We find that chronically antigen-experienced B cells are ...
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Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells
... the cell pellet resuspended in FACS buffer (PBS w/o Ca ++ /Mg ++ , 1% BSA), incubated with anti-mouse CD16/CD32 mAb (clone 93; Biolegend, San Diego, CA, USA), and aliquots of 1 × 10 6 cells in ...
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Specific T cell activation in an unspecific T cell repertoire
... the T-cell antigen receptor ...Since T-cells must avoid re- sponding to antigens not associated with harm (such as autoantigens), an intuitively obvious starting point is the assumption that TCR ...
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