T cell-(in)dependent antigen
Evaluation of Immunomodulatory Potential of Amaranthus Dubius Leaf on Rodent Models
... when antigen activates sensitized TDTH ...to T cell dependent antigen revealed the stimulatory effect of aqueous extract of Senna on T ...the antigen (in this case SRBC) ...
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Induction of CD4+ T cell–dependent antitumor immunity by TAT mediated tumor antigen delivery into dendritic cells
... Dendritic cell–based (DC-based) im- munotherapy represents a promising approach, since DCs are potent professional antigen-presenting cells capable of initiating host immune responses against cancer and ...
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Tumour cell generation of inducible regulatory T-cells in multiple myeloma is contact-dependent and antigen-presenting cell-independent
... - T-cells were isolated from PB and co-cultured with mitomycin C-treated HMCL for 7 days with and without the specific TGFb antagonist, Latency Associated Peptide (LAP) and an anti-TGFb monoclonal antibody ...Reg ...
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Simian Virus 40-Host Cell Interaction During Lytic Infection
... It has been postulated that besides requiring the presence of T-antigen, the replication of SV40 DNA is dependent upon an event in the host cell cycle occurring in late GI or early S pha[r] ...
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Plasmacytoid dendritic cells induce NK cell–dependent, tumor antigen–specific T cell cross priming and tumor regression in mice
... This T cell cross-priming was mediated by conventional DCs (cDCs) and was completely dependent upon the early recruitment and activation of NK cells at the tumor ...NK cell recruitment was ...
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In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice
... CD4+ T cell lines were generated from the spleens of diabetic NOD mice against crude membrane preparations derived from a rat ...individual T cell clones from the Th1 line included reactivity ...
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Antigen-Dependent and -Independent Mechanisms of T and B Cell Hyperactivation during Chronic HIV-1 Infection
... B cell activation with non-HIV ...⫹ T cells are preferential targets of the virus and are massively depleted early during infection (21, 56, ...chronic T cell activation in HIV infection, it ...
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TLR dependent T cell activation in autoimmunity
... as antigen presenting cells (APCs) for naïve T cells, but also by providing the cytokine stimulus (the third signal) for T cell activation 1-2 ...of T cell-promoting cytokines 1 ...
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MHCII Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion
... and T cell interactions in allergic models, but similar antigen-dependent ILC2:T cell crosstalk might also be important for the potentiation of type- 2 responses in ...human ...
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Maintenance of antigen specificity by human interleukin 2 dependent T cell lines Use of antigen presenting cells and OKT3 antibody in the absence of antigen
... of T cells obtained from localized anatomic sites of pathology may offer a new approach to the investigation of certain human autoimmune ...interleukin-2-dependent T cell cloning is to be ...
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Cyclin-dependent kinase regulation of the replication functions of polyomavirus large T antigen.
... host cell, or if they do not, then how do they induce the host which is in a resting mode to initiate DNA synthesis? Py T Ag has been shown to bind to pRB (9), harboring a specific sequence which by ...
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The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells.
... At 32°C, these cells arrest in the G phase of the cell cycle, and the ability of the SV40 large T antigen to overcome this temperature-dependent block in cell division was examined.. The[r] ...
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Induction of minor Histocompatibility antigen specific T helper, but not T cytotoxic response is dependent on the source of antigen presentation cells.
... Unlike the posttransplant T-cell lines induced with host PBLs, none of the T-cell cultures induced with host EBV-LCLs as APCs showed proliferative activity against host PBLs as stimulato[r] ...
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Vesicular stomatitis virus Indiana glycoprotein as a T-cell-dependent and -independent antigen.
... A neutralizing IgG titer was seen when nude mice transfused with the M-specific line were injected with infectious VSV and not with UV-inactivated VSV; the latter also does not induce an[r] ...
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T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
... ⫹ T-cells Exhibit Substantial Diversity in Their Ability to Recognize Natural Tumor Epitopes—It is established that the ELAGIGILTV and EAAGIGILTV peptides exhibit differential binding to HLA A*0201 (34, ...higher ...
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Antigen-Specific T-Cell Responses of Leprosy Patients
... Leprosy is a chronic disease with a wide range of clinical outcomes. Leprosy patients are predominantly diagnosed by the appearance of disease signs, but they can also be charac- terized by the physical and histological ...
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Recombinative events of the T cell antigen receptor delta gene in peripheral T cell lymphomas
... productive rearrangements could be ascribed to V delta 1J delta 1 joining in 3 cases and VJ delta 1 joining in 2 cases according to the combined pattern of DNA hybridization with the appropriate probes and of cell ...
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Review Article The Role of T Cells in Osteoporosis, an Update
... i t y ( B M D ) , m i c r o a r c h i t e c t u r a l deterioration of bone tissue, and a consequential increase in bone fragility and susceptibility to fracture ...a cell type that builds ...
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Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation.
... (Lymphocult T, Biotest; Serum Institute, Frankfurt, Germany) was added, and the cells were grown for an additional week before freezing in culture media containing 10% dimethyl sul- ...of T-cell line ...
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ATP-Dependent Simian Virus 40 T-Antigen–Hsc70 Complex Formation
... large T antigen is a multifunctional oncoprotein that is required for numerous viral functions and the induction of cellular ...transformation. T antigen contains a J domain that is required ...
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