T-cell-independent
Protective Vaccine-Induced CD4+ T Cell-Independent B Cell Responses against Rabies Infection
... B cell phenotype (B220 ⴙ GL7 hi CD95 hi ) are formed, indicat- ing a potential role for T cell-independent and early extrafollicular T cell-dependent antibody responses in the ...
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Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner
... showed that a relatively lower dose of LNT treatments (such as 1.0 mg/kg) more potently reduced tumor vascular function than that of a relatively higher dose (such as 5.0 mg/kg). Furthermore, our study suggests that LNT ...
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Long Lasting T Cell Independent IgG Responses Require MyD88 Mediated Pathways and Are Maintained by High Levels of Virus Persistence
... acute T cell-independent (TI) B cell responses due to their repetitive epitopes and the induction of innate ...Nevertheless, T cell help is thought necessary for the development ...
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CD20 deficiency in humans results in impaired T cell–independent antibody responses
... B cell differentiation antigen identified, and CD20-specific mAbs are commonly used for the treatment of B cell malignancies and autoantibody-mediated autoimmune ...B cell physiology has remained ...
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T cell independent secondary antibody responses to the envelope protein of simian immunodeficiency virus
... B cell is a strictly T cell-dependent immune reaction [31,32,36], there is another publication demonstrating that T-cell-independent humoral immune responses to enveloped viruses ...
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CD4+ T cell–independent vaccination against Pneumocystis carinii in mice
... + T lymphocytes. Moreover, deficient CD4 + T lymphocytes impair vaccination approaches to prevent opportunistic ...+ T cell–independent vaccine approach to a prototypic AIDS-defining ...
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Induction of CD4+ T-Cell-Independent Immunoglobulin Responses by Inactivated Influenza Virus
... II-restricted T-cell ...II-dependent T-cell help ...only T-cell-dependent antibody responses, which include both IgM and IgG responses (21, ...
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T cell–independent B cell activation induces immunosuppressive sialylated IgG antibodies
... of T cell–dependent (TD) protein antigens and proinflammatory ...conditions. T cell–independent (TI) B cell activation via B cell receptor (BCR) crosslinking through ...
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CD4+ T cell–independent DNA vaccination against opportunistic infections
... + T lymphocytes profoundly perturbs host defenses and impairs immunogenicity of ...+ T lymphocytes and critical for T cell helper function, can elicit significant titers of antigen-specific ...
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Hyper IgM immunodeficiency A primary dysfunction of B lymphocyte isotype switching
... both T cell-dependent and T-cell independent polyclonal B cell activators resulted in normal numbers of IgM plasma cells and IgM secretion in cultures, but failed to induce any ...
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Subdominant CD8 T-Cell Epitopes Account for Protection against Cytomegalovirus Independent of Immunodomination
... in IE3, dominating in C57BL/6 mice (40). These findings in the two most extensively studied mouse models of CMV infection compare well to the hCMV-specific CD8-T M -cell repertoires in humans that were ...
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TAP independent self peptides enhance T cell recognition of immune escaped tumors
... TEIPP T cells, we examined the capability of vacci- nation approaches to induce TEIPP T cell responses in a WT background in which all antigen-present- ing cells are TAP ...the T cells, ...
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Non-Antigen-Specific B-Cell Activation following Murine Gammaherpesvirus Infection Is CD4 Independent In Vitro but CD4 Dependent In Vivo
... The in vitro infection protocol also stimulated Ig production, which was detectable from 2 days after infection by ELISA of culture supernatants (Fig. 2A). The Ig detected was predomi- nantly of the IgM class, and ...
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T cell receptor independent immunosuppression induced by dexamethasone in murine T helper cells
... model cell system, namely the murine Th2 clone ...anti-T cell receptor (TCR) mAb ...TCR independent and involves an early cytokine-signalling ...
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Immortalization of T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Is Independent of the Tax-CBP/p300 Interaction
... experiment in which each clone was transfected in duplicate and an additional empty vector was transfected as a control are shown in Fig. 3. Like the cells transfected with the ACH.pcTax molecular clones, the cells ...
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Tumour cell generation of inducible regulatory T-cells in multiple myeloma is contact-dependent and antigen-presenting cell-independent
... regulatory cell compartment in an attempt to evade immune surveillance ...regulatory cell compartments have been described ...regulatory T-cell population has remained ...tumour cell in ...
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A strongly selected mutation in the HIV 1 genome is independent of T cell responses and neutralizing antibodies
... only the K43R mutation was fully documented here, we found other possible examples of selected escapes that were not within an epitope stimulating a measur- able T cell response in our previous studies [5, ...
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Tax 1-Independent Induction of Vascular Endothelial Growth Factor in Adult T-Cell Leukemia Caused by Human T-Cell Leukemia Virus Type 1
... Human T-cell leukemia virus type 1 (HTLV-1) is the etio- logical agent of adult T-cell leukemia (ATL) and a neurode- generative disease termed tropical spastic paraparesis/HTLV- 1-associated ...
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Sequence Diversity in the pe pgrs Genes of Mycobacterium tuberculosis Is Independent of Human T Cell Recognition
... DNA sequence diversity and selection in PE_PGRS proteins. To characterize the sequence diversity of PE_PGRS proteins and the impact of human T cell recognition, we selected 27 PE_PGRS family members for ...
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AMPK-dependent and independent effects of AICAR and compound C on T-cell responses
... in T cells using CD4-Cre-AMPK fl/fl mice, we confirmed that AICAR and Compound C can indeed activate or inhibit AMPK, respectively, in T cells from WT mice (Figure ...KO T cell death, but ...
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