T-cell receptor
Immunodominance of a low affinity major histocompatibility complex binding myelin basic protein epitope (residues 111 129) in HLA DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire
... a T cell-mediated process targeting mye- lin components. The T cell response to one candidate au- toantigen, myelin basic protein (MBP), in the context of HLA-DR15Dw2, has been previously ...
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Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts
... 1 T lymphocytes are an important compo- nent of the cellular response in allograft ...b T cell receptor a / b (TCR), g / d TCR, or ...of T cells, including ...are T cells that ...
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Epidermal Growth Factor Receptor Expression Licenses Type 2 Helper T Cells to Function in a T Cell Receptor Independent Fashion
... helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby contributing to host resis- tance in a T cell receptor (TCR)-independent ...factor receptor (EGFR) and of ...
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Sampling from T cell receptor repertoires
... 9. Niclas Thomas, Katharine Best, Mattia Cinelli, Shlomit Reich-Zeliger, Hilah Gal, Eric Shifrut, Asaf Madi, Nir F riedman, John Shawe-Taylor, and Benny Chain. Tracking global changes induced in the CD4 T ...
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Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance
... of T cell activation, but the effect of HIV antigen reduction on the T cell receptor (TCR) repertoire of epitope-specific T cell responses remains poorly defined ...
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Limited heterogeneity of T cell receptor BV usage in aplastic anemia
... CD8 T cell clones from a patient with AA and analyzed their T cell receptor (TCR) ...the T cell reper- toire in an individual patient and similarity at the molecular level ...
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Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium
... CD4+ T lymphocytes, and a genetic linkage to the MHC antigen HLA-DR4. Since T cells are restricted by class II MHC molecules such as DR4, this suggests a direct role for these CD4+ cells in ...investigate ...
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T cell receptor alpha chain gene rearrangements in B precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia Comparative study of T cell receptor gene rearrangement in childhood leukemia
... analyzed T cell receptor alpha-chain gene configuration using three genomic joining (J) region probes in 64 children with acute lymphoblastic leukemia ...18 T-ALLs were T3 positive; ...
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HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation
... CD4 T cell immuno- logical synapse, we pretreated SLBs containing gp120, OKT3, and ICAM-1 with human MAbs directed to different regions of ...CD4 T cells were then added and allowed to interact with ...
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Comparison of T cell receptor alpha, beta, and gamma gene rearrangement and expression in T cell acute lymphoblastic leukemia
... leukemic T cell lines (HSB2, CEM, and ...the T cell lines. All T-ALL and the three T cell lines exhibited both TCR-gamma and beta gene ...10 T-ALL and all T ...
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T cell receptor V beta gene bias in rheumatoid arthritis
... synovial T cells in patients with rheumatoid arthritis (RA) for biased utilization of T cell receptor (TCR) variable region (V) ...unselected T cell ...
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Allelic polymorphism in the T cell receptor and its impact on immune responses
... for T cell recognition (Davis and Bjorkman, ...the T cell response to infecting pathogens through presentation of a broad array of target epitopes (Lawlor et ...
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Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
... of T lymphocytes that contains clones responsive to tumor ...renal cell carcinoma (2) and glioma (3), it is not broadly applicable to multiple cancer types because of the low fre- quency of TILs within the ...
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T cell receptor repertoire of infiltrating T cells in lips of Sjögren's syndrome patients
... Infiltrating T cells around salivary glands in the lips of Sjögren's syndrome (SjS) patients are crucial in the pathogenesis of this ...infiltrating T cells, their T cell receptor ...
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Survivin specific T cell receptor targets tumor but not T cells
... adoptive T cell therapy with genetically engi- neered αβ T cell receptors (TCRs) has resulted in encouraging responses in some patients ...to T cell activation, resulting in ...
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Original Article Detection of immunoglobulin and T-cell receptor gene rearrangements in angioimmunoblastic T-cell lymphoma
... peripheral T-cell lympho- ma of the lymph node that accounts for 1-2% of non-Hodgkin’s lymphomas and approximately 15% of peripheral T-cell lymphomas ...
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Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1
... ⫹ T-cell responses, we selected well-defined, dominant epitopes for the three HLA-I alleles of interest: B*08-FLKE KGGL (B8-FL8), B*08-EIYKRWII (B8-EI8), A*02-SLYNTVATL (A2- SL9), and B*27-KRWIILGLNK ...⫹ ...
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Surface receptor Toso controls B cell–mediated regulation of T cell immunity
... regulate T cell responses in an antibody-independent ...pathogenic T cell responses was already suggested in 1996 by Jan- eway and colleagues, who showed that B cell–deficient mice ...
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Recombinative events of the T cell antigen receptor delta gene in peripheral T cell lymphomas
... productive rearrangements could be ascribed to V delta 1J delta 1 joining in 3 cases and VJ delta 1 joining in 2 cases according to the combined pattern of DNA hybridization with the appropriate probes and of cell ...
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Viral Modulation of T-Cell Receptor Signaling
... Since T cells represent the main site of HIV replication in vivo, per- haps it should not be surprising that HIV is a talented manip- ulator of T-cell ...to T-cell biology, it should ...
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