T cell receptor (TCR)
Alterations in T-Cell Receptor Vβ Repertoire of CD4 and CD8 T Lymphocytes in Human Immunodeficiency Virus-Infected Children
... the T-cell receptor (TCR) V  repertoire were assessed in the CD4 and CD8 T lymphocytes of human immunodeficiency virus (HIV)-infected children who were receiving therapy during the ...
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T cell receptor delta gene rearrangements in acute lymphoblastic leukemia
... the TCR-delta gene and genomic probes, we have analyzed T cell receptor (TCR) delta gene rearrangement in 19 patients with T cell acute lymphoblastic leukemia ...
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Restricted usage of T cell receptor V alpha V beta genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy
... infiltrating T cells and persistence of viral genomes in the myocardial tissue, we analyzed the expression of T cell receptor (TCR) V alpha and V beta genes as well as enterovirus ...
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Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance
... of T cell activation, but the effect of HIV antigen reduction on the T cell receptor (TCR) repertoire of epitope-specific T cell responses remains poorly defined ...
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Radiation leukemia virus-induced thymic lymphomas express a restricted repertoire of T-cell receptor V beta gene products.
... By the combined use of antibodies against the envelope glycoprotein gp7O of RadLV, the transformation-associated cell surface marker lC1l, and the CD3-T-cell receptor TCR complex, we fou[r] ...
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Regulation of the mature human T cell receptor gamma repertoire by biased V J gene rearrangement
... delta T cell repertoire, we generated T cell receptor gamma (TCR gamma) V domain-specific cDNA libraries from the peripheral lymphocytes of eight donors and sequenced a total of ...
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The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL.
... Cytotoxic T lymphocytes (CTL) appear to play an important role in the control of human cytomegalovirus (HCMV) in the normal virus carrier: previous studies have identified peripheral blood CD8 1 CTL specific for ...
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Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure
... of TCR and a basis of the cross-reactivity of T cells ...19-reactive T-cell clones to further probe their fine ...the T-cell clones expressing TCRBV13S1 ...of ...
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Improved Assessment of T-Cell Receptor (TCR) VB Repertoire in Clinical Specimens: Combination of TCR-CDR3 Spectratyping with Flow Cytometry-Based TCR VB Frequency Analysis
... each TCR VA or VB family, and the area under the curve for each individual CDR3 peak is ex- pressed as the percentage of the entire CDR3 ...each TCR VA/VB fam- ily; alternatively, the entire TCR VA ...
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T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone
... ⫹ T-cell clones derived from HIV-1-infected persons were used in these studies and were characterized as effective CD8 ⫹ T-cell clones (EC) or ineffective CD8 ⫹ T-cell clones ...
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T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
... effective T-cells are those that rec- ognize target cells bearing low densities of cognate pMHC on their surface ...defined T-cell antigens indicate that the best T-cell agonists are ...
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Presence of Oligoclonal T Cells in Cerebrospinal Fluid of a Child with Multiphasic Disseminated Encephalomyelitis following Hepatitis A Virus Infection
... of T cells, we amplified, cloned, and se- quenced -chain T-cell receptor (TCR) transcripts from the cerebrospinal fluid (CSF) and the peripheral blood of a 7-year- old female who ...
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Myelin basic protein specific T lymphocyte repertoire in multiple sclerosis Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones
... human T cell response to the myelin basic protein (MBP) has been studied with respect to T cell receptor (TCR) usage, HLA class II restriction elements, and epitope specificity ...
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Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis
... of T cell specificities in the synovial fluid of patients has been taken as evidence for a local stimulation of T ...the T cell receptor (TCR) repertoire of CD4+ T ...
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Functional T-Cell Deficiency in Adolescents Who Experience Serogroup C Meningococcal Disease despite Receiving the Meningococcal Serogroup C Conjugate Vaccine
... or T-cell ...mimic T-cell-independent B-cell stimulation by bacterial polysaccha- rides and the T-cell stimulation provided by the protein component of the conjugate ...of ...
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Clonal T cell responses in tumor infiltrating lymphocytes from both regressive and progressive regions of primary human malignant melanoma
... The T cell receptor (TCR) BV variable (V) gene repertoire of tumor infiltrating lymphocytes (TIL) found in progressive and regressive regions of the same primary human melanomas were ...
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Gene expression pattern of TCR repertoire and alteration expression of IL 17A gene of γδ T cells in patients with acute myocardial infarction
... And T cells are further subdivided into two major populations characterized by the surface expression of a T cell receptor (TCR) α chain and a β chain (αβ T cells) or a γ chain ...
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Therapeutic cancer vaccines
... adoptive T cell transfer ...transferred T cells (frequently expanded TILs) appears to determine the thera- peutic efficacy of ...of T cells transduced with an avidity -enhanced, ...
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Cells of the synovium in rheumatoid arthritis T lymphocytes
... of T-cell responses in rheumatoid arthritis (RA) is initiated by T-cell receptor (TCR) interaction with shared epitope major histocompatibility complex class II (MHCII-SE) and ...
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CRISPR-Cas, a robust gene-editing technology in the era of modern cancer immunotherapy
... tumor-specific T-cells into patients, a so called “adoptive cell transfer”, or ACT, ...allogeneic T-cells is dependent on the employment of a gene-editing tool to modify donor-extracted ...
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