T cells (Treg cells)
Regulatory T cells and control of the germinal centre response
... + cells lack interferon regu- latory factor (IRF)4 develop spontaneous GCs but are not a phenocopy of Foxp3-deficient mice ...of Treg biology that is essential for moderating the GC itself and that ...
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PC61 (Anti-CD25) Treatment Inhibits Influenza A Virus-Expanded Regulatory T Cells and Severe Lung Pathology during a Subsequent Heterologous Lymphocytic Choriomeningitis Virus Infection
... inflammation. T-regulatory (Treg) cells have been shown to be key mediators in balancing inflammation and in in- hibiting immune-mediated tissue damage, especially in organs like the lung and ...
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Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer
... tumor cells overcome disadvantaged hypoxic microenvironment by upregulating expression of CCL28 to recruit a specific Treg population at the tumor ...Treg cells. In earlier reports, ...
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T Cells with a CD4+CD25+ Regulatory Phenotype Suppress In Vitro Proliferation of Virus-Specific CD8+ T Cells during Chronic Hepatitis C Virus Infection
... ⫹ T-cell responses is specific for chronic HCV ...the Treg-mediated suppression of HCV- and influenza virus-specific CD8 ⫹ T-cell responses in persons with resolved HCV infection (Table 1) and of ...
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Review Article Regulatory T cells and B cells: implication on autoimmune diseases
... mice Treg cells can directly suppress B cell activation and proliferation ...activated T cells kill B cells through the emancipation of perforin and granzyme B by Treg ...that ...
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Regulatory T Cells Suppress In Vitro Proliferation of Virus-Specific CD8+ T Cells during Persistent Hepatitis C Virus Infection
... ⫹ T cells (13, 23), despite high-level viral replication and viral protein ...⫹ T-cell response may comprise 8% of total CD8 ⫹ T cells and include responses to at least eight separate ...
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Anti-inflammatory effects of interleukin-23 receptor cytokine- binding homology region rebalance T cell distribution in rodent collagen-induced arthritis
... on T cell function and distribution in the pathological process of RA in this study to differentiate the specificity and rationalize the potential benefits of targeting a specific signaling ...treatment, T ...
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The Research of Treg Cells: Progress and Challenge
... largely T cell mediated, that promotes specific unresponsiveness to donor ...for Treg cells is T cells, Nonetheless, recent studies have also demonstrated that Treg cells ...
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Original Article Orbital rhabdomyosarcoma tumor-associated antigen-specific T cells had a Th1-to-Treg ratio than hemaglutinin- and tetanus toxin-specific T cells
... toxin-specific T cells, is strongly suggesting that interactions with tumor antigens, likely inside the tumor microenvironment, can be inhibitory to adaptive T cell ...tumorigenic T cell ...
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Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice
... + T cells and neu- trophils (not shown) were comparable among healthy and treated ...NK cells was already observed after 6 days of treatment (not shown) and is in accordance with the reported time- ...
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Regulatory T cells in vitiligo: Implications for pathogenesis and therapeutics
... governing Treg cell development and function [28-30]. FoxP3 down-regulates T cell activation and cytokine genes ...suppressive Treg cell phenotype [31,32]. FoxP3 suppresses the effector functions of ...
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Itch expression by Treg cells controls Th2 inflammatory responses
... reactive T cells (1, ...of Treg cells (3, ...6). Treg cells are generated in the thymus and migrate into the periphery to become naturally occurring Treg (nTreg) ...
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Immunosuppressive Treg cells acquire the phenotype of effector T cells in chronic lymphocytic leukemia patients
... that T cells abnormalities may con- tribute to the immunopathogenesis of CLL by support- ing leukemic clone proliferation and survival [8, 9, ...this T cell subset [18, ...B cells induced the ...
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Y27, a novel derivative of 4 hydroxyquinoline 3 formamide, prevents the development of murine systemic lupus erythematosus like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice
... sing Treg cells in spleens of C57BL/6 mice immunized with MOG ...- cells were used as antigen-present- ing cells in co-culture with naïve MOG p35-55-specific T cells, ...
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CD4+ CD25+ T Cells Regulate Vaccine-Generated Primary and Memory CD8+ T-Cell Responses against Herpes Simplex Virus Type 1
... the T-cell ...⫹ T cells and boosted after 5 days with gB-DNA or ...⫹ T cells that produced IFN- ␥ upon restimulation in ...⫹ T cells was observed between depleted ...
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Original Article Regulatory function of TH17/Treg ratios in the children suffering from adenoidal hypertrophy with complications
... immune cells to involve in the immune responses ...of T cells is the core factor in the pathogenesis of ...in Treg cells and the pathogenesis are help- ful to reveal the impact of ...
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Review Article Resolution of inflammation in periodontitis: a review
... autologous Treg cells is relatively easy and generally includes a protocol of isolation, enrichment and re-infu- ...induce Treg cells in vivo, such as the injection of IL-2, have also been ...
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Medicinal herbs Fructus corni and Semen cuscutae suppress allograft rejection via distinct immune mechanisms
... graft-infiltrating cells were isolated and stained with anti-IL-12 (P40/70) and anti-CD11c or anti-IFNγ and anti-CD3 Abs one week ...graft-infiltrating T cells while SC plus FC further lowered their ...
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Recent advances in regulatory T cell therapy of autoimmunity, graft rejection and cancer
... Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a close relative of CD28, which is up regulated on T cells following ...on T lymphocytes binds to both CD80 and CD86 on ...
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Therapeutic application of T regulatory cells in composite tissue allotransplantation
... skin-resident T cells of donor origin are found to be associated with vas- cular, pilosebaceous, and epidermal sites of injury ...resident cells participating in immune surveil- lance due to multiple ...
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