T follicular helper
Critical role of IL-21 and T follicular helper cells in hypertension and vascular dysfunction
... in T and B cells develop blunted Ang II–induced hypertension, with the hypertensive response restored by adoptive transfer of T cells ...specific T cell sub- sets, most notably IL-17A–producing Th17 ...
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Role of T Follicular Helper cells in Multiple Sclerosis
... Multiple Sclerosis (MS) is a chronic, inflammatory and neurodegenerative disease which results from the destruction of myelin and associated collateral tissue damage within the central nervous system (CNS). MS is a ...
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Increased Circulating T Follicular Helper Cells in Iranian Children with Type I Diabetes
... years, T follicular helper (Tfh) cells have been recognized as a subpopulation of CD4 + T cells that required for germinal center formation, B cells differentiation and antibody ...+ T ...
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TGF β prevents T follicular helper cell accumulation and B cell autoreactivity
... T follicular helper (Tfh) cells contribute to the establishment of humoral immunity by controlling the delivery of helper signals to activated B cells; however, Tfh development must be ...
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CD57+ T-cells are a subpopulation of T-follicular helper cells in nodular lymphocyte predominant Hodgkin lymphoma
... of T-follicular helper (TFH) cells, PD-1 and ...+ T-cells are also positive for PD-1, whereas roughly half of the PD-1 + T-cells are CD57 + ...
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Expansion of HIV specific T follicular helper cells in chronic HIV infection
... CD4 T cells, which are required for the induction of high-affinity antibody responses and the formation of long-lived B cell ...CD4 T cells during HIV infection is therefore believed to impede the ...
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A critical role of T follicular helper cells in human mucosal anti-influenza response that can be enhanced by immunological adjuvant CpG-DNA.
... of T follicular helper cells in human mucosal anti-influenza response that can be enhanced by immunological adjuvant CpG-DNA, Antiviral Research (2016), doi: ...
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Searching for the origin of the enigmatic circulating T follicular helper cells
... T follicular helper (Tfh) cells in germinal centers of secondary lymphoid organs are pivotal for B and T cell interactions required for induction of humoral ...
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Understanding pathogenic and physiological T follicular helper cell formation
... CD80 expression on B cells regulates murine T follicular helper development, _germinal center B cell survival, and plasma cell generation.. B cells and TCR avidity determine distinct fun[r] ...
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Crucial Roles of Interleukin-7 in the Development of T Follicular Helper Cells and in the Induction of Humoral Immunity
... T follicular helper (Tfh) cells are specialized providers of cognate B cell help, which is important in promoting the induction of high-affinity antibody production in germinal centers ...of T ...
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Streptococcal superantigen‐induced expansion of human tonsil T cells leads to altered T follicular helper cell phenotype, B cell death and reduced immunoglobulin release
... Tonsil T cells proliferated in response to SpeA and demonstrated typical release of pro- inlammatory ...cultures, T follicular helper (Th) cells showed a reduction in C-X-C chemokine receptor ...
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Preservation of Peripheral T Follicular Helper Cell Function in HIV Controllers
... CD4 T cells, high levels of exhaustion marker expression, and other phenotypic lymphocyte abnormalities ...CD4 T cells express- ing combinations of functional markers present on germinal center (GC) ...
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T follicular helper cells in patients with acute schistosomiasis
... Background: The role of T follicular helper (Tfh) cells in schistosome infection is not fully defined. In a previous study, a higher frequency of circulating PD-1 + CXCR5 + CD4 + Tfh cells was ...
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HIV and T follicular helper cells: a dangerous relationship
... CD4 T cells that are required to help the B cell response, a high mutation rate that allows the rapid emergence of antigenic escape variants, and a structure of the envelope complex that makes conserved epitopes ...
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Distribution of distinct subsets of circulating T follicular helper cells in Kawasaki disease
... + T cell in KD, nonetheless, the results remain controver- sial ...CD4+ T cells, follicular T helper (Tfh) cells have been initially described in the germinal centers (GC) of secondary ...
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Enhanced IL 6/phosphorylated STAT3 signaling is related to the imbalance of circulating T follicular helper/T follicular regulatory cells in patients with rheumatoid arthritis
... + T cell lineages by the high expression of C-X-C chemokine receptor type 5 (CXCR5), programmed death-1 (PD-1), inducible co-stimulator (ICOS), CD40 ligand (CD40L), and secretion of interleukin-21 (IL-21) [7, ...+ ...
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T follicular helper cells in human efferent lymph retain lymphoid characteristics
... the follicular mantle of the B cell follicle, and follow- ing secondary challenge, some of these follicular mantle Tfh exit into the subcapsular sinus of the LNs (23), suggesting a potential opportunity for ...
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CD4 T follicular helper cell dynamics during SIV infection
... of the IL-6R subunits (data not shown), both of which support the expression profile of the IL-6R complex in TFH. Although with different kinetics (39), IL-6 induces phosphorylation of both STAT-1 and STAT-3 in T ...
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Expression of membrane bound CC chemokine ligand 20 on follicular T helper cells in T B cell conjugates
... The cellular expression of CCL20 and its putative function in the humoral immune response are still not understood. In comparison, its partner CCR6 on B cells has been characterized and its dynamic expression has been ...
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CD4 T Cell Help Is Limiting and Selective during the Primary B Cell Response to Influenza Virus Infection
... CD4 T cells as well as helper CD4 T cells and B ...CD8 T cell responses can result in viral clearance without a sup- porting antibody response (5, 6), the primary B cell response has been very ...
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