T-type calcium channel
The C elegans T type calcium channel CCA 1 boosts neuromuscular transmission
... the T-type calcium channel family found in vertebrates, plays a crucial role in the initiation of action potentials in the pharyngeal muscle of ...L-type calcium channels present ...
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Characterization of the molecular and electrophysiological properties of the T type calcium channel in human myometrium
... Panel B HVA/LVA expressing cells mean± SE n=12 per point current density vs step voltage from a holding potential of -50mV closed circle and 80mV closed square.. Mean current density at [r] ...
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Neuroprotective effects of blockers for T-type calcium channels
... intracellular calcium, which can lead to neuronal death in the ...various calcium channel blockers in pathological ...for T-type calcium channels, which forms a family of FDA ...
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Block of T-type calcium channels by protoxins I and II
... sodium channel blocker ProTx I tonically blocked native and transiently expressed T-type channels in the sub- to low micro molar range with at least a ten-fold selectivity for the ...
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Role of Nitrogen-Containing Natural Heterocyclic Compounds in Medical Science : A Mini Review
... Morpholinone cycles were found in many biologically active molecules and the reported properties include thrombin inhibitors [41], selective T-type calcium channel blockers [42], HIV-p[r] ...
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Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing
... addiction, T-type calcium channels are implicated in a number of other neurological dis- orders including in epileptic seizures [12–14, 46–48], anxiety [49–51], cognitive and memory impairments [52, ...
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GABAB receptors suppress burst-firing in reticular thalamic neurons
... affinity T-type calcium channel antagonists both prevents RTN burst-firing in acute brain slices and prevents absence seizures in vivo (Tringham et ...
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Pathogenic Cav3.2 channel mutation in a child with primary generalized epilepsy
... Cav3.2 T-type calcium channel. This channel is known to control neuronal ex- citability, plays a role in generating rebound burst-firing in thalamic reticular neurons and may contribute ...
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A T-type channel-calmodulin complex triggers αCaMKII activation
... Cav3.1-mediated calcium influx to account for the loss of FRET we substituted ...Cav3 calcium channel blockers TTA-P2 (20 μM) ...gers calcium influx through Cav3.1 calcium channels is ...
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Expression of calcium channel transcripts in the zebrafish heart: dominance of T type channels
... channel α -subunit genes was quantified in the atrium and ventricle of the zebrafish heart. Several studies have shown that expression of ion channel proteins in the heart is predominantly determined at the ...
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The intracellular loop between domains I and II of the B type calcium channel confers aspects of G protein sensitivity to the E type calcium channel
... We gratefully acknowledge financial support from the Wellcome Trust. We thank the following for generous gifts of cDNAs and reagents: Dr. T. Snutch (University of British Columbia, Vancouver, Canada), a1A, a1E, ...
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The L type calcium channel in the heart: the beat goes on
... (PP-1) removes phosphate at Ser16 in PLN and is upregulated in heart failure. Calstabin2 (FKB12.6) plays a role in stabilizing RyR2 in order to help maintain the channel in a closed state during diastole. RyR2 is ...
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T Time: A data repository of T cell and calcium release activated calcium channel activation imagery
... We also intend to increase the depth of the data available for each cell and time-lapse image. One such approach would be to attempt to predict the movement of T cells based on CRAC channel information as ...
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Role of Inositol 1, 4, 5-Triphosphate on Heart Rate in Isolated Heart Models of Wistar Rats
... the T-type calcium channels get activated and produce more ...The calcium ions entering the cell through this calcium channel activate calcium-induced calcium ...
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Analytical Models of Calcium Binding in a Calcium Channel
... the calcium channel can be calculated by algebra alone using the Fermi like distribution that takes into account ions of any size and water molecules and satisfies the saturation condition of ionic ...
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Calcium ions alter monoamine oxidase A activity
... Regulation of the flavoprotein monoamine oxidase A (MAO A) on the mitochondrial outer membrane is now being investigated for a role in cell signalling. In isolated mitochondria (1) and in cell lines (2), MAO A activity ...
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Clinical, genetic and expression studies of human CNS channelopathies
... wild type, two mutant + two wild type, three mutant + one wild type, four m utant and four wild ...complete channel contains three mutant and one wild type subunit, the wild type ...
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Effect of pH on trout blood vessels and gill vascular resistance
... Rainbow trout were killed by a blow to the head and vessels removed as above, or the gill arches isolated and cannulated as described elsewhere (Olson et al., 1986). Briefly, after the fish was stunned, the heart was ...
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SUMMARY Heat caused reduction in membrane protein thiol level and increased accumulation of thiobarbituric acid reactive substances in 72 hour old germinating tissues thereby reducing germination and early growth performances. Calcium chelator (EGTA), calcium channel blocker (LaCl
... performances. Calcium chelator (EGTA), calcium channel blocker (LaCl 3 ) and calmodulin inhibitor (trifluroperazine) aggravated the effects of heating and added calcium reversed them, implying ...
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A Calcium Conducting Channel Akin to a Calcium Pump
... The chances of seeing the ryanodine sensitive Ca2 + release channel would be expected to be very low since the junctional membrane containing this channel is only 4.5% of the whole sarco[r] ...
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