Tandem Duplications
Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia
... Background: Molecular characterisation of normal karyotype acute myeloid leukemia (NK-AML) allows prognostic stratification and potentially can alter treatment choices and pathways. Approximately 45–60% of patients with ...
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Next-generation sequencing of FLT3 internal tandem duplications for minimal residual disease monitoring in acute myeloid leukemia
... internal tandem duplications in FLT3 interferes with the auto-inhibitory function of the juxtamembrane domaine and constitutively activates the tyrosine kinase, leading to enhanced RAS, MAPK, and STAT5 ...
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Action of Repeat-Induced Point Mutation on Both Strands of a Duplex and on Tandem Duplications of Various Sizes in Neurospora
... sequence duplications are detected and altered efficiently during the sexual cycle by a process known as RIP (repeat-induced point ...of tandem repeats (from 16 to 935 bp in length) within the mtr gene to ...
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PROPERTIES AND EVOLUTIONARY POTENTIAL OF NEWLY INDUCED TANDEM DUPLICATIONS IN DROSOPHILA MELANOGASTER
... Tandem duplications appear to be predis- posed by reason of frequency of generation, crossover suppression and fitness effects to serve as the primary source of new genes.. HE[r] ...
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Effects of uvsX, uvsY and DNA topoisomerase on the formation of tandem duplications of the rII gene in bacteriophage T4.
... We conclude that T 4 DNA topoisomerase muta- tions affect the frequency of rZZ diploids, but that the effect is allele-specific and that T 4 DNA topoisomer- ase therefore[r] ...
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RADIATION INDUCED TANDEM DUPLICATIONS IN DROSOPHILA MELANOGASTER
... Tandem direct duplications have been detected in a variety of ways: (1 ) The mutant phenotype associated with the Bar, Hairy wing and the Beadex duplica- tions was the basis[r] ...
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Characteristics and Distribution of Large Tandem Duplications in Brook Stickleback (Culaea inconstans) Mitochondrial DNA
... (A) Enzymes with a single recognition site in the duplicated region produce a fragment pattern with incremental size differences among mtDNAs (arrow) containing additional copie[r] ...
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ASYMMETRICAL EXCHANGE IN ADJACENT TANDEM DUPLICATIONS
... I n other words, all of the additional B revertants produced by addition of the adjacent Bx duplication can be attributed solely to increased recombination caused by the ad[r] ...
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The effects of trans modifiers and tandem duplications on meiotic recombination in maize
... Control of homologous recombination between homologs and sister chromatids: DSBR occurs with either the homolog i.e., interhomolog recombination or sister chromatid i.e., interchromatid [r] ...
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THE GENETIC CONSTITUTION OF TANDEM DUPLICATIONS OF THE rII OF BACTERIOPHAGE T4D
... If the duplication terminates before the site of the mutation (Figure 6a), then rdP8 r + duplications produced by a single crossover will carry only the u m b o allele, whi[r] ...
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POLARIZED PAIRING AND RECOMBINATION IN TANDEM DUPLICATIONS OF THE WHITE GENE IN DROSOPHILA MELANOGASTER
... In Figure 2 are diagrammed the alternative pairing and crossover schemes in Dp-l/+ heterozygotes which lead to the recovery of the left and right halves of the duplicatio[r] ...
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Activation of mutated simian virus 40 enhancers by amplification of wild-type enhancer elements.
... Simian virus 40 revertants containing point mutations within the A and C dpml6 or B and C dpm26 enhancer elements contain tandem duplications that include the remaining wild-type element[r] ...
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Evolutionary dynamics of mitochondrial DNA duplications in parthenogenetic geckos, Heteronotia binoei.
... BROWN, 1987 Tandem duplications in animal mitochondrial DNAs: variation in incidence and gene content among lizards. BROWN, 1987 Evolution of animal mitochondrial DNA: re[r] ...
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Cytogenetic and FMS-Like Tyrosine Kinase 3 Mutation Analyses in Acute Promyelocytic Leukemia Patients
... Analysis of the FMS-like tyrosine kinase 3 internal tandem duplications and D835 mutations. Total RNA was extracted from Ficoll-Hypaque isolated leukemic blasts using RNeasy Kit (Qiagen, Valencia, CA, USA), ...
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MUTATION-SELECTION BALANCE IN MULTI-LOCUS SYSTEMS. I. DUPLICATE GENE ACTION
... Similarly, an extended model is more appropriate for loci that have undergone multiple tandem duplications over time, such as has occurred i n the globin-like clusters.. For example,[r] ...
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Gene and Genome Duplication in Acanthamoeba polyphaga Mimivirus
... trans duplications is observed at a sequence identity level of 25%, which characterizes the seg- mental gene duplication as a more ancient ...older tandem duplication ...cis duplications suggests a ...
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Macrophage-resistant murine simian virus 40 tumors express a retroviral type-specific gp70.
... Mouse cells transformed by wild-type SV40 virus often produce super T species with molecular weights higher than normal T antigen, caused by tandem duplications in the T-antigen gene dur[r] ...
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Recombination between chromosomal IS200 elements supports frequent duplication formation in Salmonella typhimurium.
... and eukaryotic chromosomes. We present evidence here that recombination between IS200 elements is a major contributor to formation of tandem duplications in Salmonella. Thus[r] ...
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Duplications and domain-generality
... The proposal below relies on the duplication of cognitive mechanisms. Before presenting my (cognitive) case studies, I will thus briefly outline the role of duplications in evolution. The importance of the ...
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DUPLICATIONS IN CAENORHABDITIS ELEGANS
... Hermaphrodites of this genotype with free-X duplications have invariably given frequencies of wild-type progeny lower than Mendelian expectation, apparently because of [r] ...
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