Tandem Mass
Development of Novel Liquid Chromatography-Electrospray Tandem Mass Spectrometry Approaches for the Structural Characterization of Brevetoxins Including in vitro Metabolites
... brevetoxin-3 in shellfish, a likely metabolite of brevetoxin-2. Plakas et al. [24, 25] exposed Eastern oysters (Crassostrea virginica) to brevetoxin-2, where the toxin was extensively metabolized. LC-MS fractions ...
124
A novel and rapid method to determine doxycycline in human plasma by liquid chromatography tandem mass spectrometry
... A simple, rapid, specific and sensitive liquid chromatography tandem mass spectrometric method has been developed and validated for the determination of doxycycline from the human plasma. Doxycycline is ...
8
A novel approach to denoising ion trap tandem mass spectra
... This study employs an algorithm called morphological reconstruction filter [31] to select the local maxima of a spectrum. The inputs of a morphological reconstruction filter are a "mask" signal which is the ...
10
Tandem mass spectrometry of biomolecules : applications and new methods
... in mass from 114 to 117 ...the mass of the tag remains constant at 145 ...same mass-to-charge in the mass ...low mass region of the tandem mass spectra where there is low ...
207
Algorithms for Glycan Structure Identification with Tandem Mass Spectrometry
... research, tandem mass spectrometry has also been widely used for the characterization of glycans and glycoproteins in complex biological ...the mass spectrometry analysis ...with tandem ...
109
Economic Evaluation of Tandem Mass Spectrometry Screening in California
... T HE California legislature authorized and funded a pilot tandem mass spectrometry (MS/MS) screening program, which was conducted from January 7, 2002, through June 13, 2003. During that period, 755 698 ...
9
TANDEM MASS SPECTROMETRIC INVESTIGATIONS ON SELENOCUMULENES AND NON-NATURAL AMINO ACID HYBRID PEPTIDES: DIFFERENTIATION OF ISOMERS OF THE PEPTIDES AND SOME AROMATIC SULFONIC ACIDS
... the tandem mass spectrometry of protonated peptides formed under electrospray ionization (ESI) and matrix assisted laser desorption ionization (MALDI) has been an established method for determining amino ...
20
An unsupervised machine learning method for assessing quality of tandem mass spectra
... of tandem mass spectra by supervised machine learning methods, which require labelled training datasets to train a ...worse, tandem mass spectrometers may produce differ- ent spectra for the ...
8
Quality Assessment of Tandem Mass Spectra by Using a Weighted K-Means
... a tandem mass spec- trometer provides an automated, high-throughput approach widely used to generate peptide (tandem) mass spectral data for the analysis of complex biological protein mixtures ...
8
Characterisation of phosphorylated nucleotides by collisional and electron-based tandem mass spectrometry
... from CID for this type of ion has led to studies aimed at gaining increased information from tandem mass spectrometry, including the use of electron-based techniques. ECD of adenosine triphosphate (ATP) and ...
9
Tandem mass spectrometry of non enzymatically glycated peptides and proteins
... experiments. Tandem mass spectrometry allowed assignment of the binding site to either the guanidine group at the side chain of the arginine residue of the N ...
385
Newborn screening using tandem mass spectrometry: A systematic review
... of tandem MS to neonatal ...using tandem MS, 16 the HTA Diagnostic Technologies & Screening Panel commissioned an updated review with economic ...
22
Economics of tandem mass spectrometry screening of neonatal inherited disorders
... Costs for all existing technologies were obtained from a previous HTA report (15) and revalorized to 2001 using the Health Services Cost Index. These values were used to obtain a probabilistic estimate of mean cost per ...
7
Algorithms for Peptide Identification from Mixture Tandem Mass Spectra
... accuracy mass spectrometry data will surely provide great help for the computational analysis, but currently based on the accuracy of the proteomics data we use, in this experiment, the error tolerance for ...
123
Economic Evaluation of Tandem Mass Spectrometry Newborn Screening in Australia
... Therefore, the following costs were in- cluded: (1) the cost of screening (including follow-up testing for both true-positive and false-positive cases); (2) the cost of treatment once co[r] ...
9
Immuno tandem mass spectrometry (iMALDI) assay for clinical diagnostics
... sensitivity in plasma (800 CFU) is lower than in PBS solution (ca. 10 CFU bacteria), may be due to incomplete digestion and to high levels of non-specific binding of other plasma proteins which can suppress the ion ...
84
Improved methods of tandem mass spectrometry for proteomics applications in a quadrupole ion trap mass spectrometer
... of mass analysis (MSn) which allows product ions to be activated after they have been ...activation mass of m/z 140 was specified along with an isolation window of 100 Da (the maximum ...
182
Improvements in electrospray ionization source design and advances in tandem mass spectrometry
... a mass-to-charge dependence on the efficiency of ion extraction from the collision hexapole and ion flight times to the ICR ...Smaller mass-to-charge ions exert a greater space charge effect on larger ...
206
Cost-Benefit Analysis of Universal Tandem Mass Spectrometry for Newborn Screening
... total mass spectrometry screening programs show that rates of death and morbidity are higher than our conservative estimates of 3% to 7%, such findings would substantially decrease the costs of QALY and more ...
8
Tandem mass spectrometry of polymeric materials
... High and low energy collision induced dissociation eID spectra were obtained by means of a four sector mass spectrometer and a tandem quadrupole instrument respectively.. Surface induced[r] ...
337