tar-DNA binding protein
Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C
... Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by the occurrence of visceral and neurological symptoms. At present, the molecular mechanisms causing neurodegeneration in this disease are ...
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In silico mutation analysis of TAR DNA binding protein-43 causing fronto temporal lobar degeneration
... between TAR DNA binding protein 43 and its substrate (RNA), we used the program PatchDock for docking the native and mutant TAR DNA binding protein 43 with RNA to ...
9
Amyotrophic lateral sclerosis mutant vesicle associated membrane protein associated protein B transgenic mice develop TAR DNA binding protein 43 pathology
... containing TAR-DNA-binding protein-43 (TDP-43) within motor neurons are the hallmark pathology of sporadic amyotrophic lateral sclerosis ...nuclear protein and the mechanisms by which ...
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Pedigree with frontotemporal lobar degeneration – motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9
... The TAR DNA binding protein (TDP-43) is a nuclear protein implicated in exon splicing and transcrip- tion regulation, [6] and was recently identified as a major protein component ...
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Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway
... of TAR DNA-binding protein 43 (TDP-43), a nuclear DNA/RNA-binding protein involved in RNA metabolism, is a pathological hallmark of amyotrophic lateral sclerosis ...C ...
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Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments
... of TAR DNA binding protein-43 (TDP-43) are the defining histopathological feature of several neurodegenerative diseases collectively referred to as TDP-43 ...
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Virus mediated delivery of antibody targeting TAR DNA binding protein 43 mitigates associated neuropathology
... matched nontransgenic mice (n = 3 per group) (Supplemental Fig- ure 6B) and analyzed brain samples 24 hours after LPS injection. Quantification of ionized calcium–binding adaptor molecule 1 (Iba1) staining ...
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Disease-modifying effects of metabolic perturbations in ALS/FTLD
... pathological protein aggregates that contain a number of proteins, most notably TAR DNA binding protein 43 kDa ...and TAR DNA binding protein of 43 kDA ...
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Human T-Cell Lymphotropic Virus Type 1 Nucleocapsid Protein-Induced Structural Changes in Transactivation Response DNA Hairpin Measured by Single-Molecule Fluorescence Resonance Energy Transfer
... nucleocapsid protein (NC) chaperone activity compared to that of the human immu- nodeficiency virus type 1 (HIV-1) NC ...CCHC binding motif similar to HIV-1 ...chaperone protein that facilitates ...
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Inhibition of HIV derived lentiviral production by TAR RNA binding domain of TAT protein
... plasmid DNA pLenti-EGFP-TRIP together with pack- aging plasmids, pLP1, pLP2, and pVSV-G, (Invitrogen, San Diego, CA) using the calcium phosphate precipitation method according to manufacturer's description ...
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Specific repression of Tax trans-activation by TAR RNA-binding protein TRBP.
... of DNA in 293T cells by the calcium phosphate method, using 1 to 5 mg of expression ...with protein A-Sepharose if cells were transfected with Ig-TRBP expression ...48C. Protein A-Sepharose beads ...
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Evidence for DNA Hairpin Recognition by Zta at the Epstein-Barr Virus Origin of Lytic Replication
... imperfect DNA hairpin formed within the top strand of a critical element within the lytic origin ...of binding (from the experiment for which results are shown in panel B) and EBV/GAPDH DNA copy ...
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Mechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124.
... (DNA binding buffer) for 50 min on ...of protein A-Sepharose beads in NET buffer (50 mM Tris z HCl [pH ...in DNA binding buffer before addition to the T antigen-DNA ...
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Human herpesvirus 6B origin-binding protein: DNA-binding domain and consensus binding sequence.
... a DNA-binding assay that the human herpesvirus 6B (HHV-6B) replication origin has a structure similar to those of alphaherpesviruses, although the HHV-6B and herpes simplex virus type 1 (HSV-1) ...
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Dominant mutations in mtDNA maintenance gene SSBP1 cause optic atrophy and foveopathy
... Clinical phenotype of patients with SSBP1 mutations. The pre- dominant clinical symptom exhibited by the present cohort of patients with SSBP1 mutations is an optic atrophy. We collect- ed DNA samples from 36 ...
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Comparative genomics of rumen methanogens : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand
... methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase (AcsE), acetyl CoA synthetase (Acs), phosphoglucomutase (Pgm), phosphoglucose isomerase (Pgi), fructose-1,6-bisphosphatatase (Fbp), ...
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Purification of the herpes simplex virus type 1 65-kilodalton DNA-binding protein: properties of the protein and evidence of its association with the virus-encoded DNA polymerase.
... 8 Purification of the Herpes Simplex Virus Type 1 65-Kilodalton DNA-Binding Protein: Properties of the Protein and Evidence of Its Association with the Virus-Encoded DNA Polymerase MICHA[r] ...
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Tumor necrosis factor alpha eliminates binding of NF Y and an octamer binding protein to the lipoprotein lipase promoter in 3T3 L1 adipocytes
... a DNA region downstream of -180 bp confers the TNF alpha ...LPL DNA-protein interactions after TNF alpha treatment, including the binding of NF-Y to the CCAAT box and a protein to the ...
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DNA-binding protein associated with herpes simplex virus DNA polymerase.
... Again, the protein was eluted by a gradient of 0 to 0.4 M KCI, and the fractions indicated by the solid horizontal line which were found to contain ICSP 34, 35 were pooled, dialyzed, and[r] ...
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Thrombin activates a Y box–binding protein (DNA binding protein B) in endothelial cells
... stranded DNA, which is consistent with the action of other Y-box proteins (21, 22, ...single-stranded DNA regions that are thought to be important in the regulation of gene expression (for review, see ...
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