target of rapamycin complex
Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression
... The precise mechanisms involved in the regulation of hypothalamic peptide expression and release remain to be fully determined. Recent studies have indicated a key role for the class 1A phosphoinositide-3-kinases ...
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Endoplasmic reticulum stress-induced apoptosis in intestinal epithelial cells: a feed-back regulation by mechanistic target of rapamycin complex 1 (mTORC1)
... mechanistic target of rapamycin (mTOR) is a master regulator of various cellular processes including cell proliferation, survival, metabolism, autophagy, and the synthesis of proteins and lipids ...mTOR, ...
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NR6A1 regulates lipid metabolism through mammalian target of rapamycin complex 1 in HepG2 cells
... The experiments have shown that INSR expression can be directly targeted by several miRNAs, such as miR-424- 5p, miR-15b, miR-1271, miR-195, miR-497 and miR-96 in HepG2 or other type cells [36 – 38]. In addition, gene ...
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West Nile Virus-Induced Activation of Mammalian Target of Rapamycin Complex 1 Supports Viral Growth and Viral Protein Expression
... We have shown for the first time in a flavivirus model of viral infection that West Nile virus infection of serum-starved mam- malian cells activates mTOR complex 1 in support of viral growth and viral protein ...
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Saccharomyces cerevisiae TORC1 Controls Histone Acetylation by Signaling Through the Sit4/PP6 Phosphatase to Regulate Sirtuin Deacetylase Nuclear Accumulation
... that target of rapamycin complex 1 (TORC1) signaling, which is activated by nitrogen metabolism and amino acid availability, promotes site-speci fi c acetylation of histone H3 and H4 N-terminal tails ...
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Metabolism, migration and memory in cytotoxic T cells
... mammalian target of rapamycin complex 1 (mTORC1) through the phosphorylation of the GTPase-activating protein TSC2 (tuberous sclerosis complex 1) at position ...TSC1–TSC2 complex and ...
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Post prandial regulation of hepatic glucokinase and lipogenesis requires the activation of TORC1 signalling in rainbow trout (Oncorhynchus mykiss)
... of rapamycin complex 1) signalling in the regulation of post-prandial hepatic lipid and glucose metabolism-related gene expression in trout, we employed intraperitoneal administration of rapamycin to ...
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Regulation of bone formation by baicalein via the mTORC1 pathway
... mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, and induced expression of osteoblast differentiation markers, ie, osteocalcin, osterix, collagen Iα1, and runt-related ...
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Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
... dominant rapamycin-resistance phenotype of the mutant alleles, and sequenced (Cafferkey et ...by rapamycin treatment, suggesting that TOR1 and TOR2 are indeed the targets of FKBP–rapamycin and that ...
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Regulation of signalling circuitry downstream of mTORC1(mammalian target of Rapamycin)
... 1438 | P a g e kinases were first identifed as cellular counterparts of the transforming viral oncogene v-akt [84]. Akt was demonstrated to inhibit apoptosis in several cell types, at least in part, by phosphorylating ...
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Mammalian target of rapamycin signaling in diabetic cardiovascular disease
... Unlike mTORC1, mTORC2 does not have Raptor as a component but contains Rictor (Figure 1). However, mTORC2 shares several common components with mTORC1, such as mTOR, mLST8, and Deptor. mTORC2 also associates with the ...
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The mechanistic target for rapamycin pathway is related to the phosphorylation score for estrogen receptor α in human breast tumors in vivo
... Previous reports have suggested that estrogen can regulate the mTOR pathway. Activation of mTOR was most often determined by demonstrating activation of p70S6K, a downstream target of mTOR, although other markers ...
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MiR 21: an environmental driver of malignant melanoma?
... The versatility of miRs as molecular tools inspires the design of novel strategies for the treatment of malignant melanoma [247]. As suggested for glioblastoma and ovar- ian carcinoma [248, 249], anti-miR-21 treatment ...
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Original Article Puerarin modulates autophagy to ameliorate cerebral ischemia/reperfusion injury through JNK signaling pathway
... lin1/Bcl2 complex [14], adenosine monophos- phate-activated protein kinase (AMPK)-mam- malian target of rapamycin (mTOR) [15, 16], and the c-Jun N-terminal kinase (JNK) signaling pathway [17] could ...
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Rapamycin Exerts Antifungal Activity In Vitro and In Vivo against Mucor circinelloides via FKBP12-Dependent Inhibition of Tor
... immunosuppressive rapamycin analogs with potent antifungal ef- fects (14, 15, ...Indeed, rapamycin encapsulated within PEG-DSPE (polyethylene glycol– ...
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Loss of Ypk1 Function Causes Rapamycin Sensitivity, Inhibition of Translation Initiation and Synthetic Lethality in 14-3-3-Deficient Yeast
... to rapamycin, similar to 14-3-3 mutations and other mutations affecting the TOR signaling pathway in ...with rapamycin, loss of Ypk function disrupted translation, at least in part by causing depletion of ...
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Aberrant expression of microRNA-99a and its target gene mTOR associated with malignant progression and poor prognosis in patients with osteosarcoma
... Background: The mammalian target of rapamycin (mTOR) has been reported to act as a target gene of microRNA (miR)-99a in various cancer cells and identified as an independe[r] ...
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Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging
... FIGURE 1. mTOR complex 1 regulation by and binding to transiently expressed wild-type and mutant Rag heterodimers. A and B, binding of endoge- nous (A) and recombinant (B) mTORC1 by various RagB/C dimers or Rheb ...
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Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells
... mammalian target of rapamycin (mTOR) is a protein kinase that regulates protein translation, cell growth, and ...apoptosis. Rapamycin (RPM), a specific inhibitor of mTOR, exhibits potent and broad in ...
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Drosophila Target of Rapamycin Kinase Functions as a Multimer
... (K im et al. 2002), consistent with the widely distributed contacts reported for other HEAT-associated proteins (G roves et al. 1999). The TOR kinase domain, of the phosphoinositol kinase-related kinase (PIKK) family, ...
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