Targeted Agents
Tumor Resistance to Molecularly Targeted Agents
... molecularly targeted drug era has led to meaningful increases in survival for some specific cancer patients enrolled in clinical ...these agents has been demonstrated as larger numbers of patients are ...
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<p>Current Molecular Targeted Agents for Advanced Gastric Cancer</p>
... molecularly targeted agents that inhibit speci fi c oncogenic signal pathways has promoted the personalization of cancer therapeutic treat- ment and has greatly improved the outcomes of ...molecular ...
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Impact of systemic targeted agents on the clinical outcomes of patients with brain metastases
... by targeted agent ...receiving targeted agents if they received a targeted agent either concurrently with SRS or within 1 month after completion of ...between targeted agent status were ...
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Personalizing Therapy with Targeted Agents in Non-Small Cell Lung Cancer
... no previous EGFR TKI therapy received BIBW2992 as single agent [59]. Overall RR was 60%, with a promising PFS of 14 months. This drug has also shown activity in patients whose tumors harbored less common EGFR mutations ...
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Development of Molecularly Targeted Agents and Immunotherapies in Glioblastoma: A Personalized Approach.
... immunotherapy agents in other cancer subtypes, together with the considerable medical need in the absence of approved targeted therapies in GBM, has led to the questioning of the previously-held belief that ...
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Development of molecularly targeted agents and immunotherapies in small cell lung cancer.
... Multiple putative predictive biomarkers of platinum sensitivity and clinical outcomes in SCLC have been investigated [3, 64]. Karachaliou and colleagues identified a gene expression signature from 184 patients with SCLC ...
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Combining Molecularly Targeted Agents: Is More Always Better?
... molecularly targeted agents against key signaling pathways to overcome treatment resistance observed with single agent therapies ...such targeted combinations, ...of targeted combinations, ...
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Targeting targeted agents: open issues for clinical trial design
... Molecularly targeted agents for the treatment of solid tumors had entered the market in the last 5 years, with a great impact upon both the scientific community and the ...new targeted agents, ...
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Efficacy and toxicities of adding molecular targeted agents to first-line chemotherapy in the treatment of advanced biliary tract cancer: a systematic review and meta-analysis
... receptor agents to first-line chemotherapy in advanced BTC offers an improved ORR and PFS, but not for ...molecular targeted agents, meta- ...
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Combining molecular targeted agents with radiation therapy for malignant gliomas
... The negative results reported in the majority of published clinical studies may be explained, at least in part, by this single-target approach, which may be somewhat limited by such factors as tumor heterogeneity and ...
17
Novel targeted agents for gastric cancer
... decade, targeted therapies have signifi- cantly impacted the treatment strategy of many common malignancies, including breast, colorectal, and lung can- ...encouraging targeted treatments for GC than for ...
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Targeted agents for the treatment of metastatic melanoma
... novel targeted agents is likely due, in part, to the cross talk that occurs between the pathways required for melanoma development and ...of targeted agents will hopefully lead to improved ...
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Fluorescence-guided cancer surgery : clinical translation of tumor-targeted agents
... tems for intraoperative use was assessed. The goal of our experiment was not to quantify performance of an individual imaging systems, but to demonstrate how to compare different imaging systems and predict clinical ...
84
Predictive and prognostic biomarkers of targeted agents and modern immunotherapy in renal cell carcinoma
... immunotherapy agents, the identi- fi cation of predictive and prognostic biomarkers has so far shown some promising preliminary results but remains at a very early and immature ...
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Long-term overall survival and prognostic score predicting survival: the IMPACT study in precision medicine
... gational agents against various targets, drugs approved by the FDA for a specific alteration outside their labeled indi- cation, or combinations of targeted agents with cytotoxics, cytokines, ...
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New trends for overcoming ABCG2/BCRP-mediated resistance to cancer therapies
... cancer agents that are ABCG2 ...and targeted agents that are substrates for the ABCG2 transporter, a growing body of work links ABCG2 to multiple photodynamic therapy (PDT) agents, and there ...
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Rationale for targeted therapies and potential role of pazopanib in advanced renal cell carcinoma
... of targeted agents, such as the tyrosine kinase inhibitors (TKIs), which have become the standard of care in managing advanced clear cell ...these agents to receive Food and Drug Administration ...
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The war on cancer: have we won the battle but lost the war?
... molecularly targeted agents and found that, while the dose used in phase I trials was overall safe, the section was based on diverse practices and a wide variety of toxicologic parameters without any ...
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<p>Treating advanced breast cancer with metronomic chemotherapy: what is known, what is new and what is the future?</p>
... with targeted agents (especially immune checkpoint inhibitors), and role in the adjuvant setting for patients who did not achieve pCR with neoadjuvant treat- ment, or who have low TILs in the residual ...
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The effect of anti-VEGF drugs (bevacizumab and aflibercept) on the survival of patients with metastatic colorectal cancer (mCRC)
... peutic agents, molecularly targeted agents began to play an important role in the treatment of advanced solid ...molecularly targeted agents have been approved for treatment of patients ...
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