Targeted immunotherapy
Impact of host immunity on HTLV 1 pathogenesis: potential of Tax targeted immunotherapy against ATL
... In ATL patients, half of the cases retain the ability to express Tax in ATL cells, while the other half lose this ability [20]. Therefore, the therapeutic effects of Tax- targeted immunotherapy are expected ...
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A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells
... Further analyses and visualisation of the in vivo gene expression data confirmed perturbations in the NRF2 network and down regulation of some NRF2 target genes, especially genes associated with antioxidant responses ...
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A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells
... Further analyses and visualisation of the in vivo gene expression data confirmed perturbations in the NRF2 network and down regulation of some NRF2 target genes, especially genes associated with antioxidant responses ...
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Folate targeted immunotherapy effectively treats established adjuvant and collagen induced arthritis
... Comparison of the effects of various arthritis therapies on disease severity in rats with established adjuvant-induced arthritic (AIA) Comparison of the effects of various arthritis therapies on disease severity in rats ...
10
The application of the fibroblast activation protein α-targeted immunotherapy strategy
... of immunotherapy involving T cells targeting cancer cells, an agent targeting FAP α-expressing cells might increase therapeutic efficacy against both solid tumors and metastatic cells ...combined ...
11
Mucocutaneous candidiasis: the IL 17 pathway and implications for targeted immunotherapy
... Use of biologic therapy to treat autoimmune diseases and diseases of abnormal inflammation has been on the rise. Some adverse effects of these medications are known based on vigorous clinical trials, but others can be ...
9
CD200 in CNS tumor-induced immunosuppression: the role for CD200 pathway blockade in targeted immunotherapy
... tumor immunotherapy and the use of antagonist peptides as effective agents to block the suppressive effects of ...enhance immunotherapy not only for gli- oma, but for breast carcinoma as ...
10
Treatment of prostate cancer: therapeutic potential of targeted immunotherapy with APC8015
... Mechanisms by which tumor cells escape from the body’s immune responses are several and include: (1) down regulation of the immune response by tumor cells themselves or by factors tha[r] ...
8
Oligomeric tau-targeted immunotherapy in Tg4510 mice
... models of Alzheimer’s pathology (largely anti-Aβ studies) successfully administered antibodies via intraperitoneal in- jections [32, 38–40]. Other potential explanations for the discrepancies could be that the Tg4510 ...
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Update on benefit of immunotherapy and targeted therapy in melanoma: the changing landscape
... in targeted agents and immunotherapies that have improved the management and treatment of patients with advanced ...of targeted immunotherapy and the role of predictive biomarkers in better selection ...
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Bridging infectious disease vaccines with cancer immunotherapy: a role for targeted RNA based immunotherapeutics
... Future vaccine strategies will build on the success of pre- vious advances while ameliorating the limitations of the immunogenic but highly degradable naked RNA vaccines, and the limitations of the protected but ...
7
Response to targeted therapy or chemotherapy following immunotherapy in patients with gastrointestinal cancers - a case series
... series in NSCLC with patients receiving chemotherapy post-ICI showing unexpectedly high response rates (RR) [3] [4, 5]. A patient with malignant melanoma, a cancer traditionally considered chemotherapy resistant, was ...
6
Effect of targeted ovarian cancer immunotherapy using ovarian cancer stem cell vaccine
... of immunotherapy to existing therapeutic options could lead to a great improvement in the outcome of ovarian cancer immune tolerance, especially when tar- geting CSCs ...
10
Multiple Chemotherapy-Based Combination Therapy Strategies for Advanced Lung Cancer Patients: A Systematic Review and Network Meta-Analysis
... with targeted therapy was superior to chemotherapy alone in terms of OS, PFS or ORR, but the incidence of adverse reactions did increase (Figure ...multiple targeted drugs aims at circumventing drug ...
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Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy
... patients, immunotherapy now offers the hope of durable remissions and even lifelong cures in a setting in which therapeutic success was previously defined by a few months of extended ...
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Does VEGF targeted active immunotherapy induce complete abrogation of platelet VEGF levels?
... active immunotherapy is able to reduce platelet VEGF levels; however it is unknown whether this effect leads to a decrease in VEGF below the levels that can be observed in healthy ...
5
Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies
... First, our analysis was based solely on alterations iden- tified from DNA sequencing. It is likely that some of the alterations do not create neoantigens because the gene (or variant allele) is not ...
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Formulation and Characterization of Orally Dissolving Thin Films containing the German cockroach Blatella germanica (Bla g 2) Allergen
... 41%. Immunotherapy has been shown to be an effective treatment for other allergies that contribute to asthma, but several factors have limited its use for cockroach ...sublingual immunotherapy (SLIT) ...
6
Antigen-based immunotherapy for autoimmune disease: current status
... allergen immunotherapy elicits a shift in the immunological response to an allergen from a Th2- dominated response to a Th1-dominated response with an associated decrease in allergen-specific IgE and increase in ...
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Ultrasound-Guided Mechatronic System for Targeted Delivery of Cell-Based Cancer Vaccine Immunotherapy in Preclinical Models
... a targeted injection, a mouse is typically anesthetised using isoflurane; this requires constant monitoring of dosage, body temperature, and heart rate to maintain sufficient anesthesia without ...
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