Targeted molecular imaging agents
Solid Phase Synthesis of Modular Peptide-based Targeted Molecular Imaging Agents
... create targeted molecular imaging agents (TMIAs) from the peptide targeting groups that are synthesizing, we will use makes use of the puzzle piece approach developed in our ...as ...
94
Modular Synthesis of Targeted Molecular Imaging Agents for MRI, PET, and PET-MRI of Cancer
... improving molecular imaging methods is the use of targeted molecular imaging agents ...the imaging agent to the cancerous cells, the imaging agent will collect more ...
109
The Development, Use, and Optimization of Sortase-Tag Expressed Protein Ligation
... Molecular imaging is an emerging field that seeks to combine the mechanistic detail of biochemical assays with the the broad phenotypic data obtained from non-invasive medical ...of molecular ...
189
An In Vivo Evaluation of the Effect of Repeated Administration and Clearance of Targeted Contrast Agents on Molecular Imaging Signal Enhancement
... ultrasound molecular imaging studies where endothelial binding sites become occupied with adherent bubbles or bubble ...of targeted agents has on successive ...lecular imaging. ...
6
New strategy for monitoring targeted therapy: molecular imaging
... hypoxia imaging has become applicable by using radiolabeled hypoxia agents together with noninvasive imaging techniques such as PET or single photon emission computed ...
11
Diagnostic and intraoperative targeted molecular imaging for pancreatic cancer
... For molecular imaging to be of an additional value in detection and treatment of pancreatic cancer, a highly specific imaging signal is ...For imaging purposes, the ideal target is a ...
325
High Precision Imaging of Microscopic Spread of Glioblastoma with a Targeted Ultrasensitive SERRS Molecular Imaging Probe
... resonance imaging (MRI) using FLAIR or diffusion-weighted sequences could enable imaging of microscopic tumor infiltrations [11, ...contrast agents [16]. In addition, small molecule Gd-agents ...
10
Activatable Fluorophores for the Molecular Imaging of Cytosolic Phospholipase A2 in Breast Cancer
... fluorescence imaging agents targeted towards ...fluorophores targeted towards cPLA2 and evaluate their use for the molecular imaging of breast cancer in order to determine their ...
146
<p>A new strategy for accurate targeted diagnosis and treatment of cutaneous malignant melanoma: dual-mode phase-change lipid nanodroplets as ultrasound contrast agents</p>
... Recently, molecular targeting imaging technologies have been developed, such as MRI, SPECT and PET, 7 and these imaging modalities are expected to bring about precise detection of small primary ...
15
Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy
... multifunctional agents to integrate tumor targeting, imaging and ...and imaging intracellular pH gradient and ...tumor targeted dual-modal imaging via near-infrared fluorescence (NIRF) ...
14
Disclosing the CXCR4 Expression in Lymphoproliferative Diseases by Targeted Molecular Imaging
... anti-HIV agents and safe agents for the mobilization of HSPC for au- tologous transplantation in patients with hematolog- ical malignancies such as lymphoma and multiple ...
13
The Development of Metal-Organic Compounds for Use as Molecular Imaging Agents
... using molecular imaging offers a more accurate and non-invasive method of diagnosis by targeting receptors overexpressed on cancer ...cancer imaging probes, for example, can target the overexpressed ...
201
Imaging Key Biomarkers of Tumor Angiogenesis
... Currently, targeted tracers for molecular imag- ing of integrins and VEGF receptors in different mo- dalities receptors are reasonable well-developed and some RGD-based tracers are already in clinical ...
14
uPAR-targeted Optical Imaging Contrasts as Theranostic Agents for Tumor Margin Detection
... optical imaging of tumor margins, it is also critical that the selected cell surface target should be highly expressed in the tumor ...for imaging tumor margins ...
13
Research Paper Nanoparticles in cancer therapy
... Previous works at the University of Nigeria, Nsukka and papers on Nanosciences and Nanotechnology were reported elsewhere (Obikwelu, 2008; Obayi et al., 2008). Taeghwan Hyeon of Seoul National University (Science ...
10
Targeted delivery of reduced graphene oxide nanosheets using multifunctional ultrasound nanobubbles for visualization and enhanced photothermal therapy
... 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC); 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)-2000] (DSPE-PEG2000); and 1,2- distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl ...
14
The war on cancer: have we won the battle but lost the war?
... new agents into Phase I and II trials and academic centers cannot match that ...of molecular targeted therapy for cancer, partnerships between industry and academia that takes advantage of their ...
7
Gastrin-releasing Peptide Receptor Imaging in Breast Cancer Using the Receptor Antagonist 68Ga-RM2 And PET
... different molecular subtypes of BC include luminal A, luminal B, luminal B-like, Her2-neu positive and triple negative ...novel molecular diagnostic biomarkers may be helpful to optimize subtype-specific ...
10
Efficacy and toxicities of adding molecular targeted agents to first-line chemotherapy in the treatment of advanced biliary tract cancer: a systematic review and meta-analysis
... BTCs are considered to follow the sequence of dysplasia followed by hyperplasia of the bile duct epithelium. To date, several molecular pathways, such as EGFR and VEGF signal pathway, have been suggested to be ...
6
The Development of Metal Complexes as Components of Fluorescent and Nuclear Imaging Probes
... The cellular permeability of the three Re(I) complexes was evaluated in OVCAR-8 ovarian cancer cells by confocal fluorescence microscopy (Figure 3.4, see Appendix B for DIC images). The cells were incubated with the ...
187