TCF7L2 gene
Original Article Association of rs7903146 and rs7085532 polymorphisms in TCF7L2 gene with type 2 diabetes mellitus in a Chinese Uygur population
... Blood samples were collected from the study participants with informed consent after over- night fasting. Genomic DNA was extracted from blood samples using the DNA extraction Kit (Beijing Biotech Company Limited, ...
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Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK resident South Asian population
... the TCF7L2 gene are strongly associated with type 2 dia- betes in populations of South Asian origin, with similar effect sizes to those seen in white Caucasian ...
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Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Juana Koslay, San Luis Province, Argentina
... OALibJ | DOI:10.4236/oalib.1101419 7 March 2015 | Volume 2 | e1419 WNT activity is important for lipid and glucose metabolism, pancreatic beta cell proliferation and function and for production of incretin hormone GLP-1 ...
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Association of TCF7L2 Gene with Familial Combined Hyperlipidemia in Diabetes Mellitus Type 2 Females Iraqi Patients
... {TCF7L2} gene are scanned to be powerfully related to diabetes mellitus type 2 (DM2) in female Iraqi ...of TCF7L2 gene polymorphisms with DM2 in a very female populace of ...that TCF7L2 ...
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The Association of rs7903146(C/T) and rs12255372(G/T) Polymorphisms of the TCF7L2 gene with Type 2 Diabetes Mellitus in Chennai Suburban Population
... of TCF7L2 gene is not known, it was postulated that TCF7L2 gene polymorphic variants have effect on proinsulin processing in the beta cells of pancreas that may predispose to type 2 diabetes ...
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Original Article Association of rs3814570 and rs7094463 polymorphisms in TCF7L2 gene with susceptibility to type 2 diabetes mellitus in a Chinese Uygur population
... that TCF7L2 gene variants seem to confer susceptibility to T2DM indirectly by altering GLP-1 levels ...the TCF7L2 gene is an important factor regulating insulin secretion, which could explain ...
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IMPACT OF THE TRANSCRIPTION FACTOR 7 LIKE2 (TCF7L2) GENE POLYMORPHISMS ON THE RISK OF POLYCYSTIC OVARY SYNDROME IN IRAQI PATIENTS
... of TCF7L2 gene polymorphisms (rs7903146) with the incidence of PCOS and diabetic PCOS in Iraqi patients (women) was evaluated in this ...the TCF7L2 gene was carried out by using PCR-RFLP ...
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Identifying Variant Positions of TCF7L2 Gene Related to T2DM
... ABSTRACT: Type2Diabetes Mellitus (T2DM) is associated with impaired insulin secretion. It is the most leading public health problem around the globe, particularly the developing nations in South Asian countries which ...
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Association between the IVS4G > T mutation in the TCF7L2 gene and susceptibility to diabetes in cystic fibrosis patients
... CFTR gene was performed in the laboratory of Table 4 Association IVS4G > T mutation in TCF7L2 gene after genotypic groupings, distributed by genotype for the mutation in the CFTR gene ...
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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
... in TCF7L2 increase gene expression in human ...in TCF7L2 are in noncoding regions, we hypoth- esized that one potential mechanism by which they could exert the observed effects is by influencing ...
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TCF7L2 correlation in both insulin secretion and postprandial insulin sensitivity
... the TCF7L2 gene in indi- viduals with T2DM was associated with increased post- prandial secretion of insulin, proinsulin, and C-peptide when compared with the absence of the ...
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Association between the TCF7L2 rs12255372 (G/T) gene polymorphism and type 2 diabetes mellitus in a Cameroonian population: a pilot study
... This study, with a caution on sample size showed an association between the rs12255372 (G/T) polymorphism of the TCF7L2 gene and type 2 Diabetes in a Cameroonian population. The Hardy-Weinberg equilibrium ...
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Ramanathan
... Figure 1A, Figure 2B represent the PCR amplified regions pertaining to a 318 bp product of the TCF7L2 gene that encompasses the single nucleotide change for rs7903146 (C>T), and a 352 bp for the ...
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Genetic associations between Transcription Factor 7 Like 2 rs7903146 polymorphism and type 2 diabetes mellitus: a meta-analysis of 115,809 subjects
... (TCF7L2) gene encodes T cell transcription factor 4, a transcription factor of the Wnt/β-catenin signaling pathway that is vital for embryogenesis of the pancreas islet and regulation of blood glucose [5, ...
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Reduction in Tcf7l2 Expression Decreases Diabetic Susceptibility in Mice
... of TCF7L2 is decreased in diabetic patients as their body mass index (BMI) increase ...decreased Tcf7l2 expres- sion in the liver is simply protective as a feedback mechanism during metabolic ...thermore, ...
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Hydrogen Gas-An Initiative for Coherent Use Of Renewable Energy
... considered gene microarray data where various attributes are given for each ...prove TCF7L2 is highly related to T2DM we segregated data into two groups where first group contains TCF7L2 gene, ...
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Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study
... the TCF7L2 gene was analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method with the following primers: forward 5′-AAG AGA AGA TTC TTC TTT AAA TGG TG-3′ and ...
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Effects of the diabetes linked TCF7L2polymorphism in a representative older population
... Type 2 diabetes mellitus is an important disabling condi- tion[1], and its prevalence is increasing. Type 2 diabetes mellitus is generally understood to be a metabolic disor- der defined by hyperglycemia and insulin ...
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Prevalence of the rs7903146C>T polymorphism in <em>TCF7L2</em> gene for prediction of type 2 diabetes risk among Iranians of different ethnicities
... Results: The homozygous wild-type (C/C), heterozygous (C/T), and homozygous (T/T) allelic frequencies of rs7903146 (C.T) in the TCF7L2 gene were 29% (extensive metabolizers), 66.34% (intermediate ...
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Effect of TCF7L2 polymorphism on pancreatic hormones after exenatide in type 2 diabetes
... linking TCF7L2 gene polymor- phism to T2DM may lie in two of the major mechanisms of the pathophysiology of disease, namely, defects in GLP-1 mediated insulin secretion at a pancreatic level, and GLP-1 ...
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