Tcr signaling
ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma
... To further elucidate the essential role of ITK in the pathogenesis of AITL, several malignant T-cell leuke- mia or lymphoma cell lines (Jurkat, Hut-78, Hut-102, Karpas-299 and H9) were selected for in vitro functional ...
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Molecular alterations in the TCR signaling pathway in patients with aplastic anemia
... other signaling mole- cules of TCR signaling such as CD3γ, CD3δ, CD3ε, and ZAP-70 [32, 33] also have similar change trend in AA, it is needed further investigation, and it is suggested to ...
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Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia
... mediates signaling through ZAP-70, FcεRIg mediates signaling by associat- ing with the phosphorylated protein kinase Syk ...classical TCR/CD3ε/CD3ζ/Zap- 70 complex, and effector CD4 + T cells express ...
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Role and Regulation of the Actin-Regulatory Protein Hs1 in Tcr Signaling
... facilitate TCR signaling by bringing interacting molecules together, the c-SMAC was subsequently shown to be a site where signaling is terminated by internalization of TCR signaling ...
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TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice
... upon TCR stimulation (Fig- ure ...of TCR signaling and, hence, cytokine ...by TCR stimulation (Figure 6, A and C) may suggest the involvement of transcriptional and posttranslational ...TLR4 ...
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T cell receptor signaing controls Foxp3 expression via PI3K, Akt and mTOR
... without TCR stimulation for 36 h ...no TCR signaling). Hence, the continued availability of TCR signals appeared to control Foxp3 expression in newly activated CD4 T ...cells. TCR/ CD28 ...
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Costimulating aberrant T cell responses by B7 H1 autoantibodies in rheumatoid arthritis
... 3c). TCR signaling was also required for proliferation, because B7-H1 mAb did not stimulate T cell proliferation in the absence of anti-CD3 mAb (Figure ...
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The Role of Slp-76 Phosphotyrosines in TCR Signal Transduction and T Cell Differentiation
... the TCR (Lin and Weiss, ...the TCR signaling cascade, how it is regulated remains largely ...of TCR triggering – how ligation of the extracellular domain of the TCR complex results in ...
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Baseline T cell dysfunction by single cell network profiling in metastatic breast cancer patients
... that TCR signaling was not corrected by treat- ment with fresolimumab and ...increase TCR signaling in PD-1 + CD4 T cells in baseline samples, suggesting a role for the PD-1 pathway in ...
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Association of Herpesvirus Saimiri Tip with Lipid Raft Is Essential for Downregulation of T-Cell Receptor and CD4 Coreceptor
... receptor signaling and ...of TCR signal transduction, and the activation of STAT3 transcription ...of TCR and CD4 surface ...inhibiting TCR signaling and activating STAT3 transcription ...
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Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
... chronic TCR-A2 (self)-interactions on tumor-redirected A2 pos CD8 T cells upon TCR trans- duction of increased affinities led to the co-expression of multiple inhibitory receptors such as PD-1, TIM-3, TIGIT ...
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Antigen receptor signaling in the rheumatic diseases
... resembles TCR signaling in many ways, relying upon the ITAMs of the associated Igα and Igβ chains, the B-cell-expressed SFKs Lyn, Fyn, and Blk, and the Syk kinase as well as homologous adaptors (Blnk/Slp-65 ...
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Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia
... In general, the TCRζ mRNA stability is mainly in- fluenced by its downstream 3'-UTR. While the 906 bp WT 3'-UTR plays an important role in TCRζ transcript stability, the 344 bp alternatively spliced 3'-UTRsignifi- cantly ...
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Latent Gammaherpesvirus 68 Infection Induces Distinct Transcriptional Changes in Different Organs
... Cytokine Signaling in Immune system Interferon Signaling Immunoregulatory interactions between Cell adhesion molecules (CAMs) Chemokine signaling pathway T Cytotoxic Cell Surface Molecules Hemostasis ...
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Signals Controlling Regulatory T Cell Differentiation and Homeostasis
... Treg TCR with cognate antigen presented on MHCII enhanced Treg division beyond that observed with IL-2 and MHCII KO DCs ...of TCR signaling in vivo. While Tregs do require TCR signaling ...
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A CD22-reactive TCR from the T-cell allorepertoire for the treatment of acute lymphoblastic leukemia by TCR gene transfer
... compartment TCR-engineered T-cells could additionally be equipped with suicide genes to deplete the administered T-cell product from circulation after successful eradication of the malignancy ...surveilling ...
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Opportunities and Challenges for Antibodies against Intracellular Antigens
... of TCR-like ...of TCR-like antibodies, new key targets for the treatment of cancer have been discovered ...strategies, TCR-like antibodies can be bivalent IgG isotype antibodies produced through ...
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TCR-like antibodies in cancer immunotherapy
... first TCR-like antibody targeting human tumor antigens ...the TCR-like antibody bound to the MAGE-1+/HLA-A1+ melanoma cells, indi- cating that the phage library-derived Fabs could recognize the native ...
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Improved Assessment of T-Cell Receptor (TCR) VB Repertoire in Clinical Specimens: Combination of TCR-CDR3 Spectratyping with Flow Cytometry-Based TCR VB Frequency Analysis
... each TCR VA or VB family, and the area under the curve for each individual CDR3 peak is ex- pressed as the percentage of the entire CDR3 ...each TCR VA/VB fam- ily; alternatively, the entire TCR VA ...
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TCR size minimum providing small
... reactors, TCR size minimum providing small percentages of nontriplen harmonics, facilitates stepless variation of reactive power depending on load requirement so as maintain power factor near unity ...
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