TCR, T-cell receptor
T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone
... effector cell/stimulator cell ratio of 1:1 at 37°C or GXR cells not loaded with peptide as a negative ...⫹ T-cell clonotypes was analyzed by hierarchical cluster ...
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Improved Assessment of T-Cell Receptor (TCR) VB Repertoire in Clinical Specimens: Combination of TCR-CDR3 Spectratyping with Flow Cytometry-Based TCR VB Frequency Analysis
... variable TCR alpha chain and with 24 individual primers specific for the TCR beta chain as described previously (8, ...fluorophore-labeled TCR C-alpha chain-specific primer (5⬘-AT ...
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Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure
... single TCR recognizes peptides that are highly distinct in their primary sequences (2, 13, ...the TCR, MHC, and antigenic peptides has important implications for better prediction of cross-reactivity in ...
8
Cancer testis antigen and immunotherapy
... stem cell transplantation; CT, cancer testis; R, recruiting; TCR, T cell receptor; TLR3, toll-like receptor 3; MAGE-A1, melanoma antigen family A, 1; MAGE-A3, melanoma antigen ...
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Myelin basic protein specific T lymphocyte repertoire in multiple sclerosis Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones
... human T cell response to the myelin basic protein (MBP) has been studied with respect to T cell receptor (TCR) usage, HLA class II restriction elements, and epitope specificity ...
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Restricted usage of T cell receptor V alpha V beta genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy
... infiltrating T cells and persistence of viral genomes in the myocardial tissue, we analyzed the expression of T cell receptor (TCR) V alpha and V beta genes as well as enterovirus ...
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Clonal T cell responses in tumor infiltrating lymphocytes from both regressive and progressive regions of primary human malignant melanoma
... The T cell receptor (TCR) BV variable (V) gene repertoire of tumor infiltrating lymphocytes (TIL) found in progressive and regressive regions of the same primary human melanomas were ...
7
Radiation leukemia virus-induced thymic lymphomas express a restricted repertoire of T-cell receptor V beta gene products.
... By the combined use of antibodies against the envelope glycoprotein gp7O of RadLV, the transformation-associated cell surface marker lC1l, and the CD3-T-cell receptor TCR complex, we fou[r] ...
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Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis
... of T cell specificities in the synovial fluid of patients has been taken as evidence for a local stimulation of T ...the T cell receptor (TCR) repertoire of CD4+ T ...
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Functional T-Cell Deficiency in Adolescents Who Experience Serogroup C Meningococcal Disease despite Receiving the Meningococcal Serogroup C Conjugate Vaccine
... or T-cell ...mimic T-cell-independent B-cell stimulation by bacterial polysaccha- rides and the T-cell stimulation provided by the protein component of the conjugate ...of ...
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Therapeutic cancer vaccines
... adoptive T cell transfer ...transferred T cells (frequently expanded TILs) appears to determine the thera- peutic efficacy of ...of T cells transduced with an avidity -enhanced, ...
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Gene expression pattern of TCR repertoire and alteration expression of IL 17A gene of γδ T cells in patients with acute myocardial infarction
... And T cells are further subdivided into two major populations characterized by the surface expression of a T cell receptor (TCR) α chain and a β chain (αβ T cells) or a γ chain ...
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Presence of Oligoclonal T Cells in Cerebrospinal Fluid of a Child with Multiphasic Disseminated Encephalomyelitis following Hepatitis A Virus Infection
... -chain T-cell receptor (TCR) transcripts from the cerebrospinal fluid (CSF) and peripheral blood from a 7-year old child who developed a multiphasic disseminated encephalomy- elitis following ...
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Alterations in T-Cell Receptor Vβ Repertoire of CD4 and CD8 T Lymphocytes in Human Immunodeficiency Virus-Infected Children
... the T-cell receptor (TCR) V  repertoire were assessed in the CD4 and CD8 T lymphocytes of human immunodeficiency virus (HIV)-infected children who were receiving therapy during the ...
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Regulation of the mature human T cell receptor gamma repertoire by biased V J gene rearrangement
... delta T cell repertoire, we generated T cell receptor gamma (TCR gamma) V domain-specific cDNA libraries from the peripheral lymphocytes of eight donors and sequenced a total of ...
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Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance
... T cell sorting and TCR sequencing. Epitope-specific T cells were la- beled with appropriate major histocompatibility complex class I (MHC-I) tetramers and sorted by fluorescence-activated ...
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Cells of the synovium in rheumatoid arthritis T lymphocytes
... of T-cell responses in rheumatoid arthritis (RA) is initiated by T-cell receptor (TCR) interaction with shared epitope major histocompatibility complex class II (MHCII-SE) and ...
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The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL.
... a TcR V b 17 gene rearrangement ...1 T cells from donor 001 bore TcR V b ...of TcR V b -specific MAbs can identify only about 60% of the known TcR V b gene segments, and we note that ...
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Selective activation and accumulation of oligoclonal V beta specific T cells in active pulmonary sarcoidosis
... activated T cells, responding to an unidentified stimulus, accumulate at sites of disease such as the ...of T cell receptor (TCR) specific T cells, we analyzed TCR V beta ...
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T cell receptor delta gene rearrangements in acute lymphoblastic leukemia
... the TCR-delta gene and genomic probes, we have analyzed T cell receptor (TCR) delta gene rearrangement in 19 patients with T cell acute lymphoblastic leukemia ...
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