telomere maintenance
Functional Analysis of the Single Est1/Ebs1 Homologue in Kluyveromyces lactis Reveals Roles in both Telomere Maintenance and Rapamycin Resistance
... in telomere maintenance ...pombe telomere protein Ccq1 rather than a Cdc13 homologue ...in telomere regulation, though their mechanisms of action appear to be distinct from that of ScEst1 (35, ...
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Innate sexuality determines the mechanisms of telomere maintenance
... Recently, telomere length has been shown to be differentially regulated in asexu- ally and sexually reproducing ...maintain telomere length somatically during reproduction by fission or when regeneration is ...
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DNA–dependent protein kinase in telomere maintenance and protection
... Telomerase is a ribonucleoprotein complex that contains a catalytic telomerase reverse tran- scriptase (TERT) subunit and an integral telomerase RNA component (Terc, also referred to as TR, telomerase RNA) subunit for ...
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The Saccharomyces cerevisiae mre11(ts) Allele Confers a Separation of DNA Repair and Telomere Maintenance Functions
... and telomere maintenance functions and that Mre11-Rad50-Xrs2 complex formation appears to be essential for both of these ...temperature-independent telomere shortening, indicating that mre11(ts) is a ...
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Need telomere maintenance? Call 911
... progressive telomere shortening and loss of germ- line immortality ...for telomere length maintenance ...mild telomere length changes, although some effects appear to be laboratory or strain ...
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Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms
... Telomere maintenance mechanisms show adaptation in asex- uals is achieved at the level of Smed-tert ...increase telomere length by producing seven- to eightfold more TRBD- containing ...
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Variations in telomere maintenance and the role of telomerase inhibition in gastrointestinal cancer
... proper telomere maintenance and protection of chromosomal ...Six telomere-associated proteins form the shelterin complex that serves as a telomere cap and is involved in the regulation of ...
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Isolation and characterization of genes involved in DNA damage response and telomere maintenance in Caenorhabditis elegans
... pathways. Telomere replication mutants, such as mrt-2, a subunit of the 9-1-1 complex, and trt-1, the telomerase reverse transcriptase, become sterile under all growth conditions, including 20°C, and near ...
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EXO1 Contributes to Telomere Maintenance in Both Telomerase-Proficient and Telomerase-Deficient Saccharomyces cerevisiae
... the telomere length defect in a yku80⌬ strain, demonstrating that exonuclease action can directly contribute to telomere ...enhancing telomere function and consequently cell proliferation, by ...
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The Mre11p/Rad50p/Xrs2p Complex and the Tel1p Function in a Single Pathway for Telomere Maintenance in Yeast
... plex could increase accessibility of telomeric DNA to telomerase. Two further points should be mentioned. First, Tel1p and the MRX complex could affect accessi- bility of the telomere to cellular exonucleases as ...
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Nuclear localization of Desmoplakin and its involvement in telomere maintenance
... the telomere, the DSP was split into N-terminal and C-terminal fragments with both containing the NLS and being fused with EGFP (Fig ...the telomere FISH signal (Fig ...of telomere (Fig 3D, red ...
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Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells
... and telomere maintenance is emerging as an attractive target for anticancer ...at telomere, which may result from uncapping and disassembly of telomeric T-loop structure, characterized by the ...
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Altered mRNA Expression of Telomere-Associated Genes in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma
... the telomere maintenance genes, TRF1, TRF2 and TANK1 in patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma ...expression, telomere length (TL) and ...
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Complex roles for telomeres and telomerase in breast carcinogenesis
... If telomere dysfunction aids in formation of genomic rearrangements that facilitate cancer formation, then telomerase reactivation later in the course of carcinogene- sis probably favors tumor ...Re-establishing ...
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Mutations in Mre11 Phosphoesterase Motif I That Impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 Complex Stability in Addition to Nuclease Activity
... The telomere length of the strain with mre11-D16A in high copy was not restored to the length observed in the mre11-D56A, suggesting that other functions at the telomere might be impaired by the mre11-D16A ...
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Telomere Binding of Checkpoint Sensor and DNA Repair Proteins Contributes to Maintenance of Functional Fission Yeast Telomeres
... the telomere lengths of checkpoint sensor was deleted along with tel1⌬ and ...made telomere length more ute positively to telomere maintenance both through a homogeneous compared to a pku70⌬ ...
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The Principal Role of Ku in Telomere Length Maintenance Is Promotion of Est1 Association with Telomeres
... but telomere elonga- tion is still reduced in the absence of telomere-bound ...the telomere, Est2 is recruited to telomeres via the Cdc13–Est2 fusion, and TLC1 is in the nucleus yet the ...
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Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease
... for telomere maintenance in PARN-mutant cells and that PAPD5 inhibition is sufficient to counteract the effects of PARN deficien- cy by restoring TERC levels, telomerase activity, and telomere ...
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Growing old, yet staying young: The role of telomeres in bats' exceptional longevity
... that telomere maintenance in this species is unlikely to be mediated by ...in telomere maintenance genes suggest that ATM and SETX, which function to repair and prevent DNA damage, may ...
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The diagnosis and treatment of dyskeratosis congenita: a review
... defective telomere maintenance and is heterogeneous at the genetic ...ten telomere- and telomerase-associated genes have been described in ...
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