tenascin-C
The role of tenascin C in cardiovascular disease
... Tenascin C (TnC) is a large extracellular matrix glycoprotein and was the first member identified of a family of 4 structurally similar proteins including tenascin R, W and X 1-3 ...
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Comparative Gene Approach to the Investigation of SNPs within the Tenascin C Gene in Achilles Tendon Injury in the Canine Patient
... maintaining fibrocartilaginous regions by decreasing cell-matrix adhesion 18 . TNC expression is also increased in acute tendon injury in association with disorganised regions of tendon matrix 17 . A 6-fold increase in ...
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Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C
... these, tenascin C (TNC), is highly expressed within the SVZ throughout postnatal and adult life (Gates et ...and tenascin C-deficient neural stem cells both in vivo and when grown in cell ...
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Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin C antisense prevents progression, of vascular disease
... Increased expression of the glycoprotein tenascin-C (TN) is associated with progression of clinical and experimental pulmonary hypertension. In cultured smooth muscle cells (SMCs) TN is induced by matrix ...
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Association of invasion promoting tenascin C additional domains with breast cancers in young women
... Structurally TNC comprises a linear arrangement of domains, with a cysteine-rich N-terminus followed by 14.5 epidermal growth factor-like repeats, a region of fibronectin type III-like repeats and a fibrinogen-like ...
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Serum tenascin C discriminates patients with active SLE from inactive patients and healthy controls and predicts the need to escalate immunosuppressive therapy: a cohort study
... Tenascin-C (TNC) is a large extracellular matrix glycoprotein that belongs to the damage-associated mo- lecular patterns family [4]. Little TNC is found in most healthy adult tissues, because it is ...
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The extracellular matrix molecule tenascin C modulates expression levels and territories of key patterning genes during spinal cord astrocyte specification
... The lumbosacral spinal cord of the embryo was dissected using small forceps and the surrounding meninges were removed. The tissue was enzymatically digested using 30 U/ml papain (Worthington, New Jersey, USA) in MEM ...
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Stromal integrin α11 regulates PDGFRβ signaling and promotes breast cancer progression
... fibroblast-derived tenascin C is a key matricellular protein that promotes tumor cell invasion (14, 55, ...regulate tenascin C expres- sion (43, ...and tenascin C expression, ...
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Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway
... Paracrine signaling from lung epithelium to the surrounding mesenchyme is important for lung SMC develop- ment and function and is a contributing factor in an array of pulmonary diseases such as bronchopulmonary ...
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Tumour associated tenascin C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase dependent and independent mechanisms
... which will impact on their behaviour. One of the most consist- ent changes in the ECM of many solid tumours is up-regulation of the matrix glycoprotein, tenascin-C (TNC) [6-8]. TNC is a complex ...
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Tenascin-C serum levels and its prognostic power in non-small cell lung cancer
... of Tenascin C in tumor tissue and corresponding serum levels is in line with the well-established idea of a relationship between inflammation and ...
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Mapping tenascin C interaction with toll like receptor 4 reveals a new subset of endogenous inflammatory triggers
... of tenascin-R may be physically constrained in a way that precludes TLR4 binding under normal ...of tenascin-R expression upon injury may create tissue concentrations above the threshold of TLR4 detection, ...
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Raised circulating tenascin C in rheumatoid arthritis
... Circulating tenascin-C (TNC) is raised in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), idiopathic inflammatory myositis (IIM), psoriatic arthritis (PSA) and ankylosing spondylitis (AS) ...
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Airway epithelial cells generate pro-inflammatory Tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection
... CXCL8, C-X-C Motif Ligand 8; ECM, Extracellular Matrix Protein; ELISA, Enzyme-Linked Immunosorbent Assay; FNIII, Fibronectin Type III-Like; EGF, Epidermal Growth Factor-Like; EV, Extracellular Vesicle; ...
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Interleukin-1 has opposing effects on connective tissue growth factor and tenascin-C expression in human cardiac fibroblasts.
... Kalembeyi, I., Inada, H., Nishiura, R., Imanaka-Yoshida, K., Sakakura, T., Yoshida, T., 2003. Tenascin-C upregulates matrix metalloproteinase-9 in breast cancer cells: direct and synergistic effects with ...
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Airway Epithelial Cells Generate Pro-inflammatory Tenascin-C and Small Extracellular Vesicles in Response to TLR3 Stimuli and Rhinovirus Infection
... CXCL8, C-X-C Motif Ligand 8; ECM, Extracellular Matrix Protein; ELISA, Enzyme-Linked Immunosorbent Assay; FNIII, Fibronectin Type III-Like; EGF, Epidermal Growth Factor-Like; EV, Extracellular Vesicle; ...
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Expression of N cadherin, N CAM, fibronectin and tenascin is stimulated by TGF beta1, beta2, beta3 and beta5 during the formation of precartilage condensations
... N-CAM, tenascin and fibronectin to higher levels than the other TGF- β ...that tenascin is stimulated in higher proportion than other molecules, followed by N-cadherin, fibronectin and ...
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Cardiac remodeling in postischemic end stage human hearts: Involvement of extracellular matrix and angiogenesis related molecules
... Background: Extracellular matrix (ECM) partici- pates in heart growth and influences cardiac stem-cell differentiation and migration. The modification of ECM associated with cardiomyopathies is a complex process ...
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Proteomic analysis of stromal proteins in different stages of colorectal cancer establishes Tenascin-C as a stromal biomarker for colorectal cancer metastasis
... Twenty-seven cases of fresh colonic tissues, including 5 cases of non-neoplastic colonic mucosa (NNCM), 8 cases of adenomatous colon polyps (ACP), 5 cases of colon carcinoma in situ (CCIS) and 9 cases of invasive colonic ...
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Tenascin-C is increased in atherothrombotic stroke patients and has an anti-inflammatory effect in the human carotid artery
... A crucial element of the explant culture work is the fact that all the proteins upregulated in the culture system are only derived from the cells of the tissue itself representing a chronic response. This demonstrates ...
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