Tenascin C
Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E
... T-helper cell type 2 (Th2) and type 2 innate lymphoid cells, which secrete Th2 cytokines such as interleukin (IL)-4 and IL-13, are believed to drive asthma pathobiology [7, 8]. Previous microarray analyses identified ...
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Original Article Tenascin-C is a diagnostic marker for cervical cancer and a potential marker for cancer-associated fibroblasts in cervical carcinoma
... Cervical carcinoma is the third leading cause of cancer-related death in women worldwide. Cervical cancer cells require a laminin-rich fibrillar matrix for their invasion, creating an imbalance between various components ...
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Tenascin-C serum levels and its prognostic power in non-small cell lung cancer
... The statistical analysis was performed using SPSS Statistics for Windows (Version 20, SPSS Inc., Chicago Ill, USA). Interdependence between ELISA results and clinical data was calculated using Chi-square and Fisher’s ...
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Association of invasion promoting tenascin C additional domains with breast cancers in young women
... the Tenascin-C invariant exon 17/18 boundary (Applied Biosystems Taqman Assay, Hs01115654_m1) and hypoxanthine phosphoribosyl- transferase 1 (Applied Biosystems Taqman Assay, Hs99999909_m1) as a ...
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Characterization of monoclonal antibodies against tenascin C: no apparent effect on kidney development in vitro
... Inl J Dev BioI 41 39 4R (1997) 39 Original Article Characterization of monoclonal antibodies against tenascin C no apparent effect on kidney development in vitro JAN F TAL TS' HUBERTENG' HONG VAN ZHAN[.] ...
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Interleukin-1 has opposing effects on connective tissue growth factor and tenascin-C expression in human cardiac fibroblasts.
... (Frangogiannis, 2012). However, unlike structural matrix proteins, they do not play a principal role in tissue architecture, but serve as biological mediators of cell function by interacting with cells directly or by ...
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Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin C antisense prevents progression, of vascular disease
... Increased expression of the glycoprotein tenascin-C (TN) is associated with progression of clinical and experimental pulmonary hypertension. In cultured smooth muscle cells (SMCs) TN is induced by matrix ...
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Tenascin-C predicts poor outcomes for patients with colorectal cancer and drives cancer stemness via Hedgehog signaling pathway
... Tenascin-C (TNC) is a large extracellular matrix glycoprotein that is characterized by a six-armed qua- ternary structure and a modular construction [6]. It is composed of four subunits: a cysteine-rich ...
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Proteomic analysis of stromal proteins in different stages of colorectal cancer establishes Tenascin-C as a stromal biomarker for colorectal cancer metastasis
... of Tenascin-C and S100A9 using immunohistochemical analysis, and found that the expression levels of S100A9 and Tenascin-C were correlated with TNM stages and ...that Tenascin-C ...
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Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway
... Given the importance of Wnt signaling in lung epithelial- mesenchymal interactions and lung development in general, we sought to define the molecular program acting downstream of Wnt7b and β-catenin signaling in the ...
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Genomic alterations of Tenascin C in highly aggressive prostate cancer: a meta-analysis
... Tenascin C (TNC), an extra-cellular matrix (ECM) family gene, is expressed in several cancer tissues of breast, lung, colon, and gastrointestinal tract leading to proliferation, migration, invasion, ...
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Article: Dextran sulfate sodium-induced colitis mice up-regulated extracellular matrix tenascin-C
... areas of ulceration, and sera of patients with active ulcerative colitis and Crohn’s disease. On the other hand, recent researches on tenascin-C (-/-) mice were evidenced that deletion of ...
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<p>Exosomal Tenascin-c induces proliferation and invasion of pancreatic cancer cells by WNT signaling</p>
... Tenascin-c (TNC) is an extracellular matrix (ECM) protein with multiple functions and multiple molecular forms due to alternative splicing and protein modi fi cation. 6 TNC is rare or absent in fully ...
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Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease
... disease. Tenascin-C (TNC) is a large extracel- lular matrix (ECM) glycoprotein that mediates cell-cell and cell-matrix interactions [7], and functions in early cell fate determination in the central nervous ...
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The influence of bisphosphonates on human osteoblast migration and integrin aVb3/tenascin C gene expression in vitro
... [6]. Tenascin as well influences cell shape and inhibits the activity of the focal adhesion kinase, an intracellular protein binding the integrins and accumulating vinculin, talin and a-actinin in the focal ...
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Effect of postconditioning on dynamic expression of tenascin-C and left ventricular remodeling after myocardial ischemia and reperfusion
... Tenascin-C (TNC), an extracellular matrix glycopro- tein, could provide important biological signaling that influences cell motility, proliferation, differentiation, sur- vival, or apoptosis via ...
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Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C
... these, tenascin C (TNC), is highly expressed within the SVZ throughout postnatal and adult life (Gates et ...and tenascin C-deficient neural stem cells both in vivo and when grown in cell ...
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Comparative Gene Approach to the Investigation of SNPs within the Tenascin C Gene in Achilles Tendon Injury in the Canine Patient
... maintaining fibrocartilaginous regions by decreasing cell-matrix adhesion 18 . TNC expression is also increased in acute tendon injury in association with disorganised regions of tendon matrix 17 . A 6-fold increase in ...
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The co-expression of MMP-9 and Tenascin-C is significantly associated with the progression and prognosis of pancreatic cancer
... TN- C expression, this co-expression and co-location of MMP-9 with TN-C in pancreatic cancer may imply that MMP-9 helps TN-C incorporate into the stroma to form tube-shaped structures named “tubular ...
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Fibronectin and tenascin C: accomplices in vascular morphogenesis during development and tumor growth
... encoding tenascin-C is also located on chromosome 4, at a distinct ...that tenascin-C could participate in genetic interactions that determine the severity of the ...
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