terminal deletion
Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants
... intragenic deletion of carboxy- terminal coding ...C-terminal deletion mutants are efficiently inhibited by EGFR-targeted drugs including erlotinib, afatinib, dacomitinib as well as cetuximab, ...
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The Expression of N-Terminal Deletion DNA Pilot Proteins Inhibits the Early Stages of φX174 Replication
... The ⌬ H proteins inhibit early stages of DNA synthesis, which does not require de novo H protein synthesis. There are several mechanisms by which the H protein could lead to elevations in viral protein synthesis. It ...
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Functional Analysis of Carboxy-Terminal Deletion Mutants of c-Myb
... C-terminal deletion mutants of c-Myb all displayed the same ...c-Myb deletion mutants generally have a growth dependency on feeder cells which secrete ...
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Nuclear localized Influenza nucleoprotein N terminal deletion mutant is deficient in functional vRNP formation
... To address the role of N-terminal NP interactions inside the host cell, we set out to construct a plasmid encoding an N-terminal NP deletion mutant able to localize to the nucleus, where viral RNA ...
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Transformation of avian fibroblasts overexpressing the c-rel proto-oncogene and a variant of c-rel lacking 40 C-terminal amino acids.
... Cytoplasmic localization could be due to interaction with IKB molecules, and in fact, the overexpression of c-Rel or the C-terminal deletion construct of c-Rel resulted in an increase in[r] ...
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TEMPERATURE EFFECTS ON LETHAL MUTATION RATES OF HABROBRACON OöCYTES X-IRRADIATED IN FIRST MEIOTIC METAPHASE
... One result obtained in the present study, difficult to reconcile with the theory of tension and the facts of terminal deletion and lateral fusion to explain the extreme [r] ...
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Ebola Virus VP40-Induced Particle Formation and Association with the Lipid Bilayer
... C-terminal deletion of amino acids 177 to 326 resulted in a protein with much higher affinity for the lipid bilayer than was found for wild-type ...hydrophilic. Deletion of the hydrophilic residues ...
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Identification of Amino Acid Residues Critical for the Anti-Interferon Activity of the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus
... We next examined the ability of C-terminal mutants of LCMV NP to inhibit an IFN-responsive promoter and to sup- port viral replication in the LCMV MG assay. For this, we generated a collection of C-terminal ...
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Origin of Expression of the Herpes Simplex Virus Type 1 Protein US1.5
... N-terminal deletion mutants of ICP22 with those of bands detected in pAlter22-transfected, d22:GFP-infected ...ICP22 deletion mutants was constructed by PCR and cloned into pCDNA3 ...
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Further phenotypic delineation of subtelomeric (terminal) 4q deletion with emphasis on intracranial and reproductive anatomy
... Conclusion: Terminal deletion of the long arm of chromosome 4 is a rare genetic event associated with a distinctive phenotype dependent on the size of the ...
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Alternative splicing of a beta(4) subunit proline-rich motif regulates voltage-dependent gating and toxin block of Ca(v)2.1 Ca2+ channels
... N-terminal deletion and site-directed mutagenesis experiments revealed that the effects of alterna- tive splicing on toxin block and all aspects of gating could be attributed to a prolin[r] ...
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Apparent uncoupling of oncogenicity from fibroblast transformation and apoptosis in a mutant myc gene transduced by feline leukemia virus.
... N-terminal deletion in T17 v-myc is the most likely source of its fibroblast transformation defect, since the dele- tion overlaps with a number of engineered deletion mutations which have been shown ...
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Radicicol-Mediated Inhibition of Topoisomerase VIB-VIA Activity of the Human Malaria Parasite Plasmodium falciparum
... three deletion constructs of PfTopoVIB and tested their ability to engage with ...N-terminal deletion mutant of PfTopoVIB (amino acids 280 to 561) for our ...three deletion constructs of ...
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Dissecting the Role of the N-Terminal Domain of Human Immunodeficiency Virus Integrase bytrans-Complementation Analysis
... Cross-complementation activity between FIV and HIV-2 IN mutants. Previously, it has been shown that HIV IN and FIV IN have different preferences for viral DNA substrates, as well as different target site choices. To ...
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Structural Requirements for the Assembly of Norwalk Virus-Like Particles
... the deletion mutants in which either the entire P domain (CT303) or a significant portion of the P domain (CT230) was deleted, eliminating the interactions between the P and S do- mains, the effect is ...
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Terminal 22q Deletion Syndrome: A Newly Recognized Cause of Speech and Language Disability in the Autism Spectrum
... Results. Age of presentation ranged from 5 months to 46 years. There were 10 female patients and 1 male pa- tient. All of the patients exhibited delayed motor devel- opment, some degree of hypotonia, and severe ...
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The HTLV 1 Tax protein binding domain of cyclin dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix
... minal amino acids of Tax to bind CDK4 in a yeast two- hybrid system and in pull down analyses [39]. In exten- sion, we demonstrated the interaction with naturally folded CDK4 protein produced in human cells. The bind- ...
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The Longin Domain Regulates the Steady-State Dynamics of Sec22 in Plasmodium falciparum
... for ykt6 gene products, to regulate the SNARE activity (18, 21, 32, 35, 39, 53). The longin domain of PfSec22 exhibits signifi- cant differences from yeast and human orthologs, which might influence its cellular ...
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Endo-N-Acetyl-β-D-Glucosaminidases and Peptide-N4-(N-acetyl-β-D-Glucosaminyl) Asparagine Amidases: More Than Just Tools
... Endo F was detected in an endoglycosidase activity produced by Flavobacterium meningosepticum [83]. This bacterium was later reclassified as Chrysobacterium meningosepticum [84] before being transferred into ...
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Hepatitis B Virus Nucleocapsids Formed by Carboxy-Terminally Mutated Core Proteins Contain Spliced Viral Genomes but Lack Full-Size DNA
... described deletion variant lacking the 19 C-terminal amino acid residues, for their ability to support viral replication in transfected hepatoma ...the deletion gave rise to nucleocapsids containing ...
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