TERMINAL DIFFERENTIATION
C elegans SoxB genes are dispensable for embryonic neurogenesis but required for terminal differentiation of specific neuron types
... and differentiation in various ...the terminal differentiation of specific neuronal cell ...controlling terminal differentiation programs of specific neuron types, but not in broadly ...
14
Tif1γ is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition
... Transforming growth factor (TGF) is widely recognised as an important factor that regulates many steps of normal mammary gland (MG) development, including branching morphogenesis, functional differentiation and ...
9
p16INK4a and its regulator miR 24 link senescence and chondrocyte terminal differentiation associated matrix remodeling in osteoarthritis
... chondrocyte terminal differenti- ation within the growth plate to coordinate matrix remod- eling that promotes bone growth [12] but also in OA articular cartilage during disease progression ...p107-dependent ...
12
Changes in integrin expression during keratinocyte terminal differentiation and immortalisation
... Experiments similar to those carried out by Reszka and co-workers (Reszka et al., 1992) would further clarify the contribution of the pi-integrin subunit cytoplasmic tail in the mechanism of integrin-cadherin ...
197
Hand2 is necessary for terminal differentiation of enteric neurons from crest derived precursors but not for their migration into the gut or for formation of glia
... Hand genes are expressed in developing mouse (Cserjesi et al., 1995; Hendershot et al., 2007; Hollenberg et al., 1995) and chick (Wu and Howard, 2002) gut. In situ hybridization has suggested that Hand2 is expressed in ...
13
Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9
... The terminal differentiation of hypertrophic chondrocytes is a tightly regulated process that plays a pivotal role in endochondral ...the terminal differentiation of hypertrophic chondrocytes ...
9
Induction of terminal differentiation in human K562 erythroleukemia cells by arabinofuranosylcytosine
... We have previously demonstrated that continuous exposure of human HL-60 human promyelocytes to 1-beta-D-arabinofuranosylcytosine (ara-C) results in the induction of terminal differentiation to monocyte-like ...
8
The role of ceramide in growth arrest and terminal differentiation of human leukaemia cells
... In a recent study we demonstrated that ceramide caused terminal differentiation of the U937 monoblastic leukaemia cells that was characterised by cell cycle arrest and activation of the [r] ...
386
Measles Virus Infection Induces Terminal Differentiation of Human Thymic Epithelial Cells
... cell differentiation process: attached measles virus-infected epithelial cells correspond to an intermediate state of differentiation while floating cells, recovered from cell culture supernatants, are ...
10
Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila
... Protein phosphatase type 2A complex (PP2A) has been known as a tumor suppressor for over two decades, but it remains unclear exactly how it suppresses tumor growth. Here, we provide data indicating a novel role for PP2A ...
13
PPARγ agonist through the terminal differentiation phase is essential for adipogenic differentiation of fetal ovine preadipocytes
... adipogenic differentiation of oPADs and formation of medium to large sized lipid droplets ...this differentiation protocol, lipid accumu- lation is readily visible under light microscope starting at day 3 ...
12
GABA induces terminal differentiation of Dictyostelium through a GABAB receptor
... As the induction of sporulation by GABA is mediated by SDF-2 binding to its receptor DhkA, GABA must induce not only release of AcbA from prespore cells but also exposure of the TagC pro[r] ...
9
Interferons Mediate Terminal Differentiation of Human Cortical Thymic Epithelial Cells
... Cells were either treated with mock supernatant, treated with UV-MV, or infected with MV and cultured in the pres- ence of either neutralizing anti-IFN-␣ or anti-IFN- polyclonal antibodies. Because IFN-␣/ were ...
10
The ability of synoviocytes to support terminal differentiation of activated B cells may explain plasma cell accumulation in rheumatoid synovium
... differentiation of B cells into mature plasma cells with typical morphology, high levels of intracytoplasmic Igs, and CD20- CD38high surface expression. The present observation should permit the identification of ...
9
Differentiation of Myeloid Cell Lines Correlates with a Selective Expression of RIZ Protein
... the terminal differentiation of promyelocytes induced by ATRA or other agents, RIZ1 expression was forced in HL60 cells by infec- tion with a recombinant adenovirus (AdRIZ1) lacking the E1A and E1B regions ...
9
GATA family transcriptional factors: emerging suspects in hematologic disorders
... the terminal differentiation of these cells [3, ...N terminal zinc finger cofac- tors such as FOG-1 (Friend of GATA) is essential for megakaryocyte or erythroid development ...and ...
7
Single-cell transcriptomics–based MacSpectrum reveals macrophage activation signatures in diseases
... AMDI captures transition from preactivated to activated macrophages. Next, we developed a second index, AMDI, to annotate the process from preactivation states (M0) toward fully activated and matured macro- phages ...
22
GATA transcription factors in development and disease
... erythroid differentiation is tightly coupled to the repression of Gata2 transcription through recruitment of EKLF and the SWI/SNF chromatin remodeling ...as differentiation occurs (Ray et ...and ...
20
Sequential changes at differentiation gene promoters as they become active in a stem cell lineage
... and abortive transcript initiation are emerging as a common feature in stem/progenitor cells. This mechanism may prime genes to rapidly respond to developmental cues or environmental stimuli (Muse et al., 2007; ...
10
miR-150 inhibits terminal erythroid proliferation and differentiation
... lineage differentiation according to the procedure described in the methods ...erythroid terminal differentiation (Figure 1A), indicating that miR-150 may have a negative role during erythroblast ...
15