TERT promoter mutation
Original Article TERT promoter mutation, telomere length, and TERT expression in gastric cancer
... of TERT promoter muta- tion in GC had been reported in several studies with ...of mutation in TERT promoter was found in two hot spot, C228T (chr 5: 1295228) and C250T (chr 5: 1295250) ...
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A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas
... of TERT pro- moter mutation as a diagnostic and/or prognostic marker in combination with IDH mutation and MGMT methylation in a large series of newly diagnosed adult gliomas with detailed clinical ...
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High frequency of TERT promoter mutation in small cell carcinoma of bladder, but not in small cell carcinoma of other origins
... the TERT promoter (145 bp) was amplified by PCR. The TERT promoter mutations are determined by bi-directional Sanger ...bear TERT promoter mutation ...the TERT ...
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The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas
... gene promoter (TERTp) are common in glioblastomas (GBMs) and oligodendrogliomas (ODGs), and therefore, have a key role in tumorigenesis and may be of prognostic ...IDH2 mutation ( IDH -mutant) and 1p/19q – ...
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Diffuse gliomas classified by 1p/19q co-deletion, TERT promoter and IDH mutation status are associated with specific genetic risk loci.
... IDH mutation, TERT promoter mutation and 1p/19q co-deletion as cancer drivers in ...and TERT promoter, IDH mutated glioma without 1p/19q co-deletion ...
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TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma
... on TERT expression. TERT mRNA was constitutively downregulated by dab- rafenib ...stimulated TERT expression in BRAF wild-type/ TERT promoter-mutant cells and had no ef- fect in the ...
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Germline TERT promoter mutations are rare in familial melanoma
... POT1, TERT and other shelterin complex gene mutations have been found in melanoma families, suggests that telomere function is critical in melanoma ...of TERT promoter mutation carriers, in ...
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Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma
... of TERT expression ...somatic TERT promoter mutations has reported to further increase TERT transcription levels and to be associated with higher risk of death and cancer recurrence in liver ...
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Implications of TERT promoter mutations and telomerase activity for urothelial carcinogenesis
... of TERT promoter mutations with UCB stage and ...report TERT promoter mutations in 59 to 79% (mean 70%) UCB irrespective of tumour stage or grade 44,100,102,114,115 ...with TERT ...
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TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation
... without TERT, BRAF and NRAS mutations (Table ...express TERT; whereas, melanoma cell lines expressed different levels of TERT (Figure ...of TERT protein in cells lines with and without ...
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MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours
... and TERT promoter mutations are rare in ...to TERT promoter mutation that are consistently found in paired recurrences, including those with multiple ...MED12 mutation in the ...
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Frequent somatic TERT promoter mutations and CTNNB1 mutations in hepatocellular carcinoma
... of TERT and CTNNB1 have been documented in hepatocellular carcinoma. TERT promoter mutations are the earliest genetic events in the multistep process of hepatocarcinogenesis related to ...of ...
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TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities
... MPNSTs, TERT promoter mutations were found in a small fraction of tumors (2/35; 6%), which is slightly below the mutation frequency previously reported (2/12; 17%) ...a TERT promoter ...
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TERT p mutation ( P<0.0001) and simultaneously wild type of IDH and TERT p ( IDH wt TERT pwtP <0.0001) in midline than no-midline lobes. Logistic regression analysis indicated
... approximate mutation rate of each bio- marker across brain ...IDH mutation was identified in 67 of 83 ...IDH mutation (A) and TERT promoter mutation (C) of WHO grade II and III ...
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BRAF and TERT promoter mutations in the aggressiveness of papillary thyroid carcinoma: a study of 653 patients
... on TERT promoter mutation so far, we were able to observe a significant association between BRAF V600E and TERT promoter mutations and demonstrate a robust cooperative role of ...
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Frequency of TERT promoter mutations in prostate cancer
... (PrCa) TERT expression was associated with a poor prognosis and a higher risk for biochemical ...high TERT expression in PrCa are still not clarified in ...on TERT promoter mutation ...
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The C228T mutation of TERT promoter frequently occurs in bladder cancer stem cells and contributes to tumorigenesis of bladder cancer
... wild-type TERT core promoter was cloned upstream of the firefly luciferase ...wild-type TERT promoter, the C228T mutation conferred approximately five-to sevenfold increased ...
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(R) N {2 tert Butyl 2 [(R) tert butylsulfonamido]ethylidene} tert butanesulfonamide
... R-1-Amino-1-tert-butyl-N,N′-bis[(R)- N-tert-butanesulfinyl]-2-iminoethane was prepared from bis-[(R)-N-tert-butane- sulfinyl]ethanediimine (264 mg, 1.00 mmol). The solution of ...
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Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation
... Among the explanations for these differences is a confounding influence of isocitrate dehydrogenase 1 (IDH1) mutations, which are associated with a CpG island methylator phenotype in glioma (GCIMP). 6 Mutations in IDH1 ...
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Targeted gene therapy of nasopharyngeal cancer in vitro and in vivo by enhanced thymidine kinase expression driven by human TERT promoter and CMV enhancer
... its promoter has been widely employed to drive the tumor- specific expression of exogenous ...and TERT-E1A-TK, respectively, both of which can kill lung cancer cells and transplanted tumor in vitro and in ...
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