TGF beta signaling pathway
<p>Nucleolar and Spindle Associated Protein 1 (NUSAP1) Promotes Bladder Cancer Progression Through the TGF-β Signaling Pathway</p>
... various signaling path- ways (TGF- β , Wnt/ β -catenin, Notch, EGF, and ...the TGF- β signaling pathway is widely involved in the EMT of various tumors, and TGFBR1 is an important ...
13
<p>INTS8 accelerates the epithelial-to-mesenchymal transition in hepatocellular carcinoma by upregulating the TGF-β signaling pathway</p>
... We purchased commercially available immortalized human hepatocyte (MIHA and THLE3) and liver cancer cell lines (HCCLM3, HepG2, MHCC-97H, and SK-HEP-1) from the American Type Culture Collection (Manassas, VA, USA). The ...
11
Zoledronate inhibits fibroblasts’ proliferation and activation via targeting TGF-β signaling pathway
... Total protein was extracted using a modified buffer with 0.5% sodium dodecyl sulfate (SDS) containing a protease inhibitor cocktail (Sigma-Aldrich Co., St Louis, MO, USA). Approximately 20 µ g of protein were ...
11
Silver nanoparticles/chitosan oligosaccharide/poly(vinyl alcohol) nanofiber promotes wound healing by activating TGFβ1/Smad signaling pathway
... the TGF β 1/Smad signaling pathway in PVA/COS-AgNPs nanofiber-induced wound healing, the effects of the PVA/COS-AgNPs nanofiber treatment on wounded skin and the mRNA expression of genes associated ...
15
R-spondin2 promotes hematopoietic differentiation of human pluripotent stem cells by activating TGF beta signaling
... key signaling pathways [5, 8, ...Activin/Nodal signaling pathways [14, ...NOTCH signaling pathway plays a vital role in specifying arterial-type definitive HE from hPSCs ...TGFβ ...
13
<p>Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-β/Smad2/3 signaling pathway</p>
... of TGF- β RI and TGF- β RII then lead to the phosphorylation of R-Smads proteins (Smad1, 2, 3, 5, 8), which enter into nucleus together with Smad4 and leading to the transcription of downstream ...years, ...
11
The role of thymine DNA glycosylase (TDG) and DNA demethylation in TGF beta signaling
... complex signaling and gene regulatory network of transcription factors, coregulators, and chromatin modifiers that regulate hundreds of genes in a cell-type specific manner (Massagué, ...the pathway has ...
98
Original Article Upregulation of miR-18 controls the progression of hepatocellular carcinoma by modulating TGF-beta signaling
... The TGF-β-SMAD pathway enhances HCC pro- gression by controlling different stages in the process of cancer cell metastasis, including epithelial-to-mesenchymal transition (EMT) [22, ...of TGF-β-SMAD2 ...
8
Silencing Trim59 inhibits invasion/migration and epithelial-to-mesenchymal transition via TGF-β/Smad2/3 signaling pathway in bladder cancer cells
... against TGF- β , Smad2/3, phosphorylated Smad2 (p-Smad2), p-Smad, vimentin, N-cadherin, and matrix metallopeptidase-9 (MMP-9) were purchased from Cell Signaling Technology (St Louis, MO, ...
10
JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion
... prolonged TGF ...motifs. TGF  - induced expression of the AP1 component JUNB was required for expression of many late invasion- mediating genes, creating a feed-forward regulatory ...WNT pathway ...
16
Original Article Effect of the traditional Chinese medicine Weifuchun on regulating atrophic gastritis through RUNX3/TGF-beta/Smad signaling pathway
... cell signaling), RUNX3 (ab11905, abcam), p21 (ab109520, abcam), TGF-beta2 (ab36495, ab- cam), GAPDH (ab8245, abcam), goat anti- mouse IgG HRP (m21001, Abmart, Shanghai, China), goat anti-rabbit IgG HRP ...
8
<p>Exosomes derived from HCC cells with different invasion characteristics mediated EMT through TGF-β/Smad signaling pathway</p>
... induce cell reprogramming, ultimately enable epithelial phenotype primary tumor cells to acquire interstitial cell characteristics and acquire the ability to invade the extra- cellular matrix, which become the trigger ...
9
<p>The inhibitory effect of oridonin on colon cancer was mediated by deactivation of TGF-β1/Smads-PAI-1 signaling pathway in vitro and vivo</p>
... in TGF- β 1-treated LOVO cells, and inhibited upon oridonin pre-treatment, which suggests that the latter inhibits TGF- β 1-mediated upregulation of PAI-1 by inhibiting the nuclear translocation of Smad2 ...
10
<p>MicroRNA-132 inhibits migration, invasion and epithelial-mesenchymal transition via TGFβ1/Smad2 signaling pathway in human bladder cancer</p>
... against TGF β 1 (1:1000; ab92486), Smad2 (1:800; ab63576), p-Smad2 (1:800; ab53100) and β -actin (1:1000; ab8227; Abcam, Cambridge, MA, UK) were incubated overnight at 4 ...
9
TINAGL1 promotes hepatocellular carcinogenesis through the activation of TGF-β signaling-medicated VEGF expression
... Results: TINAGL1 was upregulated in human HCC tissues and associated with poor prognosis. TINAGL1 knockdown suppressed HCC cell growth, proliferation, and migration and induced apoptosis in HCC cells, whereas TINAGL1 ...
9
Effect of ginseng extract on the TGF β1 signaling pathway in CCl4 induced liver fibrosis in rats
... factor beta (TGF-β), type I TGF-β receptor (TβR-1), type II TGF-β receptor (TβR- II), mothers against decapentaplegic homolog 2 (Smad2), Smad3, Smad4, matrix metalloproteinase2 (MMP2), MMP9, ...
11
Regulation of the JNK pathway by TGF beta activated kinase 1 in rheumatoid arthritis synoviocytes
... Several additional studies indicate that MEKK2 can play a cell- lineage specific role in JNK activation, and our previous studies showed that it could form a functional signaling com- plex in FLSs [20]. MEKK2 also ...
9
Original Article NLRC5 silencing improves cardiac fibrosis by regulation of TGF-β1/Smad3 signaling pathway
... factor beta (TGF-β) plays a pivotal role in mediating cardiac fibroblast function and car- diac fibrosis ...by TGF-β1, and these differentiated cells are actively involved in cardiac fibrosis ...
11
Cytokine expression & TGF-beta signaling in cervical cancer
... Smad signaling within a complex network with other signaling pathways that largely contribute to modifying the initial Smad signals and allows diverse responses to TGF-β1 ...Smad signaling may ...
157
Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway
... Ferulic acid, TGF- β 1, and CCl4 were purchased from Sigma-Aldrich Co. (St Louis, MO, USA). Anti-collagen I, anti-fibronectin, anti- α -SMA, anti-p-p38, anti-p-JNK, anti- p-Smad2, and anti-p-Smad3 antibodies were ...
9