TGF-β signal
Angiotensin II–dependent TGF β signaling contributes to Loeys Dietz syndrome vascular pathogenesis
... did TGF-β–neutralizing antibody fail to afford protection in LDS mice? We observe no in vitro evidence for a cell-autonomous gain of function for mutant TGF-β receptor ...of ...
14
Original Article MicroRNA-664 regulates cell invasion and migration and epithelial-mesenchymal transition by targeting TGF-β signal in glioblastoma
... Abstract: This study aimed to investigate the effects of miR-664 on glioblastoma cell invasion and migration and to reveal its possible molecular mechanisms. The expression of miR-664 was measured by quantitative ...
10
The use of cystatin C to inhibit epithelial–mesenchymal transition and morphological transformation stimulated by transforming growth factor β
... of TGF- β to induce cancer growth and metastasis suggests that developing therapeutics to antagonize and/or circumvent TGF-β signaling may prove effective in treating metastatic malignancies, ...
10
Enhanced NK cell adoptive antitumor effects against breast cancer in vitro via blockade of the transforming growth factor-β signaling pathway
... DNT β RII compared with the TGF- β -mediated phosphorylation of Smad-2 and Smad-3 as observed using Western blotting in parental NK cells and in NK/pTAR-GET ...DNT β RII vector blocked the ...
7
Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models
... affects TGF-β signaling in MDA-MB-231 ...attenuated TGF-β-induced phos- phorylation of Smad2 and Smad3 in a dose-dependent manner (Figure ...inhibited TGF-β-induced PAI-1, CTGF ...
16
TGFβ signaling supports survival and metastasis of endometrial cancer cells
... (TGF β ) type II receptor (RII) with microsatellite instability revealed a signifi cant molecular mechanism of tumorigenesis and tumor progression in gastrointestinal carcinomas with DNA replication ...that ...
10
High tumor-associated macrophages infiltration is associated with poor prognosis and may contribute to the phenomenon of epithelial–mesenchymal transition in gastric cancer
... Conclusion: Our results suggest that high levels of EMT and TAMs infiltration are related to aggressive features and independent prognostic factors in gastric cancer, respectively. A cor- relation was found between EMT- ...
9
TGF-β in pancreatic cancer initiation and progression: two sides of the same coin
... the TGF-β signaling pathways. Three isoforms endow with the TGF-β of mammals, namely TGF-β1, TGF-β2, and TGF-β3 ...Each TGF-β is differentially expressed and ...
7
TGF β superfamily members from the helminth Fasciola hepatica show intrinsic effects on viability and development
... and TGF-β have been identified in all bilateral animals ...[2]. TGF-β super family proteins (particularly Nodal/Activin and BMPs) are essential during early em- bryogenesis and developmental ...
11
Complexities of TGF-β Targeted Cancer Therapy
... of TGF-β is often diverted along alternative pathways. Hence, TGF-β signaling elicits protective or tumor suppressive effects during the early growth-sensitive stages of ...to ...
15
Adenoviral expression of a transforming growth factor-β1 antisense mRNA is effective in preventing liver fibrosis in bile-duct ligated rats
... fibrogenesis, TGF-β is of crucial importance triggering excessive forma- tion and deposition of connective tissue matrix molecules ...[3]. TGF-β binds and signals through distinct heteromeric ...
12
Final
... the TGF-β signaling pathway in hCG treated follicles was determined using Western blot ...for TGF- β pathway components, 1:5000 for ...were TGF-β1 (sc-146), ...
132
Angiotensin II sustains brain inflammation in mice via TGF β
... of TGF-β is a well-known pathophysiological mechanism in animal models of pulmonary, cardiac, and renal fibrosis (2, ...of TGF-β is increased by Ang II and blocked by CA ...of ...
14
Imatinib mesylate inhibits the profibrogenic activity of TGF β and prevents bleomycin mediated lung fibrosis
... of TGF-β signaling through receptor-induced phosphorylation and nuclear trans- ...numerous TGF-β target genes, Smad-indepen- dent pathways have been reported to link TGF-β to ...
10
Inhibiting Cxcr2 disrupts tumor stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
... of TGF-β, especially the effects on the ...intact TGF-β signaling in the stroma promotes stromal cell proliferation and deposition of extracellular matrices as well as Ctgf induction, ...
13
TGF-β inhibits IL-1β-activated PAR-2 expression through multiple pathways in human primary synovial cells
... the TGF-β superfamily of ligands which include TGF-β s and BMPs, is vital for the homeostasis of numerous cellular functions, including cell growth, differentiation, and apoptosis in a broad ...
14
DNA methylation affects metastasis of renal cancer and is associated with TGF-β/RUNX3 inhibition
... and TGF-β were top two downregulated genes in metastatic renal cancer with hypermethylation in CpG islands, while a hypomethyla- tion was observed in the DNA levels of these two ...and TGF-β ...
11
<p>Involvement of TGF-β and ROS in G1 Cell Cycle Arrest Induced by Titanium Dioxide Nanoparticles Under UVA Irradiation in a 3D Spheroid Model</p>
... Cells were harvested, washed with ice-cold PBS, and resus- pended in RIPA lysis buffer containing the protease inhibitor, PMSF. Lysates were sonicated, clari fi ed by centrifugation, and quantitated using a BCA assay kit. ...
14
Original Article Bazedoxifene decreases neuronal apoptosis via transforming growth factor-β-mediated AKT/GSK3β signal pathway in a cerebral hemorrhage rat model
... Mac Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC and Sansing LH. TGF-beta1 modulates microglial phenoty- pe and promotes recovery after ...
9
Distinct roles of Smad pathways and p38 pathways in cartilage specific gene expression in synovial fibroblasts
... Synovium is a thin tissue lining the nonarticular surfaces of diarthrodial joints (12). Synovial tissues contain various types of cells, including type A cells, macrophage lineage cells, and type B cells, which are ...
10