TGF-β signaling
CCT6A suppresses SMAD2 and promotes prometastatic TGF β signaling
... of TGF-β signaling in cancer are far more complex than was previously understood, and these effects may be more cancer type and biologi- cal context dependent than ...to TGF-β ...
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Loss of TGF β signaling contributes to autoimmune pancreatitis
... of TGF-β signaling leads to the presentation of autoantigens by these aberrantly expressed MHC class II molecules, thereby initiating the increased pro- duction of this array of cytokines and ...
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Smad4-mediated TGF-β signaling in tumorigenesis
... of TGF-β signaling in the initiation and pro- gression of these diseases is not as explicit as in pan- creatic and colorectal ...of TGF-β without defined mutations or deletions of the ...
8
DHEA-induced ovarian hyperfibrosis is mediated by TGF-β signaling pathway
... by TGF-β sig- naling, while TGF-βRI inhibitors attenuated fibrogenic response by suppressing the elevation of TGF-β and Smad3 ...via TGF-β ...with TGF-βRI in- ...
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The Importance of Controlling the TGF-β Signaling Pathway in the Gastric Cancer Microenvironment
... the TGF-β pathway contributes to the generation of a favorable microenvironment for tumor growth and metastasis throughout the steps of ...effects, TGF-β induces the epithelial-to-mesenchymal ...
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Original Article Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation
... and TGF-β-mediated regulation of Th17 differ- entiation remain ...of TGF-β and IL-6 (IL-6/ TGF-β) signaling can directly mediate the degra- dation of FOXP3 ...
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Disruption of TGF β signaling in T cells accelerates atherosclerosis
... them, TGF-β has been implied in atherosclerosis, but its mechanism of action remains ...negative TGF-β receptor II in T ...disrupted TGF-β signaling in T cells exhibited a ...
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Deficiency in neuronal TGF β signaling promotes neurodegeneration and Alzheimer’s pathology
... BDNF signaling rescues this neuronal cell death ...decreased TGF-β signal- ing does not involve increased production of hAPP, decreased lev- els of the Aβ-degrading enzymes neprilysin and IDE (32, ...
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BARD1 mediates TGF-β signaling in pulmonary fibrosis
... to TGF- β ...BARD1 β are upregulated in epithelial A549 ...BARD1 β at 48h whereas FL BARD1 is only weakly ...BARD1 β overexpression in A549 ...BARD1 β ( β ) expressing ...
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Angiotensin II–dependent TGF β signaling contributes to Loeys Dietz syndrome vascular pathogenesis
... the TGF-β pathway in aortic aneu- rysm. Upon TGF-β ligand binding to TβRII, TβRI (also known as ALK5) is recruited to and phosphorylated by ...propagates signaling through ...
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Non-degradative ubiquitination in Smad-dependent TGF-β signaling
... of TGF-b signaling through various ...to TGF-b, and what is structural basis for poly-ubiquitin chains to enhance Smad complex formation? It is also unclear what makes Smad2 such a poor substrate for ...
5
Role of TGF-β signaling in uterine carcinosarcoma
... In keeping with the biphasic nature of UCS [33, 34], these cell lines though predominantly sarcomatous reportedly express epithelial components [35]. Clinically, the epithelial component of USC is usually immunoreactive ...
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Role of TGF-β signaling in inherited and acquired myopathies
... the TGF-b branch ...MAPK signaling pathway in Smad- dependent and -independent mechanisms [16-18], and to inhibit the Akt/TORC1/p70S6K signaling pathway [19] (Figure ...
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Role of TGF-β signaling in tumorigenesis
... SnoN is also closely related homolog and has the two splice variant SnoA and SnoI isoforms found in human. SnoN and SnoA are expressed ubiquitously but SnoI is confined to malignant skeletal muscles [35]. SnoN and Ski ...
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Original Article Bioinformatics analysis of differentially expressed miRNAs in plasma of respiratory distress syndrome
... the key pathway involved in acute lung injury in mouse model [23]. Similarly, Chung C et al showed that the mammalian hippo kinases play crucial roles in surfactant homeostasis and coordination of peripheral lung ...
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Transforming Growth Factor – β and Glioma
... to TGF-β molecules which prevent them from binding to the actual receptors on the cell ...the TGF-β signaling pathway along with enhanced natural killer (NK) cell activity against ...
5
Effect of canonical NF-κB signaling pathway on the differentiation of rat dental epithelial stem cells
... FGF signaling pathway is upregu- lated or mice with loss of function of sprouty genes ...the TGF-β signaling pathway, can prolong the maintenance of the cervical loop and crown development ...
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TGF-β signal rewiring sustains epithelial-mesenchymal transition of circulating tumor cells in prostate cancer xenograft hosts
... between TGF-β and other signaling collaborators in cancer ...this TGF-β- mediated network can be deregulated through a dominant- negative effect via genome-editing of its cognate ...
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Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-β/SMAD signaling
... controlling TGF-β signaling and breast cancer cell invasion and ...of TGF-β, which promotes invasion and metastasis ...the TGF-β signaling pathway is considered a ...
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Role for TGF-β superfamily signaling in telencephalic GABAergic neuron development
... for TGF-β signaling in dorsal forebrain ...BMP signaling in the dorsal telencephalon is also suggested by the conditional mutation of BMP receptors, which results in loss of the choroid plexus ...
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