TGF-β1-induced EMT
MiR-487a Promotes TGF-β1-induced EMT, the Migration and Invasion of Breast Cancer Cells by Directly Targeting MAGI2
... factor β1 (TGF-β1) significantly increased the expression of miR-487a in MCF-7 and MDA-MB-231 breast cancer ...and TGF-β1 induced the in- creased miR-487a promoter activity via ...
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YY1 mediates TGF-β1-induced EMT and pro-fibrogenesis in alveolar epithelial cells
... during EMT of AECs. TGF- β -induced activation of the pro-fibrotic program was applied to determine the role YY1 may play in pro-fibrogenesis of type II alveolar epithelial ...with EMT and ...
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Original Article UBE2T silencing inhibits TGF-β1-induced epithelial-to-mesenchymal transition in colon cancer cells
... the EMT process, epithelial cells acquire fibroblast-like proper- ties and exhibit reduced intercellular adhesion and increased motility ...as TGF-β, hypoxia and IL-6 can upregulate Snail and therefore ...
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Oleanolic acid attenuates TGF β1 induced epithelial mesenchymal transition in NRK 52E cells
... on TGF- β 1-induced EMT in NRK-52E cells To determine whether OA suppressed TGF-β1-induced EMT in NRK-52E cells, we studied the cells morphology by Phase-contrast ...
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Traditional Chinese medicine formulation Yanggan Jiedu Sanjie inhibits TGF β1 induced epithelial mesenchymal transition and metastatic potential in human hepatocarcinoma Bel 7402 cells
... to EMT [8, 45–47]. Snail is an EMT-related transcriptional repressor, which regulate the transcrip- tion of target genes, such as E-cadherin, and is related to cancer metastasis [24, ...for ...
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Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathway
... It has been reported that there are multiple mechanisms by which bufalin could exert its antimetastatic effect. HIF-1α has been reported to be involved in tumor migration and invasion by regulating EMT. However, ...
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Regulation of TGF-β1-Mediated Wnt/β-catenin Pathways Plays an Important Role in EMT-like Transformation Induced by Cadmium
... the EMT of RTEC [13-14], thus, it's very likely that the stimulating effect of Cd on RTEC proliferation is closely related to the activation of MF during chronic cadmium ...
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AEG-1/MTDH-activated autophagy enhances human malignant glioma susceptibility to TGF-β1-triggered epithelial-mesenchymal transition
... to TGF-β1-triggered epithelial-mesenchymal transition (EMT) through induction of ...autophagy. TGF-β1 induced autophagy and activated AEG-1 via Smad2/3 phosphorylation in ...
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TGF beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
... of TGF-β1 that best correlate with the extent of fibrosis and myofibroblast-like cell induction [5] and TGF-β1 continues to be regarded as the most impor- tant of the growth factors involved ...
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Distinct mechanisms of TGF β1–mediated epithelial to mesenchymal transition and metastasis during skin carcinogenesis
... overexpress TGF-b 1 but exhibit decreased expression of the TGF-b type II receptor ...of TGF-b 1 in keratinocytes expressing a dominant negative TGF-bRII (ΔbRII) in the ...expression, ...
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TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
... after EMT which could contribute to breakdown of basement membranes and facilitate migra- ...by TGF-β1 in parallel with changes in EMT markers ...but TGF-β1 induced MMP-2 ...
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Original Article MicroRNA-26a promotes epithelial mesenchymal transition in pleural mesothelial cells
... undergo EMT and this is regulated by miR-26a. We found that TGF-β1 treated PMC cells up-regulates miR- 26a expression inducing mesenchymal pheno- type transformation in ...and TGF-β1 ...
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TGF-β1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1β but not abrogated by corticosteroids
... These data suggest that corticosteroid have only a modest impact on TGFβ 1 -induced EMT. This finding is consistent with reports that while corticosteroid have proven to be very beneficial in treating ...
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synergistically increase PAI-1 expression in hepatic stellate cells of rats
... PAI-1 induced inflamamtion and firbosis mediate the destruction of tissues, and on the other hand PAI-1 is able to help the liver repair after liver injury ...
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Rapamycin Inhibits Transforming Growth Factor β1 Induced Fibrogenesis in Primary Human Lung Fibroblasts
... factor β1 (TGF-β1)-induced fibrogenesis in primary lung fibroblasts, and whether the effect of inhibition would occur through the mammalian target of rapamycin (mTOR) and its downstream p70S6K ...
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Human cytomegalovirus promotes the activation of TGF-β1 in human umbilical vein endothelial cells by MMP-2 after endothelial mesenchymal transition
... activated TGF-β1 decreased by 60% when the HUVECs were treated with GM6001 (p < ...activated TGF-β1 decreased by 9% when the HUVECs were treated with aprotinin (p > ...activated ...
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Blocking Smad7 restores TGF β1 signaling in chronic inflammatory bowel disease
... Purification of lamina propria mononuclear cells and mucosal tissue organ culture. Lamina propria mononu- clear cells (LPMCs) were prepared as described previ- ously (15–17). In some experiments, cells were imme- diately ...
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Transforming Growth Factor Beta 1 869T/C and 915G/C Polymorphisms and Risk of Autism Spectrum Disorders
... addition, TGF-β1 is a potent immunosuppressive cytokine as well as a crucial regulator in brain development ...that TGF-β1 protects the brain from neuronal degeneration during inflammation in ...
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GENE POLYMORPHISM OF TRANSFORMING GROWTH FACTOR BETA-1 (TGF-Β1) AND ITS LEVEL IN RHEUMATOID ARTHRITIS PATIENTS ASSOCIATED WITH OSTEOPOROSIS DISEASE
... factor TGF-β1 is a multifunctional cytokine that regulates cell growth, adhesion, and differentiation in a wide variety of cell ...of TGF-β1 are those associated with growth modulation, ...
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Activation of transforming growth factor β1and early atherosclerosis in systemic lupus erythematosus
... A variation of an ELISA format previously reported for detec- tion of active TGF-β 1 was employed [15,16]. Venous blood was collected without anticoagulant and 16 × 100 µl samples were immediately aliquoted into 2 ...
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