TGF-β1/Smad2
Original Article Interleukin-26 promotes the proliferation and activation of hepatic stellate cells to exacerbate liver fibrosis by the TGF-β1/Smad2 signaling pathway
... Abstract: Liver fibrosis is a wound-healing process of liver featured by the activation of hepatic stellate cells (HSCs) and the deposition of extra cellular matrix (ECM). Accumulating facts have suggested that ...
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Original Article Astragaloside effect on TGF-β1, SMAD2/3, and α-SMA expression in the kidney tissues of diabetic KKAy mice
... kidney. TGF-β/ SMAD signaling pathways activation increased α-SMA protein expression ...that TGF-β1, SMAD2/3, and α-SMA up-regulation and activation are impor- tant in renal fibrosis process ...
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TGF-β1 Increases Resistance of NIH/3T3 Fibroblasts Toward Apoptosis Through Activation of Smad2/3 and Erk1/2 Pathways
... Inhibiting Smad2/3 and Erk1/2 Pathways, but Not Akt To elucidate the relative contributions of Smad-dependent and Smad-independent TGF-β1-mediated intracellular signaling pathways in protection ...
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Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1
... of TGF‑β/smad pathway and EMT by binding to GREM1 We have already found that miR-137 was lowly expressed in CC cell, but the specific mechanism remains ...GREM1, TGF-β1, Smad2 and Smad3 ...
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Original Article Inhibition of the TGF-β/Smads signaling pathway attenuates pulmonary fibrosis and induces anti-proliferative effect on synovial fibroblasts in rheumatoid arthritis
... of TGF-β1, Smad2/ Smad3 and p-Smad2/Smad3 (diluted at 1:1000, Cell Signaling Technology, Boston, MA, USA), as well as anti-rat primary antibody of β-actin (diluted at 1:3000, Becton Dickinson, ...
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Original Article Effect of TGF-β/Smads signaling in patients with osteoarthritis and osteoarthritis rat model
... by TGF-β [22-24]. TGF-β has been proved to be treated as a potential therapeutic target of OA ...that TGF-β/Smad signaling pathway plays Figure 3. TGF-β1, Smad2, and Smad3 mRNA ...
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TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5
... hAPP/ TGF-β1 double transgenic mice [19]. It is suggested that TGF-β1 enhances the uptake of Aβ by ...of TGF-β1- SMAD2/3 signaling in peripheral macrophages reduces Aβ ...
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The expression of TGF β1, Smad3, phospho Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
... of TGF-β ligands and down- stream signaling mediators has been studied in many types of tumors, and the results are discordant ...of TGF-β signaling in the develop- ment and invasion of NFPAs has not been ...
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Relative roles of TGF-β and IGFBP-5 in idiopathic pulmonary fibrosis
... to TGF- β both in vitro and in vivo ...that TGF-β1-induced EMT is reversed by fibroblast growth factor-1, through ERK phosphorylation and Smad2 dephosphorylation ...inhibiting TGF-β ...
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The effect of transforming growth factor-β1 on nasopharyngeal carcinoma cells: insensitive to cell growth but functional to TGF-β/Smad pathway
... the TGF-β/Smad signaling function including defects in TGF-β receptors and/or downstream signal molecular Smad proteins is associated with tumor progression, and specific defects in this signalling pathway ...
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Label-free quantitative proteomics identifies transforming growth factor β1 (TGF-β1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells
... the TGF-β-mediated tran- scriptional activity ...of Smad2/3, HDAC1 and H3K14ac to the promoter of PPARγ upon treatment with ...that Smad2/3, HDAC1 and H3K14ac constitutively bound to the PPARγ ...
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Original Article Smad2 and Smad3 play differential roles in the regulation of matrix deposition-related enzymes in renal mesangial cells
... and Smad2 or between MT1- MMP and Smad2 [29, ...that Smad2 is essential for the down-regulation of MMP-2 and MT1-MMP in response to TGF-β1 in ...MMP, TGF-β1 treatment for ...
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Distinct mechanisms of TGF β1–mediated epithelial to mesenchymal transition and metastasis during skin carcinogenesis
... dominant-negative TGF-βRII; AK, actinic keratosis; CIS, carcinoma in situ; DMBA, dimethylbenzanthracene; EMT, epithelial- to-mesenchymal transition; Jag1, Jagged 1; K14, keratin 14; ML, mouse loricrin promot- er; ...
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T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer
... of TGF-β1 are also associated with T cell dysfunction in cancer patients where it is a negative prognostic ...indicator[26]. TGF-β is a family of three isoforms comprising TGF-β1, 2 and ...
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Matrine Suppresses Pancreatic Fibrosis by Regulating TGF β/Smad Signaling in Rats
... the TGF-β/ Smad pathway in pancreatic ...of TGF-β1, α-smooth muscle actin (α-SMA), and collagen I in pancreatic tissues was assessed by immunohistochemical ...of TGF-β receptor 1 (TβR1), TβR2, ...
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TGF beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
... including TGF-β1 [3]. Thus, one possible role of TGF-β1 in IPF is to induce or promote epithelial cells in injured alveolar epithelium to undergo EMT [15], as is evi- dent from studies of ...
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GENE POLYMORPHISM OF TRANSFORMING GROWTH FACTOR BETA-1 (TGF-Β1) AND ITS LEVEL IN RHEUMATOID ARTHRITIS PATIENTS ASSOCIATED WITH OSTEOPOROSIS DISEASE
... that TGF-β1 gene not associated with development of osteoporosis in single form but found in association in combined form with Interleukin-10 (IL-10) ...T/C869 TGF-β1 gene polymorphism with ...
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Blocking Smad7 restores TGF β1 signaling in chronic inflammatory bowel disease
... of TGF- β 1 signaling, is overex- pressed in inflammatory bowel disease (IBD) mucosa and purified mucosal T ...exogenous TGF- β 1. TGF- β 1 cannot inhibit proinflammatory cytokine production in ...
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Transforming Growth Factor Beta 1 869T/C and 915G/C Polymorphisms and Risk of Autism Spectrum Disorders
... human TGF-β1 gene, located on chromosome ...control TGF-β1 serum ...affect TGF-β1 ...the TGF-β1 gene at positions 869 T/C and 915 G/C were analyzed to determine the ...
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Naringenin prevents TGF β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation
... of TGF-β1 is due to blocking the transport of TGF-β1 from the TGN to the plasma mem- ...and TGF-β1 by ...of TGF-β1, indicating that more TGF-β1 was ...
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