TGF-β1-Smad2 pathway
Original Article Cross-talk between TGF-β/Smad pathway and Wnt/β-catenin pathway in pathological scar formation
... Abstract: TGF-β1 is a key factor in the process of wound healing, which is regulated by TGF-β/Smad ...that TGF-β1 contributed to pathological scar ...Wnt/β-catenin pathway might ...
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Original Article Dexmedetomidine pretreatment alleviates cerebral ischemia-reperfusion injury in rats through resisting oxidative damage and regulating TGF-β1/Smad2/3 signaling pathway
... signaling pathway are involved in I/R ...regulating TGF-β1/Smad2/3 signaling ...and TGF-β1 and phosphorylated Smad2/3 (p-Smad2/3) protein expression were ...and ...
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Original Article Effect of TGF-β/Smads signaling in patients with osteoarthritis and osteoarthritis rat model
... present. TGF-β is a known inflam- matory factor that plays a critical role in a vari- ety of inflammation and related diseases [11, ...12]. TGF-β trimer can form tetramer with intra- cellular Smad2 ...
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Matrine Suppresses Pancreatic Fibrosis by Regulating TGF β/Smad Signaling in Rats
... the TGF-β/ Smad pathway in pancreatic ...of TGF-β1, α-smooth muscle actin (α-SMA), and collagen I in pancreatic tissues was assessed by immunohistochemical ...of TGF-β receptor 1 ...
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The effect of transforming growth factor-β1 on nasopharyngeal carcinoma cells: insensitive to cell growth but functional to TGF-β/Smad pathway
... the TGF-β/Smad signaling function including defects in TGF-β receptors and/or downstream signal molecular Smad proteins is associated with tumor progression, and specific defects in this signalling ...
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The expression of TGF β1, Smad3, phospho Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
... of TGF-β ligands and down- stream signaling mediators has been studied in many types of tumors, and the results are discordant ...of TGF-β signaling in the develop- ment and invasion of NFPAs has not been ...
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TGF beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
... including TGF-β1 [3]. Thus, one possible role of TGF-β1 in IPF is to induce or promote epithelial cells in injured alveolar epithelium to undergo EMT [15], as is evi- dent from studies of ...
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TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5
... hAPP/ TGF-β1 double transgenic mice [19]. It is suggested that TGF-β1 enhances the uptake of Aβ by ...of TGF-β1- SMAD2/3 signaling in peripheral macrophages reduces Aβ ...
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Original Article Smad2 and Smad3 play differential roles in the regulation of matrix deposition-related enzymes in renal mesangial cells
... of TGF-β-Smad signaling pathway in the regulation of mesangial matrix ...degradation. TGF-β1 mediates mesangial matrix deposition by stimulating ECM production while inhibiting its degradation ...
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Original Article Astragaloside effect on TGF-β1, SMAD2/3, and α-SMA expression in the kidney tissues of diabetic KKAy mice
... kidney. TGF-β/ SMAD signaling pathways activation increased α-SMA protein expression ...that TGF-β1, SMAD2/3, and α-SMA up-regulation and activation are impor- tant in renal fibrosis process ...
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Original Article Interleukin-26 promotes the proliferation and activation of hepatic stellate cells to exacerbate liver fibrosis by the TGF-β1/Smad2 signaling pathway
... Total protein was extracted with RIPA lysis buf- fer (Thermo Fisher Scientific, Waltham, MA, USA), according to the manufacturers’ proto- cols. The concentration of protein was deter- mined by DC protein assay (Bio-Rad, ...
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Original Article Inhibition of the TGF-β/Smads signaling pathway attenuates pulmonary fibrosis and induces anti-proliferative effect on synovial fibroblasts in rheumatoid arthritis
... signaling pathway influences rheumatoid arthritis (RA)-associated pulmonary fibrosis (PF) and proliferation of RA synovial fibroblast ...of TGF-β1 in RA + PF patients, RA patients and healthy ...
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Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1
... of TGF‑β/smad pathway and EMT by binding to GREM1 We have already found that miR-137 was lowly expressed in CC cell, but the specific mechanism remains ...GREM1, TGF-β1, Smad2 and Smad3 ...
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TGF β1–induced expression of human Mdm2 correlates with late stage metastatic breast cancer
... aggressive. TGF-β1 can also influence cell ...by TGF-β1 was halted when combined with the Hdm2 antagonist, ...to TGF-β1 as seen in the tumor microenvironment may elicit p53 ...
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Human cytomegalovirus promotes the activation of TGF-β1 in human umbilical vein endothelial cells by MMP-2 after endothelial mesenchymal transition
... A logarithmic increase in the number of progeny viruses was observed in the supernatants and HELF cells, which indicated that HELF supports the proliferative infection HCMV TR (Fig. 1A). Human umbilical vein endothelial ...
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A Search for Genes Mediating the Growth-Promoting Function of TGFβ in the Drosophila melanogaster Wing Disc
... (HSW) pathway, a molecular device that translates, through the activity of the Yorkie transcription coactivator, molecular forces within the epithelium into the regulation of both cell cycle progression and ...
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Original Article TGF-β promotes invasion and angiogenesis of oral squamous cell carcinoma SCC9 cells by upregulation of slug signal
... 5. TGF-β1-induced Slug through activation of VEGF promotes angio- ...Mock-CM, TGF-β1 cDNA, or VEGF siRNA was quantified for the numerical value of the product of the relative tube length and ...
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Effect of canonical NF-κB signaling pathway on the differentiation of rat dental epithelial stem cells
... signaling pathway is ...signaling pathway participated in many physiological and pathological processes such as cell proliferation, differentiation, apoptosis, inflammation, and immune response by ...
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Original Article DIM attenuates TGF-β1-induced myofibroblast differentiation in neonatal rat cardiac fibroblasts
... diac hypertrophy and fibrosis. Cardiac hypertro- phy and fibrosis induced by pressure overload in mice was attenuated by DIM, which could contribute to the activation of 5’-adenosine monphosphate-activated protein ...
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GENE POLYMORPHISM OF TRANSFORMING GROWTH FACTOR BETA-1 (TGF-Β1) AND ITS LEVEL IN RHEUMATOID ARTHRITIS PATIENTS ASSOCIATED WITH OSTEOPOROSIS DISEASE
... The results for continuous variables were expressed as means± SD. The means of the three genotype groups were compared in a one- way analysis of variance (ANOVA). Genotype frequencies in RA cases and control were tested ...
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