Th, helper T cells
Effective antigen presentation to helper T cells by human eosinophils
... and Th cells, proliferation was compared in cultures containing each cell type alone or together, with or without antigen pulsing (Figure ...and Th cells were added, and, strikingly, these ...
20
Abnormal CD4 + T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection
... Tfh cells is associated with HCV infection but not type III asymptomatic MC Tfh cells (CXCR5 + CD4+ T cells), a major subset of ef- fector CD4 + T cells, are associated with the ...
13
Individual T helper cells have a quantitative cytokine memory
... individual Th cells over time without resorting to genetic ...stimulation, T cells made a stable decision whether to produce a given cytokine or ...Th1 cells that was memorized for at ...
71
A multidrug resistance protein (MRP) like transmembrane pump is highly expressed by resting murine T helper (Th) 2, but not Th1 cells, and is induced to equal expression levels in Th1 and Th2 cells after antigenic stimulation in vivo
... murine T helper (Th) 2, but not Th1 lymphocyte cell clones, as revealed by extrusion of a fluorescent ...Th1 cells by antigenic stimula- tion in vitro leading to equal expression in activated ...
9
Biochemical basis of synergy between antigen and T helper (Th) cell mediated activation of resting human B cells
... either Th cells or rIL-4 in CD23 expression, while under no experimental condition does increasing B cell [Ca2+]i with ionomycin enhance CD23 ...B cells to respond more vigorously ...
9
The Newly Identified T Helper 22 Cells Lodge in Leukemia.
... malignant cells' biology in leukemia, investigators still lack a clear understanding of the role of non-malignant lymphocytes specially CD4 + T cells in the pathogenesis of ...patients, T ...
12
Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment
... the T helper (Th) cell differentiation pathway, which is expressed in T ...+ T cells from highly diverse inflammatory and malignant ...
12
Mercuric chloride, a chemical responsible for T helper cell (Th)2 mediated autoimmunity in brown Norway rats, directly triggers T cells to produce interleukin 4
... II T cells present in both ...purified T cells exposed to HgCl2 expressed high levels of IL-4 ...B cells was partly inhibited by anti-IL-4 mAb showing that IL-4 was ...other T ...
7
T helper cells as new players in ANCA associated vasculitides
... [4]. Th ey observed that ad- minis tration of anti-MPO antibodies hydrolyzed by the bacterial enzyme endoglycosidase S, which abolishes IgG binding to Fcγ receptors, attenuated both neutrophil infl ux and formation ...
9
Cytokines and T Helper Cells in Diabetic Nephropathy Pathogenesis
... Th22 cells, they produce IL-22 and differ from Th17 and Th1 cells due to their differentiation and ...Th22 cells in patients with DM1 [110] ...different Th cells profiles by flow ...
17
Enhanced IgG4 production by follicular helper 2 T cells and the involvement of follicular helper 1 T cells in the pathogenesis of IgG4 related disease
... + cells are increased in IgG4-RD [37, 50, ...Tfh1 cells and their activated phenotype was increased in patients with IgG4-RD compared to patients with pSS or MCD, or ...Tfh1 cells remains to be ...
14
Selective induction of rheumatoid factors by superantigens and human helper T cells
... human helper T cells and co-cultured them with purified B ...cognate T-B cell interaction, we have used bacterial superantigens that function by cross-linking HLA molecules on the B cell with ...
9
Plasma levels of monokine induced by interferon-gamma/chemokine (C-X-X motif) ligand 9, thymus and activation-regulated chemokine/chemokine (C-C motif) ligand 17 in children with Kawasaki disease
... Th2 cells, the significant increasing of plasma levels of MIG/CXCL9 and TARC/CCL17 in KD patients should be an indication that Th1 and Th2 cells are activated and are positively associated with the ...
6
Disrupted balance of CD4+ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia
... pharmacological T-cell-activating agents that mimicked signals generated by T-cell receptor (TCR) complex and had the advantage of stimulating T cells of any antigen ...the cells. After ...
17
Role of T Follicular Helper cells in Multiple Sclerosis
... CD4 T cells, myelin antigen-reactive T cells from RRMS patients showed enhanced production of IFN-γ, IL-17, and GM-CSF compared to control subjects, while those from control subjects produced ...
5
TH 17 cells in rheumatoid arthritis
... of TH-17 cells in RA SF, and demonstrate that the abundance of TH-17 cells is significantly increased compared with RA or normal ...of TH-17 cells following short-term activation ...
7
CD57+ T-cells are a subpopulation of T-follicular helper cells in nodular lymphocyte predominant Hodgkin lymphoma
... other T helper subpopulations by co-expression of the TFH cell associated transcription factors c-Maf and BCL-6 in addition to expression of PD-1, CXCR5, CXCL13 and ICOS ...CD57+ T-cells [4] ...
5
Searching for the origin of the enigmatic circulating T follicular helper cells
... that correlated with transcription, and evi- dence of tonsillar GC Tfh cell signature in both. Importantly, chromatin regions of genes associated with Tfh cell function, such as IL-21 or CXCL13, were more acces- sible in ...
5
T follicular helper cells in patients with acute schistosomiasis
... mononuclear cells (PBMCs) were col- lected and isolated by Ficoll-density gradient centrifuga- ...Tfh cells: CD4-PE, ICOS-FITC (eBioscience, San Diego, CA,USA), CXCR5-APC and PD-1 PE-Cy7 (BioLegend, San ...
8
HIV and T follicular helper cells: a dangerous relationship
... TFH cells extracted from HIV-infected individuals expressed more BCL-6 — the transcription factor required for TFH formation and maintenance (19) — than those from treat- ed or uninfected subjects (4) (Figure 1, ...
5