The DNA damage response pathway
Genetic Interactions of the Aspergillus nidulans atmAATM Homolog With Different Components of the DNA Damage Response Pathway
... the DNA damage response in eukaryotic ...the DNA damage response, we found that AtmA is also required for polarized hyphal ...the DNA damage response ...
17
Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma
... the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma Enrico Derenzini 1 , Claudio Agostinelli 2 , Enrica Imbrogno 1 , Ilaria Iacobucci 1 , Beatrice ...
17
Genetic and Physical Interactions Between DPB11 and DDC1 in the Yeast DNA Damage Response Pathway
... for DNA replication and S/M checkpoint control in Saccharomyces ...a DNA damage checkpoint protein, which, together with Mec3 and Rad17, has been proposed to form a PCNA-like complex and acts ...
10
Similar incidence of DNA damage response pathway alterations between clinically localized and metastatic prostate cancer
... DDR pathway has been reported to be altered in the 30% range in men with ...DDR pathway mutations or copy number alterations was 33% in three publically available ...DDR pathway al- terations is ...
6
Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway
... more rarely, T-cells. It is also known for close association with Epstein-Barr virus (EBV) which manifests a type II latent pattern [3]. EBV life cycle includes latent and lytic phase. During latent period, only a few ...
13
The constitutive activation of the DNA damage response pathway is a novel therapeutic target in aggressive B-cell lymphoma
... affect response to treatment and outcome, these findings raise questions and concerns about the potential applications of NGS technologies in clinical practice for outcome prediction and therapy selection ...
63
Original Article Ganoderma lucidum enhances carboplatin chemotherapy effect by inhibiting the DNA damage response pathway and stemness
... Received September 10, 2021; Accepted February 7, 2022; Epub March 15, 2022; Published March 30, 2022 Abstract: Inflammatory Breast Cancer (IBC) is a rare and aggressive type of breast cancer with a poor prognosis. Its ...
Sak and its potential role in the DNA damage response.
... and DNA damage ...in DNA damage pathways and found that full length wild-type Sak protein was found to be subjected to phosphorylation both in the presence and absence of ...key DNA ...
113
DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway
... interstrand DNA crosslinks ...downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous ...FA pathway and are synthetic lethal with DNA ...
10
Scorpins in the DNA Damage Response
... of DNA damage (left panel, top), RANBP9 protein shuttles between the nucleus and the ...Upon DNA damage such as IR and DNA-damaging drugs (left panel, bottom), ATM is activated and ...
24
Autophagy in DNA Damage Response
... autophagic pathway, called mitophagy (Figure ...in response to mitochondrial depolarization, these mitochondria are marked for degradation by ubiquitination of this mitochondrial protein by the E3 ligase ...
22
A Synthetic Circuit For Control Of The Bacterial Dna Damage Response Without Dna Damage
... SOS DNA damage response without a requirement for DNA ...SOS pathway activation independent of alternative processes that occur following DNA damage and RecA* ...NTD ...
135
The Smc complexes in DNA damage response
... mediate DNA repair are not ...their DNA repair functions are separ- able from their major functions in sister-chromatid cohesion and chromosome ...the DNA repair func- tions of the Smc complexes are ...
11
Ciliogenesis and the DNA damage response: A stressful relationship.
... to DNA damage and replication ...mediated DNA repair processes Localises to the basal body in the developing eye of mice where it promotes ...of DNA interstrand cross-links. Associated with ...
13
Role and Regulation of CIEBPa in Response to DNA Damage
... Although we have provided pharmacological evidence for the involvement of GSK3β in C/EBPα induction, we were not successful in providing the molecular evidence using siRNA targeting GSK3β. We were able to successfully ...
155
Roles of Ubiquitination and SUMOylation in DNA Damage Response
... repair pathway to resolve ICLR is also called FA pathway that mainly relies on HR but with distinct sets of nucleases and other DNA processing ...
26
DNA-PK suppresses a p53 independent apoptotic response to DNA damage
... or DNA-PK cs all showed a quantitatively equivalent and nearly complete rescue of apoptosis in a p53 null background implicate a direct role of the DNA-PK holoenzyme in the suppression of DNA ...
20
Nuclear Localization of p38 MAPK in Response to DNA Damage
... We show here that p38 MAPK translocates to the nucleus specifically upon activation by stimuli that induce DSBs, and that p38 MAPK nuclear trans- location is triggered by a conformational change in- duced by ...
10
Role of NEDD8 and neddylation dynamics in DNA damage response
... Enough evidences have been found to demonstrate the importance of Non-Cullin neddylation. For example, the number of non-Cullin neddylation substrates is still lim- ited and their functions still need to be further ...
11
DNA Damage Response in Hematopoietic Stem Cell Ageing
... p53-p21/PUMA pathway in HSC cell fate determination DNA damages exhaust HSCs in terms of self-renewal and differentiation by reducing the HSC pool (quantity) and com- promising HSC stemness (quality) ...
8