The Glyoxalase system
Dicarbonyl stress and dysfunction of the glyoxalase system in periodontal diseases
... Objective 5: To study the dicarbonyl proteome in the cytosol of hPDLFs incubated in low and high glucose in vitro Dysfunction of hPDLFs in dicarbonyl stress is mediated by protein modification by MG and related ...
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CULTIVAR-SPECIFIC EFFECT OF CADMIUM ON THE GLYOXALASE SYSTEM IN SOYBEAN (Glycine max)
... which glyoxalase system has an important ...on glyoxalase system and activity of enzyme glyoxalase І (GLO1) in roots and shoots of three soybean cultivars, which differ from each other ...
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Characterisation of glyoxalase 1 mutant mouse and glyoxalase 1 copy number alteration
... The glyoxalase system has an important protective role found throughout biological life. That is, to prevent the accumulation of MG and related dicarbonyls in cells and body fluids to levels that ...
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Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics
... nucleotide AGEs was associated with DNA strand breaks and mutagenesis [63]. Physiological consequences of dicarbonyl stress Where dicarbonyl stress occurs there is potential for increased cell dysfunction, detachment ...
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Progeny analysis of transgenic rice variety transformed with Glyoxalase I gene
... The glyoxalase system consists of two enzymes glyoxalase I and glyoxalase ...2013). Glyoxalase I first catalyses the formation of S-D lactogluthione from hemithiocetal which is formed ...
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Serum Magnesium, Manganese and Selenium in Diabetes Mellitus Patients and Their Association with Glyoxalase-1
... 2 Glyoxalase-1 and erythrocyte enzyme of the glyoxalase system catabolizes the methylgly- oxal is the main precursor of advanced glycation end prod- ucts ...
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Characterization of Toxoplasma gondii glyoxalase 1 and evaluation of inhibitory effects of curcumin on the enzyme and parasite cultures
... When a broad range of curcumin concentrations (1– 100 μM) was tested, the growth of T. gondii parasites was inhibited in a dose-dependent manner (Fig. 3c). The IC 50 of curcumin in T. gondii was 38.3 ± 0.9 μM. These ...
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Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease
... The biochemical function of GLO1 is the glutathione- dependent metabolism of the reactive dicarbonyl metabo- lites, glyoxal and MG, to glycolate and D-lactate respectively, in order to prevent irreversible protein ...
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Transcriptional control of glyoxalase 1 by Nrf2 provides a stress responsive defence against dicarbonyl glycation
... Nrf2 system does indeed serve to protect against MG-mediated nucleotide and protein damage in vivo (Figure 3J and ...The glyoxalase system is a detoxification system for endogenous acyclic ...
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Reappraisal of putative glyoxalase 1 deficient mouse and dicarbonyl stress on embryonic stem cells in vitro
... The aim of this study was to assess if the Lexicon Glo1 mutant mice were protected against dicarbonyl stress through an alternative fate of MG metabolism, or other mechanism. We therefore developed genotyping methodology ...
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Novel glyoxalase-I inhibitors possessing a “zinc-binding feature” as potential anticancer agents
... detoxifying glyoxalase system to minimize the intracellular concentrations of toxic ...the glyoxalase system (Glo-I and/or Glo-II) may be detrimental for cancer cells, potentially leading to ...
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Original Article Glyoxalase 1, regulated by LncRNA MALAT1, promotes malignant development of esophageal squamous cell carcinoma
... that Glyoxalase I (GLO1) was a potential downstream effector of ...the glyoxalase system, which encodes a ubiquitous detoxification pathway being implicated in the progression of multiple ...
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Glyoxalase 1 modulation in obesity and diabetes
... Clinical evaluation of glyoxalase 1 inducer, tRES-HESP The Glo1 inducer, tRES-HESP, was evaluated in a recent clinical study of healthy overweight and obese subjects. The study was a randomized, double blind, ...
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A GLYOXALASE-1 VARIANT ASSOCIATED WITH THE t-COMPLEX IN HOUSE MICE
... GLO- 1 phenotypes among progeny of various backcrosses did not provide any evidence that loci unlinked to the t-haplotype determined GLO- 1C (Table 3). T h e GLO-1 ph[r] ...
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Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal
... USA. Glyoxalase 1 (Glo1) expression has previously been associated with anxiety in mice; however, its role in anxi- ety is controversial, and the underlying mechanism is ...
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Alpha synuclein deficiency leads to increased glyoxalase I expression and glycation stress
... Received: 2 June 2010 / Revised: 20 July 2010 / Accepted: 28 July 2010 / Published online: 14 August 2010 Ó The Author(s) 2010. This article is published with open access at Springerlink.com Abstract The presynaptic ...
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Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Heart-Explant Derived Cell Dysfunction
... Conditioned medium was collected after 48 hours of culture within 5% oxygen and 1% exosome- free serum under physiological glucose conditions. EVs were isolated using ExoQuick-TC exosome precipitation solution ...
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Glyoxalase I Is Differentially Expressed in Cutaneous Neoplasms and Contributes to the Progression of Squamous Cell Carcinoma
... Consis- tently, the normal and control siRNA–treated cells proliferated more quickly compared with the GLO1 siRNA–treated cells, and the TRAIL stimulation sensitized the inhibition of ce[r] ...
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Improved glycemic control and vascular function in overweight and obese subjects by glyoxalase 1 inducer formulation
... extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91 phox. J Cell Biol 2001;154:879-891 51. Brouwers O, Niessen PMG, Miyata T, Ostergaard JA, ...
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Bioinformatics Study of the Sequence Analysis and Secondary Structure Prediction of Avicennia marina glyoxalase I protein
... that glyoxalase I salt stress plant family consists of higher percentage of α-helix structure as compared to salt sensitive plant glyoxalase ...marina glyoxalase I secondary structures, consists of ...
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