The HIV genome
Mapping Sites of Positive Selection and Amino Acid Diversification in the HIV Genome
... A safe and effective HIV-1 vaccine is urgently needed to control the worldwide AIDS epidemic. Traditional methods of vaccine development have been frustratingly slow, and it is becoming increasingly apparent that ...
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The biased nucleotide composition of the HIV genome: a constant factor in a highly variable virus
... summary, HIV-1 prefers, like other retroviruses and repeat elements such as Alu repeats, the open, active chromatin in GC-rich isochores for DNA integration, but being GC-poor the provirus may be somewhat un- ...
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Genome-Wide Association Study of HIV Whole Genome Sequences Validated using Drug Resistance
... the HIV genome, there are some ...at genome-wide significance, though given many were nominally significant, this is likely to reflect small sample ...dramatic genome-wide inflation in test ...
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APOBEC3 Has Not Left an Evolutionary Footprint on the HIV-1 Genome
... Vif-deficient HIV by G-to-A mutation; however, the roles of these enzymes in the evolution of HIV are ...the HIV genome in the form of (i) underrepresentation of hA3G/F target motifs ...
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APOBEC3G and APOBEC3F rarely co mutate the same HIV genome
... the HIV genome, referred to as ‘ hypermutation ’ ...full genome HIV-1 sequences from naturally infected patients to uniquely identify sequences hypermutated by either or both of these ...
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The SHAPE of tRNA folding and of the 5'-end of the HIV-1 genome
... THE HIV-1 GENOME 5.1 Introduction The HIV-1 RNA genome participates in multiple, pivotal, stages of the viral life ...The HIV genome represents a compelling target for antiviral ...
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An integrated map of HIV genome wide variation from a population perspective
... major HIV groups, subtypes and circulating recombinant forms (CRFs) were analyzed along with structural, immunological and peptide inhibitor ...of HIV genomes was almost 50% between HIV-1 and ...
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HIV genome-wide protein associations: a review of 30 years of research
... The HIV genome encodes a small number of viral proteins ...among HIV proteins and between HIV and host proteins, to invade host cells and hijack their internal ...the HIV envelope ...
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Within host and between host evolutionary rates across the HIV 1 genome
... the HIV genome, with higher rates in the envelope gene ...first genome-wide overview of the differences in the HIV rates of molecular evolution at the within- and between-host ...whole ...
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Exploitation of the Low Fidelity of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase and the Nucleotide Composition Bias in the HIV-1 Genome To Alter the Drug Resistance Development of HIV
... the HIV genome, which has been explained by dCTP pool imbalances during reverse ...of HIV-1 reverse transcriptase markedly enhances the genetic variation of HIV and may be responsible for the ...
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A whole genome screen for HIV restriction factors
... of use to determine which genes are enhanced in the presence or absence of PAF1 using gene array analysis. Conclusions In summary we describe the identification of 114 genes that are involved in restriction of HIV ...
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A Pan HIV Strategy for Complete Genome Sequencing
... increased HIV-1 reads (⬃10- to 50-fold) and genome coverage (from 28% to 54%), pre- sumably by decreasing human background nucleic acid, while a postextraction DNase treatment was often detrimental ...
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Identifying Recombination Hot Spots in the HIV-1 Genome
... of HIV-1 recombination using the marker method, with two marker configurations in gag and pol that allow recombination to be measured over 13 and 26 regions, ...the genome but varies with nucleotide posi- ...
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The therapeutic landscape of HIV-1 via genome editing
... in HIV+ Patients with Non‑ Hodgkin’s LymphomaTat ribozymeTat‑rev mRNANCT00002221Phase II completedRibozyome/City of Hope Inhibitory peptidesM87o autologous HSCs for HIV+ patients with malignant diseaseC46 ...
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Genome wide association studies on HIV susceptibility, pathogenesis and pharmacogenomics
... of HIV-1 infection and pathogenesis have been identified in the last decen- nia, either by the classical candidate-gene approaches or in the last four years with the help of ...in HIV-1 infection and dis- ...
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High throughput profiling of point mutations across the HIV 1 genome
... complete HIV-1 genome, we have identified a number of improvements that can be incorporated in the future usage of our ...the genome with the mutation of interest cre- ated an average RC value to be ...
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HIV 1 associated PKA acts as a cofactor for genome reverse transcription
... for HIV-1 genome reverse transcription Life cycle of ...RNA genome by the RT RNAse H activity during progres- sion of the reverse transcription ...
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Molecular characterization of HIV-1 genome in fission yeast Schizosaccharomyces pombe
... of HIV-1 rev was induced in a fission yeast strain carrying the pYZ1N-rev plasmid, and the level of ROS was subsequently detected in cells at 21, 24, and 30 h after rev gene induction ...of HIV-1 rev gene ...
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A whole genome association study of mother-to-child transmission of HIV in Malawi
... maternal HIV infection, a nested case control was conducted, focusing on infants of HIV positive ...were HIV-exposed, cases were defi ned as infants who became HIV positive at birth, 6 weeks, ...
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Proviral HIV-genome-wide and pol-gene specific Zinc Finger Nucleases: Usability for targeted HIV gene therapy
... and HIV-1 whole genome specific zinc finger nucleases, which are proposed for use towards targeted HIV gene ...of HIV at evading previous therapeutic and vaccine attempts, we - building on the ...
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