The integrated stress response
eIF2B bodies and their role in the integrated stress response
... 15 1. Introduction 1.1 General Introduction Different cell types exhibit distinct gene expression profiles which are rapidly modulated in response to internal and external stimuli. Genes are transcribed into mRNA ...
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Emerging role of the integrated stress response upon viral infection
... The integrated stress response (ISR) is an adaptational signaling pathway that is induced in response to different stimuli, such as accumulation of unfolded and misfolded protein, hypoxia, ...
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Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells
... this response is clearly separable from Smad7 activation and inhibition of TGFb signaling ...ATF4-mediated Integrated Stress Response (ISR) ...ER stress targets in our data, suggest ...
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The integrated stress response prevents demyelination by protecting oligodendrocytes against immune mediated damage
... In response to ER stress, the pancreatic endoplasmic reticulum kinase (PERK) coordinates an adaptive program known as the integrated stress response (ISR) by phosphorylating the α ...
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Cellular eIF2B subunit localisation: implications for the integrated stress response and its control by small molecule drugs
... the integrated stress response (ISR) via phosphorylation of eIF2α and the subsequent control of eukaryotic initiation factor 2B (eIF2B), a multisubunit guanine nucleo- tide exchange ...On ...
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Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4
... cellular response to stress, and apoptosis signalling among those showing enhanced ...an integrated stress response meditated by phosphorylation of eIF2 α via multiple kinases (PERK, ...
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Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction
... in response to persistent DNA damage remains ...the stress-responsive transcription factor ATF4 [ 26 , 28 ...the integrated stress response (ISR), ATF4 is a transcription factor that ...
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Dual role of the integrated stress response in medulloblastoma tumorigenesis
... We showed that GADD34 mutation, either heterozygous or homozygous, elevated the level of CHOP but did not change the level of p-eIF2α in medulloblastoma in adult Ptch1+/− mice. The elevation of p-eIF2α level is transient ...
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Novel Insights into the eif2 alpha Integrated Stress Response on Microbial Infection, Inflammation and Proteotoxic Stress
... 1.4 Rationale and Hypothesis Since the discovery of the ISR, its impact on a broad range of cellular processes has become increasingly apparent. Moreover, there is already evidence of interactions between the ISR and ...
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The integrated stress response regulates BMP signalling through effects on translation
... To define the effects of the ISR on more proximal read- outs of dpp signalling, we next examined MAD phosphor- ylation in pupal wings. During pupation, longitudinal veins are specified by epidermal growth factor receptor ...
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The Role of the Integrated Stress Response Kinase Gcn2 in Cell Cycle Regulation and Tumorigenesis
... 13 Project aims The goals of this project were two-fold. First, we wanted to characterize additional pathways downstream of GCN2 that promote cell survival under nutrient stress. For this, we focused on how GCN2 ...
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TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the integrated stress response
... during stress due to reduced initia- tion at the ...mediate stress resistance, it is unclear whether such a mechanism is plausible with- out additional factors ...most stress-resistant mRNAs possess ...
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Reovirus Induces and Benefits from an Integrated Cellular Stress Response
... Following infection with most reovirus strains, viral protein synthesis is robust, even when cellular trans- lation is inhibited. To gain further insight into pathways that regulate translation in reovirus-infected ...
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Sphingolipids: towards an integrated view of metabolism during the plant stress response
... in response to foliar ...in response to drought stress, the 516 relationship between sphingolipids and ABA in response to foliar pathogens remains to be 517 ...
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Integrated transcriptomic and proteomic analysis of the global response of Wolbachia to doxycycline-induced stress
... Our integrated transcriptomic and proteomic study has revealed that a 70-year-old drug with a well-defined target displays a plethora of effects on gene expression, even in a bacterium with a highly reduced ...
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iTAP: integrated transcriptomics and phenotype database for stress response of Escherichia coli and Saccharomyces cerevisiae
... and fold changes for each of the genes in Escherichia coli and Saccharomyces cerevisiae by comparing the gene expression of various strains against a reference strain as indicated in the corresponding publication. In ...
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Integrated Metabolomics and Transcriptomics Suggest the Global Metabolic Response to 2-Aminoacrylate Stress in Salmonella enterica
... metabolic stress. The accumulation of 2AA causes a cellular stress that is multipronged, yet subtle, since the activity of multiple enzymes is reduced by ...
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The Response to Stress
... acute stress actually improves our brain's attention and increases our capacity to store important and life-protecting information, for example, a source of danger, chronic stress dampens our ability to ...
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Integrated Stress Testing
... Scenario definition and associated risk measurement models must take into account all risk factors rather than a siloed risk type approach. The stress test must incorporate the impacts of one risk type on another. ...
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Response to Hyperosmotic Stress
... appropriate response and adaptation to hyperosmolarity, ...hyperosmotic stress, the yeast initiates a complex adaptive program that includes tem- porary arrest of cell-cycle progression, adjustment of ...
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