The interaction between p53 and APP expression/proteolysis
Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis
... tagged p53 proteins as bait, followed by an anti-GST antibody to detect the presence of bait ...bound p53-GST directly ...bind p53 directly and in this interaction, the Cys-rich and C-terminal ...
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Dissection of the functional interaction between p53 and the embryonic proto oncoprotein PAX3
... dependent transcription from the WAF1 promoter (p21luc, Fig. 1F). In contrast to the HDM2-P2 and BAX promoters, PAX3 over-expression caused a modest, but reproducible, up-regulation of WAF1 reporter activity in ...
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Prognostic implications and interaction of L1 methylation and p53 expression statuses in advanced gastric cancer
... of p53 group ...that p53 immunohistochemis- try is required for the application of L1 methylation status as a prognostic parameter in ...association between tumoral L1 hypomethylation and shortened ...
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Prognostic interaction between expression of p53 and estrogen receptor in patients with node negative breast cancer: results from IBCSG Trials VIII and IX
... assess p53 status have both advantages and ...of p53 activity in yeast offers a distinction between inactivating and other mutations ...of p53 inactivation, which can potentially be measured ...
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Prognostic interaction between expression of p53 and estrogen receptor in patients with node-negative breast cancer: results from IBCSG Trials VIII and IX
... comparison between immunohisto- chemical staining in morphological normal breast and invasive breast ...for p53 as described below was success- fully performed on TMAs from 1,113 patients (Trial VIII, 417; ...
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Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53
... TP expression, we also showed that p53 has a critical role in the observed ...in p53-null HCT-116 p53 − / − cells VPA still modulates both TS and TP, no synergistic antitumor effect was ...
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Complex interaction between dengue virus replication and expression of miRNA 133a
... miRNA-133a expression changes in response to DENV infection in DENV targets cells could provide very interesting clues about the host factors that are involved during DENV ...
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SpeakUp – A Mobile App Facilitating Audience Interaction
... student-teacher interaction during class is an important part of the learning ...interactions between speakers and audiences through anonymous messaging and a peer rating ...
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Interaction with a TV Companion App as Synopsis and Supplement
... difference between individuals. Each participant was then introduced to the SAOS app and its features were explained to them, including the twisty menus in the supplementary ...
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Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice
... Morris water maze Experiments were performed in a tank 180 cm in diam- eter and 50 cm deep, filled with opaque water main- tained at 21 °C, equipped with a platform of 18 cm in diameter, submerged 1 cm below the surface ...
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Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice
... using the ABC system (VECTASTAIN Elite ABC HRP Kit, Vector Laboratories, Burlingame, CA, USA). Horse- radish peroxidase conjugate and 3,3′-diaminobenzidine were then used according to the manufacturer’s manual (Vector® ...
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Relationship between proteolysis and water-holding of myofibrils
... * Corresponding author: E-mail address: [email protected] ** Co-corresponding author: E-mail address: [email protected] Abstract The purpose of this study was to increase the knowledge on the relationship ...
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p53 controls hpar1 function and expression
... wt p53 is expressed at 32 1C as compared to equal PAR1 levels at 37 1C (mt p53 is ...(H1299 p53/321C) as compared with cells incubated at 37 1C (H1299 ...wt p53 expression (H1299 ...
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The expression and significance of IDH1 and p53 in osteosarcoma
... mRNA expression of IDH-1, p53 and internal control geneβ-actin was quantified by Real-time PCR Detection System (SLAN, HONGSHI) with SYBR Green I (Toyobo, Osaka, ...for p53 7-8 ...
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Targeting the p53/MDM2 protein-protein interaction
... 3.15 Conclusions and Future Work This chapter explored the synthesis of novel chlorofusin analogues whilst maintaining the structure of the chlorofusin peptide. Despite simple bicyclic acids displaying no activity, the ...
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The Relationship between p53 Expression and Human Papillomavirus in Premalignant and Malignant Uterine Cervical Lesions
... of p53 protein immunoreactivity, a tumor sup- pressor gene ...the p53 oncoprotein, the most common cellular tumor suppressor gene product in human ...mutant p53 positivity rate was ...in p53 ...
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SPECIAL COMMUNICATION Evaluation of correlation between expression of P53 and Malondialdehyde levels in prostate cancer patients
... The p53 transcription factor is encoded by TP53 gene, located on chromosome ...The p53 gene and its encoded protein play a central role in regulating cell cycle progression, deoxyribonucleic acid (DNA) ...
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App Neutrality: Apple’s App Store and Freedom of Expression Online
... Finally, there is the role of the different sorts of pressure brought to bear on the app store approval process. While some might applaud Apple’s responsiveness to public opinion, the ease with which Apple can ...
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Histopathological Analysis and P53 Expression in Intestinal Tumors.
... the p53 gene is the most common genetic event in the sporadic small intestine ..., p53 inactivation commonly caused by mutation and allele loss has shown to play an important role in the early development ...
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Apoptosis and p53 expression in rat adjuvant arthritis
... increased expression of p53 in the joints of rats with chronic AA was even greater than that observed in synovial tissue of RA patients with long-standing ...of p53 and increased numbers of apoptotic ...
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