The intrinsic pathway
Targeting the Intrinsic Pathway of Coagulation with RNA Aptamers
... modestly increase VTE risk, and vice versa, thus supporting that these thrombotic disorders have different mechanisms (5). Venous thrombosis usually occurs with “red” clots in the large veins in the legs, where part or ...
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Synergistic Effects of Arsenic Trioxide and Radiation: Triggering the Intrinsic Pathway of Apoptosis
... Taken together, the findings of this study revealed that ATO in combination with IR more strongly increased the apoptosis progression in U87MG cells, which in turn results in the cell growth arrest and death. Therefore, ...
8
Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma
... the intrinsic pathway of apoptosis To further analyze Hox-C9-induced cell death, the expression of pro- and anti-apoptotic regulators was examined by immunoblot, qRT-PCR and microarray analysis in HOXC9- ...
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The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells
... activation and loss of mitochondrial membrane potential followed by ROS production, which are all events associated with the mitochondrial apoptotic pathway. Moreover, Jurkat cells deficient for caspase-9, the ...
12
Simian Varicella Virus Induces Apoptosis in Monkey Kidney Cells by the Intrinsic Pathway and Involves Downregulation of Bcl-2 Expression
... extrinsic pathway involves activa- tion of caspase-8 and is initiated by ligand interaction with Fas or death receptors, while the intrinsic pathway is activated by an imbalance between proapoptotic ...
10
Original Article Human cytomegalovirus impairs megakaryopoiesis by reducing c-Mpl expression and inducing apoptosis via the intrinsic pathway
... Received December 15, 2015; Accepted May 20, 2016; Epub May 1, 2017; Published May 15, 2017 Abstract: Background: Human cytomegalovirus (HCMV) is a frequent life-threatening infection of immunocompro- mised individuals. ...
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Intrinsic Pathway−Mediated Apoptosis in Elastase Induced Aneurysms in Rabbits
... and/or intrinsic pathway, both leading to a final common pathway in which activated downstream caspases are involved in DNA ...extrinsic pathway, known as the death- receptor pathway, ...
5
Acute Noise Exposure Is Associated With Intrinsic Apoptosis in Murine Central Auditory Pathway
... the intrinsic, mitochondrial apoptotic pathway seems to be particularly involved due to oxidative stress by generation of ROS (Ohlemiller et ...the intrinsic pathway was indicated by ...
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Induction of the intrinsic apoptotic pathway via a new antimitotic agent in an esophageal carcinoma cell line
... In this study, it was investigated whether ESE-16 is capable of inducing apoptosis in vitro in the esophageal carcinoma SNO cell line via the intrinsic pathway at a concentration of 0.2 μ M with an exposure ...
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Silica nanoparticle-induced oxidative stress and mitochondrial damage is followed by activation of intrinsic apoptosis pathway in glioblastoma cells
... Many reports on SiNP-mediated apoptosis demonstrate activation of the intrinsic pathway after NP exposure. 10–12 Indeed, Ahamed et al reported that treatment of A431 and A549 cells with SiNPs resulted in ...
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Role of intrinsic coagulation pathway in the pathogenesis of idiopathic pulmonary fibrosis
... of intrinsic coagulation components to the development of pulmonary ...the intrinsic coagulation cascade, has a capacity to drive fibrotic responses to lung injury, since knockout of FXII in mice or ...
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Requirement of Treg-intrinsic CTLA4/PKCη signaling pathway for suppressing tumor immunity
... this pathway in tumor ...signaling pathway might therefore represent a novel immunotherapeutic strategy to promote antitumor immunity while potentially preserving the ability of Tregs to maintain immune ...
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Hyperammonia induces specific liver injury through an intrinsic Ca2+-independent apoptosis pathway
... Roles of caspase-3, Cyt C, and bcl-2 in liver regeneration To examine whether hyperammonia induces liver injury through an apoptosis pathway, we examined the effects of NH 4 Cl on apoptosis by measuring the levels ...
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TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis
... mitochondrial intrinsic pathway of apoptosis did not undergo apoptosis when exposed to TRAIL but showed membrane blebbing, and a transient loss of adhesion ...
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Andrographolide potentiates the antitumor effect of topotecan in acute myeloid leukemia cells through an intrinsic apoptotic pathway
... metabolic pathway through which the combination of andrographolide and TP is inhibiting the cell proliferation of U937, Western blot analysis was performed to assess the expression of a series of proteins related ...
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Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.
... the intrinsic apoptotic ...the intrinsic apoptosis pathway via inhibition of Rho family prenylation and depletion of GGPP, in a variety of different human cancer cell ...
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<p>Evodiamine Selectively Inhibits Multiple Myeloma Cell Growth by Triggering Activation of Intrinsic Apoptosis Pathway</p>
... Malignant cells generally produce more mitochondria ROS than non-malignant cells to maintain redox homeosta- sis. In addition, antioxidant molecules and thioredoxin reduc- tase are upregulated in MM, which is correlated ...
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The Neuroprotective Effect of Sodium Nitrite on Ischemic Stroke-Induced Mitochondrial Dysfunction via Downregulation of Intrinsic Apoptosis Pathway
... We aimed to evaluate the effect of sodium nitrite (SN) on ischemic injury-induced mitochondrial damage and investigated the expression of Bcl-2 family proteins and mitochondrial vital[r] ...
7
Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathway
... and intrinsic signaling path- ways have to be differentiated ...aling pathway [12, ...The intrinsic signaling pathway is the cellular response to stress ...
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Intrinsic Differentiability and Intrinsic Regular Surfaces in Carnot groups
... uniform intrinsic differentiability, for maps acting between complementary subgroups of G ...is intrinsic differentiable if it is well approximated by appropriate linear type functions, denoted ...
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