The JAK/STAT signalling pathway
The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours
... the JAK/STAT signalling ...of JAK/STAT signalling in a network of signalling pathways whose deregulation contributes to cancer suggests that targeted inhibition of ...
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Manipulation of JAK/STAT Signalling by High-Risk HPVs: Potential Therapeutic Targets for HPV-Associated Malignancies
... the JAK/STAT signalling ...the JAK/STAT signalling ...for STAT proteins. JAK activation leads to the phosphorylation, dimerisation and activation of STAT ...
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Analysis of RNA Seq data reveals involvement of JAK/STAT signalling during leg regeneration in the cricket Gryllus bimaculatus
... the JAK/STAT signalling pathway were upregulated in blastemas, and that JAK/STAT signalling was essential for leg ...
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JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions
... canonical JAK/STAT signalling pathway Since the initial identification of a novel class of interferon- activated transcription factors over 14 years ago (Fu et ...the JAK/STAT ...
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Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway
... Drosophila JAK/STAT signalling pathway undertaken in the Sheffield RNAi Screening Facility ...of JAK/STAT signalling, 22 of which verified in a secondary screen and 16 ...
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Methotrexate Is a JAK/STAT Pathway Inhibitor
... suppresses JAK/STAT signalling and suggest that this suppression may explain the effectiveness of low-dose methotrexate treat- ments currently used as a first line treatment for inflammatory diseases ...
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Targeting SOCS proteins to control JAK-STAT signalling in disease
... and signalling Cytokines and cytokine-activated signalling pathways are central players in the development of autoimmune disorders (see Glossary), such as rheumatoid arthritis (RA), chronic inflammatory ...
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JAK/STAT Signalling in the Induction of the L-Arginine-Nitric Oxide Pathway in Macrophages and Vascular Smooth Muscle Cells
... NO pathway is potentially detrimental in the pathogenesis of chronic inflammation including sepsis and several other inflammatory ...the JAK/STAT ...of JAK/STAT signaling for iNOS ...
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miR 19a: an effective regulator of SOCS3 and enhancer of JAK STAT signalling
... Discussion Using KEGG database, InnateDB and TargetScan, we identified miR-19a sequence matches in the 3’UTRs of 12 JAK- STAT pathway proteins. We found that a miR-19a mimic significantly down ...
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JAK/STAT signalling mediates cell survival in response to tissue stress
... stress-response pathway promoting injury-induced apoptosis and compensatory ...single pathway. Signalling through the Janus kinase/Signal transducers and activators of transcription ...
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Essential role of endocytosis for Interleukin-4 receptor mediated JAK/STAT signalling
... IL-4R pathway activation, whereby endocytosis is an essential process upstream of receptor ...cortical signalling endosomes (CEs) and recycled to the plasma membrane, thus sampling the environment for ...
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Localised JAK/STAT Pathway Activation Is Required for Drosophila Wing Hinge Development
... of JAK/STAT pathway signalling in the process of wing hinge ...in JAK/STAT signalling within the proximal most of three lateral folds present in the wing imaginal disc is ...
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Linking energy sensing to suppression of JAK-STAT signalling: a potential route for repurposing AMPK activators?
... THE JAK-STAT PATHWAY Several agents have been developed that target the JAK-STAT pathway at multiple ...IL-6 signalling, the monoclonal anti-IL-6 antibody siltuximab [21], ...
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PI3K, p38 and JAK/STAT signalling in bronchial tissue from patients with asthma following allergen challenge
... The JAK pathway is activated by pro-inflammatory cytokines leading to phosphorylation of STAT transcription factors ...[3]. JAK/STAT signalling is essential for lymphocyte ...
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JAK/STAT signalling
... CHAPTER 5: Cross Talk to IFN G Rl OSM does not affect the kinetics of IFNy-induced STATl activation. This again suggests that downregulation of the OSM response occurs in cis rather than in trans. However, there is also ...
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Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application
... transcription) pathway plays a critical role in transduction of extracellular signals from cytokines and growth factors involved in hematopoiesis, immune regulation, fertility, lactation, growth and ...
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The JAK-STAT Pathway Is Critical in Ventilator-Induced Diaphragm Dysfunction
... that JAK–STAT affects the specific force of diaphragm muscle by both posttrans- lational modification (for example, ubiq- uitination, oxidation and nitration) of proteins, as well as by compromising the ...
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“Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway
... of JAK proteins. A BRIEF HISTORY JAK/STAT signaling cascade is among the highly conserved metazoan pathways observed in a wide range of species ( 23 ), which is involved in an array of cytokines and ...
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Modulation of human JAK-STAT pathway signaling by functionally conserved regulators
... with STAT-modulator phenotypes suggests that most siRNA pools are indeed ...both STAT phosphorylation and transcriptional activity have been widely used as proxies for pathway activity in the past, ...
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Feifukang ameliorates pulmonary fibrosis by inhibiting JAK STAT signaling pathway
... signaling pathway remains intractable because the potential targets and active substances of herbs are difficult to identify and analyze [37, ...including JAK-STAT family members (Jak, ...
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