The Mitotic Spindle
Kinetochore dynamics and their attachment to the mitotic spindle
... prometaphase, spindle poles are at opposite ends of the cell. The mitotic spindle searches for and captures chromosomes via kine- tochores, eventually aligning them at the metaphase ...
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Human asparagine synthetase associates with the mitotic spindle
... Relative expression of ASNS to alpha-tubulin is increased in cells treated with nocodazole and ASNase Given our finding that ASNS was localized to the mitotic spindle, we next explored the effect of ...
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Effect of SP600125 on the mitotic spindle in HeLa Cells, leading to mitotic arrest, endoreduplication and apoptosis
... disrupting agents provide a novel approach to cancer chemoprevention and/or cancer therapy. Recently, certain cancer chemotherapy agents have been found to exert their anticancer activities by disrupt- ing the dynamics ...
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Hsp72 is targeted to the mitotic spindle by Nek6 to promote K fiber assembly and mitotic progression
... the mitotic spindle is dependent on phosphorylation at Thr-66 within its nucleotide-binding domain by the Nek6 ...on spindle poles and sites of MT–kinetochore ...and mitotic progression that ...
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Regulated Assembly of the Mitotic Spindle: A Perspective from Two Ends
... the mitotic spindle apparatus. This mitotic spindle is composed of condensed chromosomes attached to a dynamic array of ...for spindle assembly and chromosome ...the spindle for ...
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FGFR3–TACC3 cancer gene fusions cause mitotic defects by removal of endogenous TACC3 from the mitotic spindle
... inducing mitotic defects in bladder cancer ...This mitotic mechanism occurs simultaneously with constitutive FGFR3–TACC3 sig- ...the mitotic spindle, and mitotic defects will still be ...
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Human Papillomavirus Oncoproteins E6 and E7 Independently Abrogate the Mitotic Spindle Checkpoint
... of mitotic checkpoint by ...the mitotic spindle checkpoint, normal human keratinocytes were infected with retroviruses express- ing HPV-16 E7 and neomycin-resistant colonies were pooled and ...the ...
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CiteSeerX — Electro-Acoustic Behavior of the Mitotic Spindle: A Semi-Classical Coarse-Grained Model
... the mitotic spindle vibrations. Such pulse excitation of the mitotic spindle generates strong electric field intensity at the centromere searching ends of ...
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The mitotic spindle protein SPAG5/Astrin connects to the Usher protein network postmitotically
... connecting cilium [13,14]. Thereby, NINL isoB may func- tion in the development and maintenance of the connect- ing cilium and outer segment [13]. In addition to NINL isoB , another centrosomal and microtubule-associated ...
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The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle
... compared mitotic progression in cells, where GFP-TACC3 expression was induced vs not ...in mitotic progression are similar to those seen following depletion of TACC3 (Lin et ...
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Loss of spatial control of the mitotic spindle apparatus in a Chlamydomonas reinhardtii mutant strain lacking basal bodies.
... In wild-type cells, migration of the centrosomes occurs in preprophase and prophase (GAFFEL and EL-GAMMEL. 1990); actin localizes mainly to the rootlets before centrosom[r] ...
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Mitotic Spindle Form and Function
... Duplicated side-by-side SPBs are observed upon the completion of SPB duplication. In this case, a complete bridge tethers the two SPBs, mother and daughter, together. SPB duplication can go to this late step in the ...
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INVESTIGATING MECHANISMS OF MITOTIC SPINDLE POSITIONING
... thinking to myself “that’s what I want to work on.” So, at the places I applied, I requested meetings with everyone working on C. elegans embryogenesis. Once I decided to go to graduate school at the University of North ...
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Transient defects of mitotic spindle geometry and chromosome segregation errors
... the mitotic spindle have a dramatic impact on chromosome ...the spindle defects are only transient. Indeed, whereas permanent spindle defects typically lead to cell death in the pro- geny, ...
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Mitotic spindle destabilization and genomic instability in Shwachman Diamond syndrome
... the mitotic spindle in control primary BMSCs, lymphoblasts, and skin fibroblasts and bound to purified ...increased mitotic abnormalities and aneuploidy that accumulated over ...increased ...
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Molecular pathways regulating mitotic spindle orientation in animal cells
... the mitotic spindle to influence its position prior to cell division ...as spindle-capture ...as spindle-capturing bait as well as force generators for the rapid spindle motions ...
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Plk2 regulates mitotic spindle orientation and mammary gland development
... the mitotic spindle in the mammary ...in spindle orientation in ductal luminal epithelial cells in ...proper mitotic spindle orientation are necessary to maintain the organization of ...
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Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix
... Aurora-A regulates the recruitment of TACC 3 to the mitotic spindle through a phospho-dependent interaction with clathrin heavy chain (CHC). Here, we describe the structural basis of these interactions, ...
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Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix
... Abstract Aurora-A regulates the recruitment of TACC 3 to the mitotic spindle through a phospho-dependent interaction with clathrin heavy chain (CHC). Here, we describe the structural basis of these ...
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Drosophila aPKC is required for mitotic spindle orientation during symmetric division of epithelial cells
... for mitotic spindle planar orientation Consistent with the mammalian tissue culture work (Durgan et ...for spindle orientation during symmetric ...of spindle positioning would potentially lead ...
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