The mucosal and systemic immune systems
Characterising the mucosal and systemic immune responses to experimental human hookworm infection
... The polarisation of the T cell response in hookworm infection is of some debate, with some studies showing a mixed Th1/Th2 response, while others report only a polarised Th2 response [12,26]. These conflicting results ...
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Enhanced mucosal and systemic immune responses to intestinal reovirus infection in beta2-microglobulin-deficient mice.
... in mucosal immunity to an enteric pathogen, we examined immune responses and viral clearance following enteric reovirus infection in C57BL/6, B6129F2, and b 2-microglobulin-deficient ( b 2m 2 / 2 ) ...
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Oral Immunization with Recombinant Norwalk Virus-Like Particles Induces a Systemic and Mucosal Immune Response in Mice
... an immune response and may be particularly useful as a mucosal ...a systemic or mucosal antibody response is notable, although CT did influence the magnitude of the IgG response at higher ...
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Chimeric Plant Virus Particles Administered Nasally or Orally Induce Systemic and Mucosal Immune Responses in Mice
... humoral immune responses to the D2 peptide of fibronectin-binding protein B (FnBP) of Staphylococcus aureus, expressed on the plant virus cowpea mosaic virus (CPMV), were evaluated after mucosal delivery to ...
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Comparison of mucosal and systemic humoral immune responses and subsequent protection in mice orally inoculated with a homologous or a heterologous rotavirus.
... To examine the correlation between the systemic immune response generated after live heterologous rotavirus infection and the subsequent protection against ECw challenge, we calculated a[r] ...
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Mucosal and Systemic Immune Responses Induced by Recombinant Lactobacillus spp. Expressing the Hemagglutinin of the Avian Influenza Virus H5N1
... The adhesion of a virus to the epithelium is essential for efficiently transferring avian influenza virus genes into cells, via a process that can be blocked by antibodies binding to HA proteins. HA is usually cleaved ...
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Immune Responses to the Microbiota at the Intestinal Mucosal Surface
... intestinal mucosal surface is a critical first line of host defense that is key for main- taining a symbiotic relationship with the intestinal ...the mucosal surface, and by coupling bacterial sensing to ...
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Plasminogen mediates communication between the peripheral and central immune systems during systemic immune challenge with lipopolysaccharide
... Plasminogen (PLG) and its active form, serine pro- tease plasmin, are blood proteins that play roles in fi- brinolysis, wound healing, cell signaling, extracellular matrix degradation, and inflammatory regulation [6]. ...
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Recombinant Norwalk Virus-Like Particles Administered Intranasally to Mice Induce Systemic and Mucosal (Fecal and Vaginal) Immune Responses
... a mucosal adjuvant by evaluating the immune responses to two soluble proteins, keyhole limpet hemocyanin and chicken egg ...candidate mucosal vaccine for NV infections in ...
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The intranasal adjuvant Endocine™ enhances both systemic and mucosal immune responses in aged mice immunized with influenza antigen
... protective immune responses in this age group, new vaccines strategies, such as the use of adjuvants, are ...the mucosal vaccine adjuvant Endocine ™ , formulated with split influenza antigen and ...
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Oral Immunization with Recombinant Lactobacillus acidophilus Expressing the Adhesin Hp0410 of Helicobacter pylori Induces Mucosal and Systemic Immune Responses
... In this study, our main objective was to develop an effective vaccine against H. pylori using Hp0410 as the antigen and L. aci- dophilus as the antigen delivery system. Our study showed that mucosal immune ...
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Comparison of Systemic and Mucosal Immunization withHelper-Dependent Adenoviruses for Vaccination against Mucosal Challenge with SHIV
... at mucosal surfaces during sexual ...at mucosal surfaces may mediate better protection against HIV-1 than vaccines that are delivered ...the systemic route generated stronger systemic CD8 T ...
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Systemic, Mucosal, and Heterotypic Immune Induction in Mice Inoculated with Venezuelan Equine Encephalitis Replicons Expressing Norwalk Virus-Like Particles
... and mucosal immune responses to NLV capsid ...a mucosal response to localized areas of ...tective immune response. The development of such systems and the design of innovative human ...
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Divergent HIV-1-Directed Immune Responses Generated by Systemic and Mucosal Immunization with Replicating Single-Cycle Adenoviruses in Rhesus Macaques
... These measurements were made from rectal samples 2 weeks after a second protein boost, a time when immune cells are presumably in a highly activated state. Exposure to HIV at such a time point might increase the ...
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Mucosal immune responses following intestinal nematode infection
... the mucosal surface that result in parasite expulsion or permit the establishment of chronic infections with luminal dwelling adult ...adaptive immune mechanisms that provide immune protection ...
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Intestinal bacterial biofilms modulate mucosal immune responses
... enhanced mucosal association of pathobionts and aberrant stimulation of mucosal ...to mucosal surfaces, biofilm components also stimulate immune responses and can therefore instigate or ...
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Interaction between the gut microbiome and mucosal immune system
... and mucosal immunity con- stantly interact to achieve intestinal ...intestinal immune system will trigger a variety of dis- eases, such as ...adaptive immune response that increased IBD inflammation ...
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Immune Profiling of Systemic Lupus Erythematosus
... of immune complexes containing TLR- binding self ...promote immune dysregulation in patients with ...particular immune process driving the ...
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Rectal Immunization with Rotavirus Virus-Like Particles Induces Systemic and Mucosal Humoral Immune Responses and Protects Mice against Rotavirus Infection
... an immune response to and protection from RV via the rectal route, proper adjuvants were manda- ...other mucosal routes in adult BALB/c mice might be due to the properties of sampling cells (M cells) or of ...
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Mucosal and Systemic Immune Responses to a Human Immunodeficiency Virus Type 1 Epitope Induced upon Vaginal Infection with a Recombinant Influenza A Virus
... cellular immune responses in the genital mucosa likely play an important role in the prevention of sexually transmitted infections, including infection with human immunodeficiency virus type 1 ...specific ...
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