The N-terminal Domain
Biochemical analysis of the N-terminal domain of human RAD54B
... an N-terminal region of 300 amino acid ...the N-terminal region of RAD54B may also be essential for the interac- tions with other recombination ...the N-terminal region of ...
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Structure and Function of the N-Terminal Domain of the Vesicular Stomatitis Virus RNA Polymerase
... the N-terminal domain of the polymerase that is essential to viral transcription and that shares sequence homology with members of the paramyxoviruses and the ...
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Solid-state NMR sequential assignments of the N-terminal domain of HpDnaB helicase
... Abstract We present solid-state NMR assignments of the N-terminal domain of the DnaB helicase from Helicobacter pylori (153 residues) in its microcrystalline form. We use a sequential resonance ...
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Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain
... Δ N-YFP lacking the N-terminal domain forms no dimers and only marginally affects the activity of ...the N-terminal domain of STAT3-YF plays an important role for the ...
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Ribonucleocapsid Formation of Severe Acute Respiratory Syndrome Coronavirus through Molecular Action of the N-Terminal Domain of N Protein
... The N-terminal domain of coronaviral N proteins (N-NTD) provides a scaffold for RNA binding, while the C-terminal domain (N-CTD) mainly acts as oligomerization ...
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Identification of the N-Terminal Domain of the Influenza Virus PA Responsible for the Suppression of Host Protein Synthesis
... Responsible for the Suppression of Host Protein Synthesis Emily A. Desmet,* Kendra A. Bussey,* Raychel Stone, Toru Takimoto Department of Microbiology and Immunology, University of Rochester School of Medicine and ...
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Dissecting the Role of the N-Terminal Domain of Human Immunodeficiency Virus Integrase bytrans-Complementation Analysis
... the N-terminal zinc-binding domain, the catalytic core, and the C-terminal SH3 ...an N-terminal domain, provided in trans, can restore IN activity of a mutant lacking this ...
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Mutational Analysis of the N-Terminal Domain of Moloney Murine Leukemia Virus Capsid Protein
... the N to C terminus, the three mu- tants in the -hairpin had two- to fourfold-higher amounts of immature particles than WT, suggesting a defect in matura- ...
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Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target
... HCoV N-NTD exists among di fferent CoVs (Figure S6, Supporting ...CoV N protein binding to single-stranded ...HCoV-OC43 N-NTD, we modeled the structure of HCoV-OC43 N-NTD in an RNA-bound state ...
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Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2*
... Because of sequence conservation between humans and zebrafish, we reasoned that the zebrafish model could be used to test the functionality of the N-terminal domain of PC2 by a dominant negative ...
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Annexin A2 is SUMOylated on its N-terminal domain: Regulation by insulin
... Insulin, in addition to initiating metabolic responses, elicits major changes in the F-actin distribution [9,10]. Previous reports have suggested that the tyrosine phosphorylation of ANXA2 at Y24 is involved in the ...
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Oligomerization of Hantavirus Nucleocapsid Protein: Analysis of the N-Terminal Coiled-Coil Domain
... The N protein is the most abundant component of the virion; it encapsidates genomic RNA segments forming ribonucleoproteins and participates in genome transcription and replication as well as virus ...
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Multiple Functions of the Nonconserved N-Terminal Domain of Yeast TATA-Binding Protein
... ence in total RNA used for each assay. tions at these positions do not confer this phenotype. Despite the overlap of this surface with the regions previously implicated in interactions with TFIIA and and Brf1-interaction ...
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Pharmacological Profiling of Orthochirus scrobiculosus Toxin 1 Analogs with a Trimmed N-Terminal Domain
... the N-terminal domain of [Lys 16 ,Asp 20 ]-OSK1 results in marked changes in its pharmacological profile, in terms of both K ⫹ channel affinity and ...
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The Ancestral N-Terminal Domain of Big Defensins Drives Bacterially Triggered Assembly into Antimicrobial Nanonets
... C-terminal domain and a globular hydrophobic ancestral N-terminal ...hydrophobic domain lost during evolution toward ...ancestral N-terminal domain confers ...
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Crystal Structure of Classical Swine Fever Virus NS5B Reveals a Novel N-Terminal Domain
... The N-terminal region of pestivirus NS5B contains about 90 residues, with its function remaining ...the N-terminal region of pestivirus NS5B could contribute to proper folding and/or the ...
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The N-Terminal DNA-Binding Domain of Rad52 Promotes RAD51-Independent Recombination in Saccharomyces cerevisiae
... the N-terminal domain of Rad52 can perform type II telomere recombination in the absence of RAD59, al- though the recombination in the mutant is very ineffi- ...
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The N Terminal Membrane Spanning Domain of the Escherichia coli DNA Translocase FtsK Hexamerizes at Midcell
... The N-terminal membrane-spanning domain of FtsK is required for cell division, whereas the C-terminal domain is a fast double- stranded DNA (dsDNA) translocase that brings the ...
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Characterization of the Redox Transition of the XRCC1 N-Terminal Domain.
... total carbonate concentration, to calculate the equilibrium constant of the carbamate structural element. Peaks representing the amine and carbamate species for the calculation of the X1NTD oxidized carbimate adduct ...
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Retroviral retargeting by envelopes expressing an N-terminal binding domain.
... the N-terminal insertion of polypeptides able to bind either Ram-1 phosphate transporter (the first 208 amino acids of amphotropic murine leukemia virus surface protein) or epidermal growth factor receptor ...
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