The NLRP3 inflammasome
The role of the NLRP3 inflammasome in gout.
... the NLRP3 inflammasome, such as IL-18, must also be ...the NLRP3 inflammasome and it will be important to identify such pathways and understand their interaction with the NLRP3 ...
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Spotlight on the NLRP3 inflammasome pathway
... the NLRP3 inflammasome pathway NLRP3 deubiquitination by the BRCA1/BRCA2-containing complex subunit 3 (BRCC3) deubiquitinase downstream of all tested activation ...with NLRP3 priming. 42 NACHT ...
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Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome
... of NLRP3 and the apoptosis-related speckle-like protein containing a caspase recruitment domain (ASC) which controls the extent of inflam- masome activation and IL-1  ...the NLRP3 inflammasome is ...
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Inhibition of the NLRP3 inflammasome prevents ovarian aging
... of NLRP3 improved the survival and pregnancy rates and increased anti-Müllerian hormone levels and autophagy rates in ...of NLRP3 also reduced serum FSH and estradiol ...of NLRP3 using a direct ...
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The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection
... DISCUSSION Parasitic helminth infections are among the most common and debilitating causes of chronic disease in humans, infecting over a billion people worldwide. However, there are no vaccines that can protect humans ...
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Transcriptomic Analysis of Vulvovaginal Candidiasis Identifies a Role for the NLRP3 Inflammasome
... In conclusion, we have conducted an analysis of the host and fungal transcriptional response during murine vulvovaginal can- didiasis. Findings from this study have demonstrated that the physiological functions of innate ...
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Targeting the NLRP3 inflammasome in chronic inflammatory diseases: Current perspectives
... diseases. NLRP3 inflammasome The NLRP3 inflammasome is by far the most studied ...20 NLRP3 is expressed in the cytosol of monocytes, den- dritic cells, neutrophils, lymphocytes, ...
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Volcanic Ash Activates the NLRP3 Inflammasome in Murine and Human Macrophages
... The NLRP3 inflammasome as an ash- responsive element appears to be predominantly mediated by the crystalline silica phase (cristobalite), although other phases induced a low-level ...
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Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives
... diseases. NLRP3 inflammasome The NLRP3 inflammasome is by far the most studied ...20 NLRP3 is expressed in the cytosol of monocytes, den- dritic cells, neutrophils, lymphocytes, ...
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Increased expression of the NLRP3 inflammasome components in patients with Behçet’s disease
... The hypothesis of an environmental trigger in BD patients with genetic susceptibilities has long been advo- cated [2]. These triggers range from infections to mo- lecular mimicry such as heat-shock proteins (HSP), which ...
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Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy
... that NLRP3 is expressed in skeletal muscle and show that ApN downregulates NLRP3 via its anti- inflammatory mediator, ...the NLRP3 inflammasome in a murine model of DMD, we crossed mdx mice ...
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Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice
... Efficacious NLRP3 inflammasome inhibitors are cur- rently at an early stage of research and ...of NLRP3 that is essential for its activa- tion, and directly targets the NLRP3 ...
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The NLRP3 Inflammasome Detects Encephalomyocarditis Virus and Vesicular Stomatitis Virus Infection
... NLRP3 inflammasome is particularly notable because of its central role in diseases of ...the NLRP3 inflammasome in host defense against influenza ...the NLRP3 inflammasome in ...
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Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4
... as NLRP3 or NLRC4 and caspase-1 [28]. We investigated the role of the NLRP3 inflammasome in PLY-driven IL-1b secretion and found that the ability of PLY to promote IL-1b secretion was compromised in ...
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The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases
... the NLRP3 inflammasome by several different pathogenic particles and ...by inflammasome-mediated chemokines and cytokines during PM ...to NLRP3 inflammasome activation by noxious ...
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Targeting the NLRP3 inflammasome to Reduce Diet-induced Metabolic Abnormalities in Mice
... HD-fed NLRP3 –/– mice, and they were dramatically reduced in HD-mice treated with the NLRP3 inflammasome ...in NLRP3 inflammasome expression, resulting in inhibition of caspase-1 ...
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Diverse Activators of the NLRP3 Inflammasome Promote IL 1ß Secretion by Triggering Necrosis
... Given the precedent established by activation of the Apaf-1/ caspase-9 apoptosome, it is highly probable that the highly diverse triggers of the NLRP3 inflammasome also converge on some common event that is ...
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Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments
... ROS-‐related NLRP3 ligands have recently been proposed: TXNIP released from the redox system and oxidized mitochondrial ...impacts NLRP3 activation, potentially by removing ROS-‐producing dysfunctional ...
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NLRP3 Inflammasome and Pathobiology in AMD
... The NLRP3 inflammasome is activated in response to a variety of stimuli, including both infectious stimuli and sterile danger signals caused by cellular stress, such as a high concentration of extracellular ...
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Role of NLRP3 Inflammasome in Pathogenesis of Pulpal Disease
... the NLRP3 inflammasome pathway may play a key role in the progression of dental pulpitis and potentially serves as a functional biomarker for pulpal diagnosis in conjunction with standard clinical and ...
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