The NSs protein
The NSs Protein of Tomato spotted wilt virus Is Required for Persistent Infection and Transmission by Frankliniella occidentalis
... for NSs was more stringent in ...the NSs protein was not important for a relatively abundant accu- mulation in thrips larvae but became essential for maintaining efficient accumulation of virus in ...
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Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins
... (NS) protein, which is a major virulence factor for Rift Valley fever virus (RVFV), is encoded on the ...the NSs protein promotes the degradation of at least two host proteins, the TFIIH p62 and the ...
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Characterization of the non-structural (NSs) protein of tick-borne phleboviruses
... the NSs protein of a phlebovirus had an IFN antagonist role was the finding that the virulent RVFV strain ZH548 failed to induce IFN following infection and replicated efficiently in wild-type mice and mice ...
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Role of Bunyamwera orthobunyavirus NSs protein in infection of mosquito cells
... The NSs protein was required for efficient replication in both mosquito cells with a competent Dicer 2-RNAi system and in adult ...The NSs protein of Rift Valley fever phlebovirus (also in the ...
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Role of Bunyamwera orthobunyavirus NSs protein in infection of mosquito cells
... the NSs protein in mosquito cells, replication of wild-type virus and a recombinant NSs deletion mutant was compared in ...N protein production and virus yields at various times post ...of ...
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Toscana Virus NSs Protein Promotes Degradation of Double-Stranded RNA-Dependent Protein Kinase
... the NSs protein, and not another product of viral replication, is re- sponsible for mediating the downregulation of ...TOSV NSs protein alone was suffi- cient to downregulate PKR, we ...
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Interaction of Bunyamwera Orthobunyavirus NSs Protein with Mediator Protein MED8: a Mechanism for Inhibiting the Interferon Response
... The NSs protein of Bunyamwera virus (Bunyaviridae) is an antiapoptotic interferon antagonist involved in silencing host protein expression by interfering with mRNA ...of NSs with the MED8 ...
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Generation of Recombinant Oropouche Viruses Lacking the Nonstructural Protein NSm or NSs
... IMPORTANCE Oropouche virus (OROV) is a public health threat in Central and South America, where it causes periodic outbreaks of dengue- like illness. In Brazil, OROV is the second most frequent cause of arboviral febrile ...
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The N terminus of Bunyamwera orthobunyavirus NSs protein is essential for interferon antagonism
... The results presented in Figs 2 and 3 demonstrate the requirement of the first 21 aa of the NSs protein for its IFN-antagonist function. Although the interaction between NSs and Med8 is thought to be ...
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La Crosse Virus Nonstructural Protein NSs Counteracts the Effects of Short Interfering RNA
... the NSs protein of the closely related Bunyamwera virus (3, 38, 52, ...LACV NSs to suppress RNAi in mammalian cells adds to the growing body of evidence suggesting that RNAi also plays an antiviral ...
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NSs Protein of Rift Valley Fever Virus Induces the Specific Degradation of the Double-Stranded RNA-Dependent Protein Kinase
... the NSs protein induces the specific degradation of ...the NSs proteins of related but less-virulent bunyaviruses have no such activity, suggesting that the high pathogenicity of RVFV is promoted by ...
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Toscana Virus NSs Protein Inhibits the Induction of Type I Interferon by Interacting with RIG-I
... the NSs protein or by an indirect activation of cellular proteases, the effects of the MG-132 proteasome inhibitor were ...the NSs on RIG-I-mediated IFN-  activation was abrogated by MG- 132 in a ...
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Genetic Evidence for an Interferon-Antagonistic Function of Rift Valley Fever Virus Nonstructural Protein NSs
... Individual blood samples were collected at the indicated times after infection. Sera were pooled within each group, and ali- quots were assayed in parallel for infectious virus and IFN-␣/. Figure 5 shows that the ...
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The Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism
... nonstructural protein denominated ...an NSs protein. Data show that the NSs protein is expressed in the context of an ANDV ...the NSs initiation codon is mediated by ribosomal ...
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The Carboxy-Terminal Acidic Domain of Rift Valley Fever Virus NSs Protein Is Essential for the Formation of Filamentous Structures but Not for the Nuclear Localization of the Protein
... nonstructural protein NSs. Except for the fact that the NSs protein is phosphorylated and forms filamen- tous structures in the nuclei of infected cells ...expressed NSs in mammalian ...
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Tomato Spotted Wilt Virus NSs Protein Supports Infection and Systemic Movement of a Potyvirus and Is a Symptom Determinant
... The NSs protein is an RNA silencing suppressor in orthotospoviruses, such as the tomato spotted wilt virus ...by NSs and its role in virus infection and movement are poorly ...TSWV NSs and ...
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The transient nature of bunyamwera orthobunyavirus NSs protein expression : effects of increased stability of NSs protein on virus replication
... is NSs degraded during infection of mammalian cells? All the assays that test reported roles of NSs showed the non- degradable NSs4KR mutant protein to function at least as well as the wt NSs ...
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Generation of Mutant Uukuniemi Viruses Lacking the Nonstructural Protein NSs by Reverse Genetics Indicates that NSs Is a Weak Interferon Antagonist
... its NSs protein (38), as it is well known that BUNV NSs acts as a strong IFN antagonist (39, ...BUNV NSs, which is able to fully antagonize the IFN response in A549 cells, UUKV NSs acts ...
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Association of the nonstructural protein NSs of Uukuniemi virus with the 40S ribosomal subunit.
... translation of Uukuniemi virus-specific RNAs: identification of a nonstructural protein and a precursor to membrane glycopro- teins. Semliki Forest virus capsid protein associates with t[r] ...
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Generation of recombinant Oropouche viruses lacking the nonstructural protein NSm or NSs
... growth of rOROV, rOROVdelNSm and rOROVdelNSs were compared in A549 cells 400.. to their growth in IFN-incompetent A549/V cells.[r] ...
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