The pentose phosphate pathway
Metabolism VIII. Hexose Monophosphate Shunt (HMP Shunt) or Pentose Phosphate Pathway (PPP) Pentose Phosphate Pathway (PPP)
... the pentose phosphate ...the pathway, generally known as a committed step, is an essentially irreversible step, and is highly allosterically ...
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The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
... Fig. 2. The light-independent reactions of carbon fixation in the Calvin cycle share enzymes and reactions with the pentose phosphate pathway (PPP) and glycolysis. Abbreviations are defined in Table ...
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Emerging role of the pentose phosphate pathway in hepatocellular carcinoma
... Hepatocellular Carcinoma Marta Anna Kowalik*, Amedeo Columbano and Andrea Perra* Department of Biomedical Sciences, Unit of Oncology and Molecular Pathology, University of Cagliari, Cagliari, Italy In recent years, there ...
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The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy
... dinucleotide phosphate (NADPH) homeostasis in the survival of cancer cells under metabolic stress conditions, such as metabolic resource limitation and therapeu- tic ...the pentose phosphate ...
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Expression of Pentose Phosphate Pathway-Related Proteins in Breast Cancer
... the pentose phosphate pathway is an indispensable metabolic pathway in malignant tumors because of the demand for a high rate of nucleic acid synthesis during growth and the NADPH necessary ...
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The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration
... Recently, increasing preclinical and clinical evidence has revealed glucose metabolism disturbance in PD [2, 13– 15]. Interestingly, several recent studies have shown dys- regulation of the pentose ...
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Expression of Pentose Phosphate Pathway-Related Proteins in Breast Cancer
... Copyright © 2018 Junjeong Choi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
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Handling Uncertainty in Dynamic Models:The Pentose Phosphate Pathway in Trypanosoma brucei
... the pentose phosphate pathway (PPP) of ...This phosphate ‘‘leak’’ must be resolved for the model to be a reasonable representation of parasite ...
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Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway
... the pentose phosphate pathway (PPP), providing additional substrate for the enzyme NADPH oxidase and results in a pro-oxi- dant environment that exacerbates ...
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Systematic engineering of pentose phosphate pathway improves Escherichia coli succinate production
... Conclusions The pentose phosphate pathway of E. coli was systemati- cally engineered for improving reducing equivalent sup- ply and succinate production. Increased expression of each of Zwf, Pgl, ...
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Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes
... The pentose phosphate pathway (PPP) is a fundamental element of cell biochemistry since it is the major pathway for the recycling of NADP + to NADPH and for the production of ...
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Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration
... lower pentose-phosphate pathway (PPP); this led to oxidative stress and apoptotic neuronal death that was counteracted by overexpressing glucose-6-phosphate dehydrogenase, the rate-limiting ...
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Characterization and inhibition of NADPH-producing enzymes from the pentose phosphate pathway of Plasmodium parasites
... dinucleotide phosphate (NADPH) are employed to maintain the redox ...oxidative pentose phosphate pathway (PPP) is the main source of the critically important NADPH, generated by two enzymes: ...
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Original Article Exosomes mediated pentose phosphate pathway in ovarian cancer metastasis: a proteomics analysis
... the pentose phosphate pathway was a dominant mechanism in exosome mediated intracellular commu- ...regulated pentose phosphate pathway, were all marked in the same exosomal parts ...
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Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense
... the pentose phosphate pathway, which was uncoupled from nucleotide biosynthesis, albeit prevented oxidative stress in the form of oxidized ...the pentose phosphate pathway, G6PD ...
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ID1 promotes hepatocellular carcinoma proliferation and confers chemoresistance to oxaliplatin by activating pentose phosphate pathway
... ID1, an inhibitor of differentiation and DNA binding-1 and a member of the helix-loop-helix (HLH) transcrip- tion factor family [9], has been known to play a crucial role in mammary epithelial cells and cancer cells by ...
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ROLES OF BUFFERING CAPACITY AND PENTOSE PHOSPHATE PATHWAY ACTIVITY IN THE GAS GLAND OF THE GULF TOADFISH OPSANUS BETA
... the pentose phosphate pathway (also known as the hexose monophosphate shunt), respectively, contributes to gas exchange through pH and salting-out effects on the oxygen-carrying capacity of the ...
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Increased expression of the oxidative pentose phosphate pathway and gluconeogenesis in anaerobically growing xylose-utilizing Saccharomyces cerevisiae
... During xylose utilization, up-regulation of gluconeogene- sis and the oxidative pentose phosphate pathway coin- cided with anaerobiosis (Figure 4). On xylose, increased flux in the oxidative PPP is ...
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Differential Site-Based Expression of Pentose Phosphate Pathway-Related Proteins among Breast Cancer Metastases
... es Figure 3: Correlation between clinicopathologic factors and expression of pentose phosphate pathway-related proteins. patterns depending on the metastatic sites. Brain metastases showed higher ...
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Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma
... the pentose phosphate pathway (PPP) in human clear cell-renal cell carcinoma (ccRCC) and evaluate the role of these pathways in sustaining cell proliferation, maintenance of NADPH levels, and ...
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